ChemicalBook > CAS DataBase List > 5-Methylnicotinic acid

5-Methylnicotinic acid

Product Name
5-Methylnicotinic acid
CAS No.
3222-49-9
Chemical Name
5-Methylnicotinic acid
Synonyms
RARECHEM AL BO 2392;Methomyl Impurity 3;5-Methylnicotic acid;5-METHYLNICOTINIC ACID;5-Methylnicohinic acid;5-Methylnicotinicacid,97%;Nicotinic Acid Impurity 28;5-Methylnicotinic acid 98%;Nicotine Related Compound 4;5-Methylnicotinic acid, 95+%
CBNumber
CB5714690
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
3222-49-9.mol
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5-Methylnicotinic acid Property

Melting point:
210-212°C
Boiling point:
303.9±22.0 °C(Predicted)
Density 
1.230±0.06 g/cm3(Predicted)
vapor pressure 
0.328Pa at 25℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Sparingly soluble (0.083 g/L at 25°C).
pka
2.27±0.10(Predicted)
form 
Solid:particulate/powder
Appearance
White to off-white Solid
BRN 
112288
InChI
InChI=1S/C7H7NO2/c1-5-2-6(7(9)10)4-8-3-5/h2-4H,1H3,(H,9,10)
InChIKey
DJDHHXDFKSLEQY-UHFFFAOYSA-N
SMILES
C1=NC=C(C)C=C1C(O)=O
LogP
1.23
CAS DataBase Reference
3222-49-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681237
Product name
5-Methylpyridine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$77.5
Updated
2023/06/20
TRC
Product number
M218850
Product name
5-MethylnicotinicAcid
Packaging
100mg
Price
$75
Updated
2021/12/16
Usbiological
Product number
281572
Product name
5-Methylnicotinic acid
Packaging
10g
Price
$322
Updated
2021/12/16
Oakwood
Product number
024697
Product name
5-Methylnicotinicacid
Purity
97%
Packaging
1g
Price
$9
Updated
2021/12/16
Oakwood
Product number
024697
Product name
5-Methylnicotinicacid
Purity
97%
Packaging
5g
Price
$10
Updated
2021/12/16
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5-Methylnicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

5-Methylnicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis

5-Methylnicotinic acid can be prepared by a one-step reaction under the condition of aqueous solvent, using 3,5-dimethylpyridine as the starting material and potassium permanganate as the oxidising agent, and reacted under mild conditions. The specific preparation method is as follows:
A, to 1200L running water is added in 2000L enamel reaction stills, then squeeze into 3,5- lutidines 120kg, stir, Between 25-35°C of temperature control, and 300kg potassium permanganate is added with 4.5h, be then incubated 30°C of reaction 16h；
B, filter core filter by-product manganese dioxide, and filtrate adjusts pH0.5 with concentrated hydrochloric acid；
C, centrifugation filter by-product 3, and 5- pyridinedicarboxylic acids, filtrate continuation adjusts PH3.0, crude product is collected by centrifugation with concentrated hydrochloric acid；
D, drying, crude product 1200L ethanol are heated to 80°C of dissolvings, heat filtering, and filtrate is cooled to 0-5°C of stirring 2h, from The heart, in drying 8.5h at 65°C, you can.The purity of final product is 99.5%.

References

[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: EP1193265, 2002, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2697 - 2703
[4] Journal of Chemical Research, Miniprint, 1987, # 9, p. 2360 - 2384

5-Methylnicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Methylnicotinic acid Suppliers

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View Lastest Price from 5-Methylnicotinic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Methylnicotinic acid 3222-49-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-06
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Methylnicotinic acid 3222-49-9
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
Henan Aochuang Chemical Co.,Ltd.
Product
5-Methylnicotinic acid 3222-49-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19

3222-49-9, 5-Methylnicotinic acidRelated Search:

EPA Folic acid Xanthinol nicotinate Isonicotinic acid Citric acid Ascoric Acid Diethyl pyridine-3,5-dicarboxylate DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE 5-ETHYLPYRIDINE-2,3-DICARBOXYLIC ACID Imazameth DIMETHYL 4-(4-METHOXYPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE 3,5-PYRIDINEDICARBOXYLIC ACID 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID CARBOXYLIC ACID 5-Methylnicotinic acid METHYL 2-ETHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE ETHYL 5-CYANO-6-(METHYLSULFANYL)-2-PHENYLNICOTINATE ETHYL 2-[2-(3,5-DICHLOROANILINO)VINYL]-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE

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