AM 630
- Product Name
- AM 630
- CAS No.
- 164178-33-0
- Chemical Name
- AM 630
- Synonyms
- AM 630;CS-1545;AM630;AM 630;SC-200365(AM-630);6-Iodopravadoline;AM630;AM 630;AM-630;Iodopravadoline (AM630);1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole;(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone;6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE
- CBNumber
- CB5731721
- Molecular Formula
- C23H25IN2O3
- Formula Weight
- 504.36
- MOL File
- 164178-33-0.mol
AM 630 Property
- Boiling point:
- 605.9±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >5mg/mL
- pka
- 6.98±0.10(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0327
- Product name
- AM630
- Purity
- ≥90% (HPLC)
- Packaging
- 5mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- SML0327
- Product name
- AM630
- Purity
- ≥90% (HPLC)
- Packaging
- 25mg
- Price
- $631
- Updated
- 2024/03/01
- Product number
- 10006974
- Product name
- AM630
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 10006974
- Product name
- AM630
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 10006974
- Product name
- AM630
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $412
- Updated
- 2024/03/01
AM 630 Chemical Properties,Usage,Production
Uses
AM630 has been used:
- as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from?Trametes versicolor (TPSP).
- as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
- as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.
Uses
AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction.
Definition
ChEBI: [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole.
Biological Activity
CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.
Biochem/physiol Actions
AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).
storage
Desiccate at +4°C
References
1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788.
AM 630 Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from AM 630 manufacturers
- Product
- AM 630;6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE 164178-33-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31