ChemicalBook > CAS DataBase List > Manidipine hydrochloride

Manidipine hydrochloride

Product Name: Manidipine hydrochloride
CAS No.: 89226-75-5
Chemical Name: Manidipine hydrochloride
Synonyms: Calslot;CV 4093;CV-4093(2HCl);Manidipine DiHCl;cv-4093dihydrochlorde;Manidipine DihydrochL;Hydrochloric Manidipine;franidipinehydrochloride;MANIDIPINE HYDROCHLORIDE;Manidipine Dihydrochlorid
CBNumber: CB5715288
Molecular Formula: C35H40Cl2N4O6
Formula Weight: 683.62
MOL File: 89226-75-5.mol

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Manidipine hydrochloride Property

Melting point:: 157-163°; mp 174-180°; mp 167-170°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: White
Water Solubility: Soluble in DMSO. Slightly soluble in water and ethanol /n
Merck: 14,5743
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: UFIXGLLGFBWKAV-UHFFFAOYSA-N
SMILES: C1(C)NC(C)=C(C(OCCN2CCN(C(C3=CC=CC=C3)C3=CC=CC=C3)CC2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl
CAS DataBase Reference: 89226-75-5(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1/PG III
RTECS: US7975300
HS Code: 2933.59.8000
HazardClass: 6.1
PackingGroup: III
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $86.73
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $369
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $53.28
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $359
Updated: 2024/03/01

TCI Chemical

Product number: M2225
Product name: Manidipine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $151
Updated: 2025/07/31

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Manidipine hydrochloride Chemical Properties,Usage,Production

Description

Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4

Uses

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

Uses

aldosterone antagonist

Definition

ChEBI: Manidipine dihydrochloride is a diarylmethane.

Synthesis

89226-50-6

89226-75-5

Synthesis of 3-(2-(4-phenylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate from 3-(2-(4-phenylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5- Dicarboxylate dihydrochloride was prepared in the following general procedure: manidipine base (2.25 kg) was dissolved in a solvent mixture of dichloromethane (6.75 L) and methanol (4.5 L) and cooled to 0-10°C. Concentrated hydrochloric acid (1.07 L) was slowly added dropwise under stirring, and after completion of the dropwise addition, the reaction was continued with stirring for 1 hour by keeping the temperature at 0-10 °C. Subsequently, methyl tert-butyl ether (13.5 L) was added to the reaction system and stirring was continued for 1 h. A large amount of solid was observed to precipitate. Filtration was carried out and the filter cake was washed with a small amount of methyl tert-butyl ether. The filter cake was mixed with dichloromethane (22 L), refluxed and pulped for 1 hour, then cooled to room temperature and filtered again. The filter cake was washed with a small amount of methyl tert-butyl ether and finally dried at 40-50 °C in a blast to give a yellow solid product (2.05 kg). The yield of this step was 81.8% and the purity of the product was 99.8869% (see Figure 2 for HPLC analysis).

in vivo

Manidipine dihydrochloride (10 mg/kg, i.p., b.i.d. at day 4, day 5) prolongs survival in SFTSV-infected mice^[4].
Manidipine dihydrochloride (25 mg/kg, i.p., b.i.d. for 2 d, then daily for 19 d) protects mice from JEV infection^[5].
Manidipine dihydrochloride (3 mg/kg, i.g., once per day, 7 d) prevents isoproterenol-induced left ventricular hypertrophy in rats^[7].

Animal Model:	IFNAR^-/- mice^[4]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p. ), b.i.d. at day 4, day 5
Result:	Exhibited a modest, but statistically significant increase in the survival rate of lethal animal model with SFTSV infection, significantly reduced viral titers in the spleen and kidney.

Animal Model:	Adult female BALB/c mice (age, 4 weeks) ^[5]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection (i.p. ), b.i.d. for 2 days, then daily for 19 days
Result:	Reduced the mortality rate from 73% to 20%, significantly reduced the viral load in infected mice while remarkably alleviated brain damage phenomena. Had little effect on peripheral JEV infection, which indicated that manidipine protected the mice against JEV-induced lethality by decreasing the viral load in the brain.

Animal Model:	8-week-old male Wistar rats^[7]
Dosage:	3 mg/kg
Administration:	Intragastric gavage (i.g.), once per day for 7 d
Result:	Prevented isoproterenol-induced left ventricular hypertrophy (2.26±0.02 g/kg; p<0.01) as isoproterenol increased left ventricular weight (2.40±0.04 g/kg; p<0.01). Inhibited expression of mRNA of ANP (0.9-fold of the control value; p<0.01), collagen types I (1.1-fold; p<0.01) and type III (1.6-fold; p<0.01), and fibronectin (1.1-fold; p<0.01).

IC 50

T-type calcium channel

References

[1] MITSURU KAKIHANA Akinobu N Masahiro SUNO. Antihypertensive Effect of CV-4093-2HCI, a New Calcium Antagonist, in Three Rat Models of Hypertension[J]. Japanese journal of pharmacology, 1988, 48 2: Pages 223-228. DOI:10.1254/jjp.48.223
[2] KATE MCKEAGE Lesley J S. Manidipine: a review of its use in the management of hypertension.[J]. Drugs, 2004, 64 17: 1923-1940. DOI:10.2165/00003495-200464170-00011
[3] MOHAMMAD M. GHAHREMANPOUR. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2[J]. ACS Medicinal Chemistry Letters, 2020, 11 12: 2526-2533. DOI:10.1021/acsmedchemlett.0c00521
[4] BEATRICE MERCORELLI . Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein[J]. Antiviral research, 2018, 150: Pages 130-136. DOI:10.1016/j.antiviral.2017.12.014

Manidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Manidipine

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View Lastest Price from Manidipine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Manidipine hydrochloride 89226-75-5
Price: US $1.00/g
Min. Order: 50g
Purity: 98.0% ~ 101.5%,USP42
Supply Ability: 5kg/month
Release date: 2021-06-10

Xuchang Hengsheng Pharmaceutical Co., Ltd

Product: Manidipine Hydrochloride 89226-75-5
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: ≥99.0%
Supply Ability: 10 Tons
Release date: 2024-08-07

Weijer International Trade (Hebei) Co., Ltd

Product: Manidipine hydrochloride 89226-75-5
Price: US $450.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 50000kg/Month
Release date: 2023-03-17

89226-75-5, Manidipine hydrochlorideRelated Search:

Dimethyl sulfoxide Dimethyl ether N,N-Dimethylformamide N-Aminoethylpiperazine Levodropropizine Chlorodimethylphenylsilane ETHANE 2-Ethylhexyl ferulate Manidipine Dihydromyrcenol Benidipine hydrochloride Lercanidipine hydrochloride Dimethyl phthalate Dimethyl sulfide Nicardipine hydrochloride Dimethyl fumarate Methyl 2,2-dimethylphenylacetate Topotecan hydrochloride

4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride

cv-4093dihydrochlorde

franidipinehydrochloride

MANIDIPINE DIHYDROCHLORIDE

MANIDIPINE HYDROCHLORIDE

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)

Calslot

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylMethyl)-1-piperazinyl]ethyl] 5-Methyl ester, hydrochloride(1:2)

CV-4093(2HCl)

Manidipine dihydrochloride (CV-4093)

CV 4093

Hydrochloric Manidipine

Manidipine DiHCl

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)

Manidipine dihydrochloride, >=99%

Manidipine Dihydrochlorid

3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyr

2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride

Manidipine Hydrochloride RS

ManidipineDihydrochloride&gt

Manidipine DihydrochL

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride

2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbo

Manidipine hydrochloride USP/EP/BP

3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride

3-[2-(4-Benzhydryl-1-piperazinyl)ethyl] 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride

Manidipine Dihydrochloride, ≥ 98.0%

Manidipine dihydrochloride, 10 mM in DMSO

89226-75-5

82926-75-5

C35H38N4O6HCl

C35H40Cl2N4O6

C35H38N4O62HCl

Antihypertensive

API