antibacterial protein ll-37 amide (human)

Product Name: antibacterial protein ll-37 amide (human)
CAS No.: 597562-32-8
Chemical Name: antibacterial protein ll-37 amide (human)
Synonyms: LL-37;LL-37 aMide;AntimicrobialPeptide，human;LL-37 amide (trifluoroacetate salt);Anti-LL37;Anti-CRAMP;Anti-HSD26;Anti-CAP18;Anti-FALL39;Anti-hCAP-18
CBNumber: CB8217046
Molecular Formula: C205H341N61O52
Formula Weight: 4492.27854
MOL File: 597562-32-8.mol

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antibacterial protein ll-37 amide (human) Property

storage temp.: -20°C
solubility: DMSO: Insoluble;Ethanol: 90 mg/mL (20.03 mM)
form: buffered aqueous solution
Water Solubility: Water: 90 mg/mL (20.03 mM)
Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu -Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
InChI: InChI=1S/C205H341N61O52/c1-20-114(16)162(262-180(298)128(66-40-46-86-211)236-177(295)135(74-78-155(274)275)244-171(289)125(63-37-43-83-208)242-193(311)149(107-268)259-175(293)126(64-38-44-84-209)235-172(290)129(67-47-87-226-201(216)217)241-186(304)142(98-119-55-29-24-30-56-119)253-188(306)144(100-121-59-33-26-34-60-121)254-190(308)146(102-158(280)281)234-154(273)104-231-168(286)138(94-109(6)7)249-167(285)122(212)93-108(4)5)195(313)232-105-153(272)233-123(61-35-41-81-206)169(287)243-136(75-79-156(276)277)178(296)252-141(97-118-53-27-23-28-54-118)185(303)239-124(62-36-42-82-207)170(288)237-131(69-49-89-228-203(220)221)182(300)264-164(116(18)22-3)198(316)260-160(112(12)13)196(314)247-134(73-77-151(213)270)176(294)238-132(70-50-90-229-204(222)223)181(299)263-163(115(17)21-2)197(315)246-127(65-39-45-85-210)173(291)257-147(103-159(282)283)191(309)255-143(99-120-57-31-25-32-58-120)187(305)250-139(95-110(8)9)184(302)240-130(68-48-88-227-202(218)219)174(292)256-145(101-152(214)271)189(307)251-140(96-111(10)11)192(310)261-161(113(14)15)200(318)266-92-52-72-150(266)194(312)245-133(71-51-91-230-205(224)225)183(301)265-165(117(19)269)199(317)248-137(76-80-157(278)279)179(297)258-148(106-267)166(215)284/h23-34,53-60,108-117,122-150,160-165,267-269H,20-22,35-52,61-107,206-212H2,1-19H3,(H2,213,270)(H2,214,271)(H2,215,284)(H,231,286)(H,232,313)(H,233,272)(H,234,273)(H,235,290)(H,236,295)(H,237,288)(H,238,294)(H,239,303)(H,240,302)(H,241,304)(H,242,311)(H,243,287)(H,244,289)(H,245,312)(H,246,315)(H,247,314)(H,248,317)(H,249,285)(H,250,305)(H,251,307)(H,252,296)(H,253,306)(H,254,308)(H,255,309)(H,256,292)(H,257,291)(H,258,297)(H,259,293)(H,260,316)(H,261,310)(H,262,298)(H,263,299)(H,264,300)(H,265,301)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,216,217,226)(H4,218,219,227)(H4,220,221,228)(H4,222,223,229)(H4,224,225,230)/t114-,115-,116-,117+,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,160-,161-,162-,163-,164-,165-/m0/s1
InChIKey: JATXYCFPJFQHBQ-XAMSXPGMSA-N
SMILES: O=C([C@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C(N([H])[H])=O)N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])/C(=N/[H])/N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([C@]([H])(C([H])([H])C(=O)O[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C([C@]([H])([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])/C(=N/[H])/N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C(N([H])[H])=O)N([H])C([C@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])/C(=N/[H])/N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C(=O)O[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C(C([H])([H])N([H])C([C@]([H])([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C(=O)O[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C([C@]([H])(C([H])([H])O[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])/C(=N/[H])/N([H])[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([C@]([H])(C([H])([H])C(=O)O[H])N([H])C(C([H])([H])N([H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[H])=O)C([H])([H])O[H])=O)C([H])([H])C([H])([H])C(=O)O[H])=O)[C@@]([H])(C([H])([H])[H])O[H])=O)C([H])([H])C([H])([H])C([H])([H])N([H])/C(=N/[H])/N([H])[H])=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1400041
Product name: Anti-CAMP antibody produced in mouse
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 50μg
Price: $555
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA029874
Product name: Anti-CAMP antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 25μL
Price: $294
Updated: 2024/03/01

Sigma-Aldrich

Product number: PRS4429
Product name: Anti-Cathelicidin antibody produced in rabbit
Purity: affinity isolated antibody, buffered aqueous solution
Packaging: 100μg
Price: $524
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA029874
Product name: Anti-CAMP antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100μL
Price: $547
Updated: 2024/03/01

Cayman Chemical

Product number: 24764
Product name: LL-37 amide (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $517
Updated: 2024/03/01

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antibacterial protein ll-37 amide (human) Chemical Properties,Usage,Production

Description

LL-37, also known as hCAP18, belongs to the cathelicidins family of antimicrobial peptides that possess strong antimicrobial activity across multiple species. In humans, this is the only cathelicidin present, and it is produced in epithelial cells through the proteolytic cleavage of the hCAP-18 protein. In addition to its antimicrobial properties, LL-37 also plays a crucial role in regulating the immune system. It can inhibit inflammatory responses by suppressing the activation of TLR2 and TLR4, which recognize different components of bacterial cell walls.

Chemical Properties

LL-37, a human antimicrobial peptide, is a white to off-white solid. This 37-residue peptide of cathelicidin origin is amphipathic and exhibits a broad spectrum of antimicrobial activity.

Uses

LL-37 is a human antimicrobial peptide of the cathelicidin family and corresponds to the 134-170 segment of human cationic antimicrobial protein 18 (hCAP18). It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is significantly resistant to proteolytic degradation in solution.

Origin

LL-37 has been extensively studied since its discovery in 1995. This substance is a host defense peptide released by hCAP18 which is the only human cathelicidin.

Biological Functions

LL-37 has moderate antimicrobial activities against numerous Gram-negative and Gram-positive bacteria, including pathogens from the Pseudomonas, Escherichia, Staphylococcus, and Enterococcus genera. LL-37 is able to kill bacteria through direct antibacterial activities, as well as through immunomodulation. Like other AMPs, the primary mechanism of action is membrane disruption. The net positive charge of +6 allows for LL-37 to bind to the negatively charged membrane of bacteria. Upon binding, the introduction of transmembrane pores causes a disruption of cell integrity that leads to cell lysis and death. In addition, LL-37 is able to permeate the cell membrane in order to interact with intracellular targets, such as acyl carrier proteins. LL-37 has additional immunomodulatory properties, including both pro-inflammatory and anti-inflammatory responses, that are important for the indirect killing of bacteria For example, LL-37 is capable of inducing cell migration, proliferation and differentiation[5].

Biological Activity

The human cathelicidin HDP, LL-37, an amphipathic α-helical peptide, had a quite medium-sensitive antimicrobial activity and, unusually, the capacity to adopt this structure also in aqueous solutions at physiological salt concentrations. Most other helical AMPs only do so in the presence of biological membranes. It also had a significant capacity as a chemotactic agent for different types of immune cells, could stimulate release of pro-inflammatory chemokines and cytokines, could repress the effects of pathogen associated molecular patterns (PAMPs) such as LPS and LTA and could stimulate propagation of some cells involved in healing processes— it was a truly pleiotropic host defence peptide[6].

References

[1] Singh et al., (2014) LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH. J. Biol. Chem. 289(40) 27614 PMID: 25092290.
[2] Tripathi et al., (2014) LL-37 modulates human neutrophil responses to influenza A virus. J. Leukoc. Biol. 96(5) 931 PMID: 25082153.
[3] Roth et al., (2020). LL-37 fights SARS-CoV-2: The Vitamin D-Inducible Peptide LL-37 Inhibits Binding of SARS-CoV-2 Spike Protein to its Cellular Receptor Angiotensin Converting Enzyme 2 In Vitro. [4] Preprint. doi: 10.1101/2020.12.02.408153
[5] Ridyard K, et al. The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent. Antibiotics, 2021; 10: 650.
[6] Xhindoli D, et al. The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator. Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015; 1858: 546-566.

antibacterial protein ll-37 amide (human) Preparation Products And Raw materials

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China 114 United States 8 Global 122

Chengdu Jinglin Biotechnology Co., Ltd.

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Nanjing Peptide Biotech Ltd.

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Chengdu Youngshe Chemical Co., Ltd.

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View Lastest Price from antibacterial protein ll-37 amide (human) manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: LL-37 597562-32-8
Price: US $20.00-100.00/g
Min. Order: 10g
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-06-05

WUHAN FORTUNA CHEMICAL CO., LTD

Product: LL-37 597562-32-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 100G
Release date: 2021-06-10

Shandong Deshang Chemical Co., Ltd.

Product: antibacterial protein ll-37 amide (human) 597562-32-8
Price: US $30.00-25.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10 tons
Release date: 2024-07-11

597562-32-8, antibacterial protein ll-37 amide (human)Related Search:

Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ferric acetylacetonate COBALT(II) ACETYLACETONATE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) METHYL ISOCYANOACETATE Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE Benzyl isocyanide Cupric acetylacetonate N-BUTYLISOCYANIDE

LL-37

ANTIBACTERIAL PROTEIN LL-37 AMIDE (HUMAN)

H-LEU-LEU-GLY-ASP-PHE-PHE-ARG-LYS-SER-LYS-GLU-LYS-ILE-GLY-LYS-GLU-PHE-LYS-ARG-ILE-VAL-GLN-ARG-ILE-LYS-ASP-PHE-LEU-ARG-ASN-LEU-VAL-PRO-ARG-THR-GLU-SER-NH2

LL-37 Antibacterial Protein LL-37 aMide (huMan), LL37, CAMP

Antibacterial Protein LL-37 aMide (huMan), CAMP, LL37

LL-37 aMide

Anti-CAMP (66-80) antibody produced in rabbit

Anti-CAMP Cathelicidin anti-microbial peptide precursor

Anti-CRAMP

Anti-CAMP antibody produced in mouse

Anti-HSD26

Anti-Cathelicidin antibody produced in rabbit

Anti-Cationic antimicrobial protein

Anti-hCAP-18

Anti-CAMP (151-165) antibody produced in rabbit

Anti-CAMP antibody produced in rabbit

Anti-CAP18

Anti-cathelicidin antimicrobial peptide

Anti-FALL39

Anti-FALL-39

Anti-LL37

LL-37 amide (trifluoroacetate salt)

LL-37 Antibacterial

LL-37(human)597562-32-8

LL-37,Human,ELISA kit

AntimicrobialPeptide，human

LL37, Antibacterial Protein LL-37 amide (human), CAMP

597562-32-8