ChemicalBook > CAS DataBase List > 4-Fluorobenzylamine

4-Fluorobenzylamine

Product Name
4-Fluorobenzylamine
CAS No.
140-75-0
Chemical Name
4-Fluorobenzylamine
Synonyms
(4-Fluorophenyl)methanamine;P-FLUOROBENZYLAMINE;Benzylamine, p-fluoro-;NSC 158269;AURORA KA-7685;P-flubenzylamine;AKOS BBS-00003618;RARECHEM AL BW 0026;4-FLUOROBENZYLAMINE;4-fluro benzylamine
CBNumber
CB5716902
Molecular Formula
C7H8FN
Formula Weight
125.14
MOL File
140-75-0.mol
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4-Fluorobenzylamine Property

Melting point:
183 °C
Boiling point:
183 °C (lit.)
Density 
1.095 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.512(lit.)
Flash point:
152 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
9.01±0.10(Predicted)
form 
Liquid
Specific Gravity
1.101.095
color 
Clear colorless to light yellow
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
636501
InChIKey
IIFVWLUQBAIPMJ-UHFFFAOYSA-N
CAS DataBase Reference
140-75-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzenemethanamine, 4-fluoro-(140-75-0)
EPA Substance Registry System
Benzenemethanamine, 4-fluoro- (140-75-0)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-20/21/22
Safety Statements 
26-27-36/37/39-45-36/39
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
F 
10-34
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29214980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
162493
Product name
4-Fluorobenzylamine
Purity
97%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
162493
Product name
4-Fluorobenzylamine
Purity
97%
Packaging
25g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
F0252
Product name
4-Fluorobenzylamine
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
F0252
Product name
4-Fluorobenzylamine
Purity
>98.0%(GC)
Packaging
25g
Price
$56
Updated
2024/03/01
Alfa Aesar
Product number
A15486
Product name
4-Fluorobenzylamine, 98+%
Packaging
10g
Price
$31.65
Updated
2024/03/01
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4-Fluorobenzylamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.

General Description

[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.

Synthesis

In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.

4-Fluorobenzylamine Preparation Products And Raw materials

Raw materials

Phthalimide 4-fluorobenzene

Preparation Products

Flupirtine 4-FLUOROBENZYL ISOCYANATE
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4-Fluorobenzylamine Suppliers

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View Lastest Price from 4-Fluorobenzylamine manufacturers

Hebei Mojin Biotechnology Co.,Ltd
Product
4-Fluorobenzylamine 140-75-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-09
Anhui Dexinjia Biopharm Co., Ltd
Product
4-Fluorobenzylamine 140-75-0
Price
US $10.00-150.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
2 ton per month
Release date
2023-04-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluorobenzylamine 140-75-0
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-16

140-75-0, 4-FluorobenzylamineRelated Search:

4-Fluorobenzamide Trimethoprim Methylamine hydrochloride Meglumine Ethyl nicotinate Phenoxybenzamine hydrochloride Trimethylamine N-Methylbenzylamine 4-Fluorobenzoic acid Dibenzylamine Benzylamine 2,4-Difluorobenzylamine 4-Fluorothiophenol 4-Fluoromandelic acid Methyl 4-fluorobenzoate Ethyl 4-fluorobenzoate 4-Fluorobenzonitrile 4-Fluorobenzaldehyde

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