2-METHYLACETANILIDE Property

Melting point:

109-112 °C

Boiling point:

296 °C

Density 

1.16

refractive index 

1.5279 (estimate)

Flash point:

296°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

It is slightly soluble in acetone, chloroform, toluene, benzene.

form 

Solid

pka

15.13±0.70(Predicted)

color 

Needles

Merck 

14,74

BRN 

2207054

CAS DataBase Reference

120-66-1(CAS DataBase Reference)

EPA Substance Registry System

o-Acetotoluidide (120-66-1)

Safety

Hazard Codes 

Xn

Risk Statements 

36/37/38-22

Safety Statements 

37/39-26-36-36/37

RTECS 

AN2900000

Hazard Note 

Harmful

TSCA 

Yes

HS Code 

29242990

Hazardous Substances Data

120-66-1(Hazardous Substances Data)

Toxicity

mma-sat 1 mg/plate NTPTB* JAN 82

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

2-METHYLACETANILIDE Chemical Properties,Usage,Production

Chemical Properties

WHITE TO OFF-WHITE CRYSTALLINE POWDER

Uses

Acetanilide is used as an inhibitor of peroxides and?stabilizer for cellulose ester varnishes.?It is used as an intermediate for the synthesis of?rubber accelerators, dyes and dye intermediate and camphor. It is used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates.

Uses

o-Methylacetanilide is a substituted acetanilide that is used as precursor for various pharmaceuticals including their intermediates.

Definition

ChEBI: 2`-Methylacetanilide is a member of toluenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Organic Syntheses, Coll. Vol. 5, p. 650, 1973

General Description

Colorless crystals. Insoluble in water.

Air & Water Reactions

Water insoluble.

Reactivity Profile

2-METHYLACETANILIDE is an amide. Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the toluidide from hot H2O (solubility 1g/210mL), EtOH or aqueous EtOH. UV: max 230 and 280nm (EtOH). [Beilstein 12 H 792, 12 I 376, 12 II 439, 12 III 1853, 12 IV 1755.]