Manidipine hydrochloride

Product Name: Manidipine hydrochloride
CAS No.: 89226-75-5
Chemical Name: Manidipine hydrochloride
Synonyms: Calslot;CV 4093;CV-4093(2HCl);Manidipine DiHCl;cv-4093dihydrochlorde;Manidipine DihydrochL;Hydrochloric Manidipine;franidipinehydrochloride;MANIDIPINE HYDROCHLORIDE;Manidipine Dihydrochlorid
CBNumber: CB5715288
Molecular Formula: C35H40Cl2N4O6
Formula Weight: 683.62
MOL File: 89226-75-5.mol

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Manidipine hydrochloride Property

Melting point:: 157-163°; mp 174-180°; mp 167-170°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: White
Water Solubility: Soluble in DMSO. Slightly soluble in water and ethanol /n
Merck: 14,5743
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 89226-75-5(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1/PG III
RTECS: US7975300
HS Code: 2933.59.8000
HazardClass: 6.1
PackingGroup: III
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $53.28
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2425
Product name: Manidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $359
Updated: 2024/03/01

TCI Chemical

Product number: M2225
Product name: Manidipine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $168
Updated: 2024/03/01

TCI Chemical

Product number: M2225
Product name: Manidipine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $577
Updated: 2023/06/20

Alfa Aesar

Product number: J60496
Product name: Manidipine dihydrochloride
Packaging: 25mg
Price: $99.65
Updated: 2024/03/01

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Manidipine hydrochloride Chemical Properties,Usage,Production

Description

Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4

Uses

aldosterone antagonist

Uses

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

Definition

ChEBI: Manidipine dihydrochloride is a diarylmethane.

References

Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130

Manidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Manidipine

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Manidipine hydrochloride Suppliers

Americas 1 Canada 1 China 220 China Hong Kong 1 Europe 2 Germany 2 India 13 Italy 2 Japan 1 South Korea 1 United Kingdom 5 United States 28 Global 277

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View Lastest Price from Manidipine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Manidipine hydrochloride 89226-75-5
Price: US $1.00/g
Min. Order: 50g
Purity: 98.0% ~ 101.5%,USP42
Supply Ability: 5kg/month
Release date: 2021-06-10

Weijer International Trade (Hebei) Co., Ltd

Product: Manidipine hydrochloride 89226-75-5
Price: US $450.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 50000kg/Month
Release date: 2023-03-17

Dideu Industries Group Limited

Product: Manidipine hydrochloride 89226-75-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-06

89226-75-5, Manidipine hydrochlorideRelated Search:

Dimethyl sulfoxide Dimethyl ether N,N-Dimethylformamide N-Aminoethylpiperazine Levodropropizine Chlorodimethylphenylsilane ETHANE 2-Ethylhexyl ferulate Manidipine Dihydromyrcenol Benidipine hydrochloride Lercanidipine hydrochloride Dimethyl phthalate Dimethyl sulfide Nicardipine hydrochloride Dimethyl fumarate Methyl 2,2-dimethylphenylacetate Topotecan hydrochloride

4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride

cv-4093dihydrochlorde

franidipinehydrochloride

MANIDIPINE DIHYDROCHLORIDE

MANIDIPINE HYDROCHLORIDE

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)

Calslot

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylMethyl)-1-piperazinyl]ethyl] 5-Methyl ester, hydrochloride(1:2)

CV-4093(2HCl)

Manidipine dihydrochloride (CV-4093)

CV 4093

Hydrochloric Manidipine

Manidipine DiHCl

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)

Manidipine dihydrochloride, >=99%

Manidipine Dihydrochlorid

3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyr

2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride

Manidipine Hydrochloride RS

ManidipineDihydrochloride&gt

Manidipine DihydrochL

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride

2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbo

Manidipine hydrochloride USP/EP/BP

3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride

3-[2-(4-Benzhydryl-1-piperazinyl)ethyl] 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride

Manidipine Dihydrochloride, ≥ 98.0%

89226-75-5

82926-75-5

C35H38N4O6HCl

C35H40Cl2N4O6

C35H38N4O62HCl

Antihypertensive

API