AM 630

ChemicalBook > CAS DataBase List > AM 630

Product Name: AM 630
CAS No.: 164178-33-0
Chemical Name: AM 630
Synonyms: AM 630;CS-1545;AM630;AM 630;SC-200365(AM-630);6-Iodopravadoline;AM630;AM 630;AM-630;Iodopravadoline (AM630);1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole;(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone;6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE
CBNumber: CB5731721
Molecular Formula: C23H25IN2O3
Formula Weight: 504.36
MOL File: 164178-33-0.mol

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AM 630 Property

Boiling point:: 605.9±55.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >5mg/mL
pka: 6.98±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0327
Product name: AM630
Purity: ≥90% (HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0327
Product name: AM630
Purity: ≥90% (HPLC)
Packaging: 25mg
Price: $631
Updated: 2024/03/01

Cayman Chemical

Product number: 10006974
Product name: AM630
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10006974
Product name: AM630
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 10006974
Product name: AM630
Purity: ≥98%
Packaging: 50mg
Price: $412
Updated: 2024/03/01

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AM 630 Chemical Properties,Usage,Production

Uses

AM630 has been used:

as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from?Trametes versicolor (TPSP).
as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.

Uses

AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction.

Definition

ChEBI: [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole.

Biological Activity

CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.

Biochem/physiol Actions

AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).

storage

Desiccate at +4°C

References

1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788.

AM 630 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AM 630 manufacturers

Career Henan Chemical Co

Product: AM 630;6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE 164178-33-0
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

164178-33-0, AM 630Related Search:

AM 251 ACEA 2-AG BML-190 5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL MEAD ACID ETHANOLAMIDE R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE ACPA ARACHIDONAMIDE (4-METHOXY-PHENYL)-(2-METHYL-1H-INDOL-3-YL)-METHANONE Pravadoline 3-ANISOYL-INDOLE 1-(1-ETHYL-1H-INDOL-3-YL)ETHANONE 3-benzoylindole 6-IODOINDOLE AM 630 (4-HYDROXYPHENYL)(1H-INDOL-3-YL)METHANONE

AM 630

6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE

SC-200365(AM-630)

1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole

(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone

AM630;AM 630;AM-630

Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-

Iodopravadoline (AM630)

AM630;AM 630

CS-1545

6-Iodopravadoline

164178-33-0

C23H25IN2O3

Cannabinoid receptor