ChemicalBook > CAS DataBase List > Manidipine hydrochloride

Manidipine hydrochloride

Product Name
Manidipine hydrochloride
CAS No.
89226-75-5
Chemical Name
Manidipine hydrochloride
Synonyms
Calslot;CV 4093;CV-4093(2HCl);Manidipine DiHCl;cv-4093dihydrochlorde;Manidipine DihydrochL;Hydrochloric Manidipine;franidipinehydrochloride;MANIDIPINE HYDROCHLORIDE;Manidipine Dihydrochlorid
CBNumber
CB5715288
Molecular Formula
C35H40Cl2N4O6
Formula Weight
683.62
MOL File
89226-75-5.mol
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Manidipine hydrochloride Property

Melting point:
157-163°; mp 174-180°; mp 167-170°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
color 
White
Water Solubility 
Soluble in DMSO. Slightly soluble in water and ethanol /n
Merck 
14,5743
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
UFIXGLLGFBWKAV-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OCCN2CCN(C(C3=CC=CC=C3)C3=CC=CC=C3)CC2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl
CAS DataBase Reference
89226-75-5(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1/PG III
RTECS 
US7975300
HS Code 
2933.59.8000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2425
Product name
Manidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$53.28
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2425
Product name
Manidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$359
Updated
2024/03/01
TCI Chemical
Product number
M2225
Product name
Manidipine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$168
Updated
2024/03/01
TCI Chemical
Product number
M2225
Product name
Manidipine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$577
Updated
2023/06/20
Alfa Aesar
Product number
J60496
Product name
Manidipine dihydrochloride
Packaging
25mg
Price
$99.65
Updated
2024/03/01
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Manidipine hydrochloride Chemical Properties,Usage,Production

Description

Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4

Uses

aldosterone antagonist

Uses

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

Definition

ChEBI: Manidipine dihydrochloride is a diarylmethane.

References

Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130

Manidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Manidipine
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View Lastest Price from Manidipine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Manidipine hydrochloride 89226-75-5
Price
US $1.00/g
Min. Order
50g
Purity
98.0% ~ 101.5%,USP42
Supply Ability
5kg/month
Release date
2021-06-10
Xuchang Hengsheng Pharmaceutical Co., Ltd
Product
Manidipine Hydrochloride 89226-75-5
Price
US $0.00/Kg
Min. Order
1Kg
Purity
≥99.0%
Supply Ability
10 Tons
Release date
2024-08-07
Weijer International Trade (Hebei) Co., Ltd
Product
Manidipine hydrochloride 89226-75-5
Price
US $450.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
50000kg/Month
Release date
2023-03-17

89226-75-5, Manidipine hydrochlorideRelated Search:

Dimethyl sulfoxide Dimethyl ether N,N-Dimethylformamide N-Aminoethylpiperazine Levodropropizine Chlorodimethylphenylsilane ETHANE 2-Ethylhexyl ferulate Manidipine Dihydromyrcenol Benidipine hydrochloride Lercanidipine hydrochloride Dimethyl phthalate Dimethyl sulfide Nicardipine hydrochloride Dimethyl fumarate Methyl 2,2-dimethylphenylacetate Topotecan hydrochloride

  • 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride
  • cv-4093dihydrochlorde
  • franidipinehydrochloride
  • MANIDIPINE DIHYDROCHLORIDE
  • MANIDIPINE HYDROCHLORIDE
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
  • Calslot
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylMethyl)-1-piperazinyl]ethyl] 5-Methyl ester, hydrochloride(1:2)
  • CV-4093(2HCl)
  • Manidipine dihydrochloride (CV-4093)
  • CV 4093
  • Hydrochloric Manidipine
  • Manidipine DiHCl
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
  • Manidipine dihydrochloride, >=99%
  • Manidipine Dihydrochlorid
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyr
  • 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride
  • Manidipine Hydrochloride RS
  • ManidipineDihydrochloride&gt
  • Manidipine DihydrochL
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride
  • 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbo
  • Manidipine hydrochloride USP/EP/BP
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
  • 3-[2-(4-Benzhydryl-1-piperazinyl)ethyl] 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride
  • Manidipine Dihydrochloride, ≥ 98.0%
  • Manidipine dihydrochloride, 10 mM in DMSO
  • 89226-75-5
  • 82926-75-5
  • C35H38N4O6HCl
  • C35H40Cl2N4O6
  • C35H38N4O62HCl
  • Antihypertensive
  • API