ChemicalBook > CAS DataBase List > (S)-(-)-Trityl glycidyl ether

(S)-(-)-Trityl glycidyl ether

Product Name: (S)-(-)-Trityl glycidyl ether
CAS No.: 129940-50-7
Chemical Name: (S)-(-)-Trityl glycidyl ether
Synonyms: Trityl-(s)-glycidyl ether;(S)-TRITYL GLYCIDYL ETHER;(S)-GLYCIDYL TRITYL ETHER;(S)-GlycidylTritylEther>(S)-(-)-GLYCIDYL TRITYL ETHER;(S)-(-)-TRITYL GLYCIDYL ETHER;Triphenylmethyl glycidyl ether;(2S) 2 (TRITYLOXYMETHYL)OXIRANE;(S)-2-((trityloxy)methyl)oxirane;(S)-(-)-Glycidyl Trityl Esther
CBNumber: CB5747605
Molecular Formula: C22H20O2
Formula Weight: 316.39
MOL File: 129940-50-7.mol

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(S)-(-)-Trityl glycidyl ether Property

Melting point:: 99-102 °C (lit.)
alpha: -10.5 º (c=1 in chloroform)
Boiling point:: 438.8±40.0 °C(Predicted)
Density: 1.146±0.06 g/cm3(Predicted)
refractive index: -11 ° (C=1, CHCl3)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: almost transparency in hot Methanol
form: powder to crystal
color: White to Light yellow
optical activity: [α]20/D 10.5°, c = 1 in chloroform
InChI: InChI=1S/C22H20O2/c1-4-10-18(11-5-1)22(24-17-21-16-23-21,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,21H,16-17H2/t21-/m0/s1
InChIKey: XFSXUCMYFWZRAF-NRFANRHFSA-N
SMILES: O1C[C@H]1COC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference: 129940-50-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HS Code: 29109000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 456268
Product name: (S)-(?)-Glycidyl trityl ether
Purity: 98%
Packaging: 5g
Price: $175
Updated: 2025/07/31

TCI Chemical

Product number: G0285
Product name: (S)-Glycidyl Trityl Ether
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: G0285
Product name: (S)-Glycidyl Trityl Ether
Purity: >98.0%(GC)
Packaging: 25g
Price: $194
Updated: 2025/07/31

TRC

Product number: T887958
Product name: (S)-(-)-TritylGlycidylEther
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK463794
Product name: (S)-Glycidyl Trityl Ether
Purity: 98%
Packaging: 1g
Price: $26
Updated: 2021/12/16

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(S)-(-)-Trityl glycidyl ether Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(-)-Glycidyl trityl ether may be used to prepare N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acid analogs, which are potent prostaglandin D₂ (PGD₂) receptor antagonists. It may also be used as a starting material in the multi-step synthesis of (-)-actisonitrile.

Synthesis

76-83-5

57044-25-4

129940-50-7

The general procedure for the synthesis of triphenylmethyl-(S)-glycidyl ethers from triphenylchloromethane and (R)-oxirane-2-methanol is as follows: the preparation of triphenylmethyl-protected glycidyl alcohol derivative 401 was carried out with reference to the literature methodology (Schweizer et al., Synthesis 2007, 3807-3814; this literature is incorporated herein by reference). The procedure was as follows: under argon protection, (β)-glycidol (5.0 g, 61 mmol) was dissolved in CH2Cl2 (30 mL) and slowly added to a stirred solution of triamcinolone chloride (18.6 g, 66.8 mmol) and triethylamine (16.9 mL, 122 mmol) in CH2Cl2 (67 mL) via a syringe under ice-bath conditions. After the addition of glycidol was completed, DMAP (742 mg, 6.08 mmol) was added to the reaction mixture. Subsequently, the reaction system was gradually warmed up to room temperature. After the reaction was carried out for 14 hours, the reaction mixture was diluted with 300 mL of saturated NH4Cl aqueous solution. It was further diluted with water to about 1 L to dissolve the precipitated salt. The product was extracted from the quenched solution with Et2O (3×); the combined ether layers were washed with brine, dried over MgSO4, filtered through filter paper, and concentrated by rotary evaporation to give a white solid. The crude product was purified by recrystallization from boiling MeOH (200 mL), resulting in the target product 401 (14.1 g, 73% yield) as white crystals. The NMR analysis of the obtained product was in agreement with literature reports (Schweizer et al., Synthesis 2007, 3807-3814).

References

[1] Synthesis, 2007, # 24, p. 3807 - 3814
[2] Tetrahedron Letters, 2000, vol. 41, # 33, p. 6323 - 6326
[3] Journal of Organic Chemistry, 2003, vol. 68, # 8, p. 3026 - 3042
[4] Journal of Organic Chemistry, 2013, vol. 78, # 11, p. 5172 - 5183
[5] Patent: WO2010/53572, 2010, A2. Location in patent: Page/Page column 163

(S)-(-)-Trityl glycidyl ether Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from (S)-(-)-Trityl glycidyl ether manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (S)-(-)-Trityl glycidyl ether 129940-50-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 100kg/month
Release date: 2021-12-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(-)-Trityl glycidyl ether 129940-50-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(-)-Trityl glycidyl ether 129940-50-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

129940-50-7, (S)-(-)-Trityl glycidyl etherRelated Search:

Trityl candesartan Glycidyl acrylate (R)-(+)-Trityl glycidyl ether Trityl Irbesartan Trityl candesartan cilexetil Ethylene glycol diglycidyl ether Allyl glycidyl ether Ethylbenzene 1,2,3-PROPANETRIOL GLYCIDYL ETHER Triphenylmethyl Chloride Dimethyl ether DIGLYCIDYL ETHER 2-Butoxyethanol BISPHENOL A DIGLYCIDYL ETHER RESIN Glycidyl phenyl ether λ-Cyhalothrin Trifluoromethanesulfonyl chloride Sodium trifluoromethanesulfinate

Triphenylmethyl glycidyl ether

(S)-(-)-TRITYL GLYCIDYL ETHER

(S)-TRITYL GLYCIDYL ETHER

(S)-(-)-GLYCIDYL TRIPHENYLMETHYL ETHER

(S)-GLYCIDYL TRIPHENYLMETHYL ETHER

(S)-(-)-GLYCIDYL TRITYL ETHER

(S)-GLYCIDYL TRITYL ETHER

(S)-2,3-EPOXY-1-PROPYL TRIPHENYLMETHYL ETHER

(S)-2-(TRIPHENYLMETHOXYMETHYL)OXIRANE

Trityl-(s)-glycidyl ether

(S)-(-)-TRITYL GLYCIDYL ETHER, 98%, (98% EE)

(S)-2-((trityloxy)methyl)oxirane

(S)-(-)-Glycidyl Trityl Esther

(S)-(-)-Glycidyl trityl ether, 98%, ee 98%

(S)-Glycidyl Triphenylmethyl Ether (S)-2-(Triphenylmethoxymethyl)oxirane

(S)-(-)-Glycidil triphenylmethyl ether

(S)-(-)-Glycidyl trityl ether, ee: 98%

Oxirane,2-[(triphenylmethoxy)methyl]-, (2S)-

(S)-Glycidyl Trityl Ether CID-2

(2S) 2 (TRITYLOXYMETHYL)OXIRANE

(S)-(-)-Glycidyl trityl ether, 98%, ee: 98%

(S)-GlycidylTritylEther&gt

(S)-Glycidyl Trityl Ether,(2S)-2-(trityloxymethyl)oxirane,(S)-Glycidyl Triphenylmethyl Ether,(S)-(?)-Glycidyl trityl ether,(S)-2-

(2S)-2-(Tribenzyloxy)methyloxirane

(<i>S</i>)-(?)-Glycidyl trityl ether

129940-50-7

Organic Building Blocks

Epoxides

Asymmetric Synthesis

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Oxiranes

Simple 3-Membered Ring Compounds

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Oxiranes

Simple 3-Membered Ring Compounds

Synthetic Organic Chemistry

chiral

Heterocyclic Compounds

Chiral Building Blocks

Epoxides

Organic Building Blocks