AG 99

Product Name: AG 99
CAS No.: 122520-85-8
Chemical Name: AG 99
Synonyms: AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
CBNumber: CB5738937
Molecular Formula: C10H8N2O3
Formula Weight: 204.18
MOL File: 122520-85-8.mol

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AG 99 Property

Melting point:: 247 °C
Boiling point:: 544.4±50.0 °C(Predicted)
Density: 1.482±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: Brown solid.
pka: 8.81±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010313
Product name: AG-99
Purity: ≥98%
Packaging: 5mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 10010313
Product name: AG-99
Purity: ≥98%
Packaging: 10mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 10010313
Product name: AG-99
Purity: ≥98%
Packaging: 25mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 10010313
Product name: AG-99
Purity: ≥98%
Packaging: 50mg
Price: $264
Updated: 2024/03/01

TRC

Product number: A427035
Product name: AG99
Packaging: 5mg
Price: $305
Updated: 2021/12/16

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AG 99 Chemical Properties,Usage,Production

Uses

Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

References

[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.

AG 99 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 99 Suppliers

China 63 Europe 2 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 15 USA 1 Global 88

VDM Biochemicals

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Aladdin Scientific

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MP Biomedicals, Inc.

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View Lastest Price from AG 99 manufacturers

Career Henan Chemical Co

Product: AG 99 122520-85-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

122520-85-8, AG 99Related Search:

TYRPHOSTIN AG 126 TYRPHOSTIN AG 835 AG 18 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 220127-57-1 AG 99 NS-398 AG 213

TYRPHOSTIN AG 99

TYRPHOSTIN B40

TYRPHOSTIN 46

TYRPHOSTIN A46

3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE

ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE

AG 99

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide

(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE

TYRPHOSTIN A46 99%

2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

(E)-AG 99

(E)-Tyrphostin 46

(E)-Tyrphostin AG 99

2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-

2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

AG 99 USP/EP/BP

(E)-AG 99 (AG99)

inhibit,Inhibitor,(E) AG 99,Epidermal growth factor receptor,HER1,ErbB-1,EGFR,(E)AG 99,(E)-AG 99

(E)-AG 99, 10 mM in DMSO

122520-85-8

ALCOHOL

Intracellular Signaling