ChemicalBook > CAS DataBase List > 2-8-Angiotensin II, 2-glycine-5-L-isoleucine-

2-8-Angiotensin II, 2-glycine-5-L-isoleucine-

Product Name
2-8-Angiotensin II, 2-glycine-5-L-isoleucine-
CAS No.
25849-90-5
Chemical Name
2-8-Angiotensin II, 2-glycine-5-L-isoleucine-
Synonyms
TRV055;2-8-Angiotensin II;2-8-Angiotensin II, 2-glycine-5-L-isoleucine-
CBNumber
CB58379268
Molecular Formula
C42H57N9O9
Formula Weight
831.97
MOL File
25849-90-5.mol
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2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Property

Boiling point:
1273.8±65.0 °C(Predicted)
Density 
1.296±0.06 g/cm3(Predicted)
form 
Solid
pka
3.56±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Chemical Properties,Usage,Production

Uses

TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling[1].

IC 50

AT1 Receptor

References

[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005

2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Suppliers

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