H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

Product Name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
CAS No.: 199999-60-5
Chemical Name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
Synonyms: WP9QY;TNF-α Antagonist;WP9QY, W9, YCWSQYLCY;TNF-ALPHA ANTAGONIST;WP9QY, TNF-a Antagonist - 1 mg;TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST;H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH;161:PN:WO2010033207 SEQID:210 claimed protein;H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond);H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH,(DISULFIDE BOND BETWEEN CYS2 AND CYS 8
CBNumber: CB4146920
Molecular Formula: C58H71N11O15S2
Formula Weight: 1226.38
MOL File: 199999-60-5.mol

More

Less

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Property

Boiling point:: 1692.1±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 3.05±0.10(Predicted)
color: White to off-white
Water Solubility: water: 1mg/mL
5% acetic acid: 5mg/mL
Sequence: Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr (Disulfide bridge:Cys2-Cys8)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654255
Product name: TNF-α Antagonist
Purity: The TNF-α Antagonist controls the biological activity of TNF-α.
Packaging: 1MG
Price: $341
Updated: 2025/07/31

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 1mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 5mg
Price: $961
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PEP0005218
Product name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
Purity: 95.00%
Packaging: 5MG
Price: $495.77
Updated: 2021/12/16

More

Less

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Chemical Properties,Usage,Production

Uses

WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 5 μM as TNF-α antagonist

References

[1] Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14. DOI:10.1016/j.biomaterials.2009.05.083

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Suppliers

China 51 United States 6 Global 57

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

199999-60-5, H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OHRelated Search:

HUWENTOXIN IV GIP (1-39) PHRIXOTOXIN 3 Angiotensin II, 5-L-isoleucine-8-glycine- antibacterial protein ll-37 amide (human) PKA Inhibitor Fragment (6-22) amide LCKLSL 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- CALCIUM-LIKE PEPTIDE Dentonin DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS COG-1410 HNGF6A -Defensin-2 (human) (trifluoroacetate salt) L-Glutamine, L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-threonyl- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide C-PEPTIDE 2 (RAT) H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

WP9QY

TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST

TNF-ALPHA ANTAGONIST

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond)

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH,(Disulfide bond between Cys2 and Cys 8

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH,(DISULFIDE BOND BETWEEN CYS2 AND CYS 8

WP9QY, W9, YCWSQYLCY

TNF-α Antagonist

L-Tyrosine, L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-, cyclic (2→8)-disulfide

161:PN:WO2010033207 SEQID:210 claimed protein

WP9QY, TNF-a Antagonist - 1 mg

199999-60-5

C58H71N11O15S2