ChemicalBook > CAS DataBase List > N-Ethylmaleimide

N-Ethylmaleimide

Product Name
N-Ethylmaleimide
CAS No.
128-53-0
Chemical Name
N-Ethylmaleimide
Synonyms
NEM;1-ETHYL-1H-PYRROLE-2,5-DIONE;N-Ethylmaleinimide;1H-Pyrrole-2,5-dione, 1-ethyl-;NEMI;NSC 7638;N-Ethylm;NEMI/NEM;usafb-121;USAF B-121
CBNumber
CB5748314
Molecular Formula
C6H7NO2
Formula Weight
125.13
MOL File
128-53-0.mol
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N-Ethylmaleimide Property

Melting point:
43-46 °C(lit.)
Boiling point:
210 °C(lit.)
Density 
1.2500 (rough estimate)
refractive index 
1.4430 (estimate)
Flash point:
73 °C
storage temp. 
2-8°C
solubility 
methanol: 1 M at 20 °C, clear, colorless
pka
-2.18±0.20(Predicted)
form 
Crystalline Powder
color 
White to off-white
Water Solubility 
1 g/L (20 ºC)
Sensitive 
Light Sensitive
Merck 
14,3822
BRN 
112448
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
InChIKey
HDFGOPSGAURCEO-UHFFFAOYSA-N
CAS DataBase Reference
128-53-0(CAS DataBase Reference)
NIST Chemistry Reference
1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0)
EPA Substance Registry System
N-Ethylmaleimide (128-53-0)
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Safety

Hazard Codes 
T+
Risk Statements 
21-28-34-43-20/21
Safety Statements 
26-28-36/37/39-45-28A
RIDADR 
UN 2928 6.1/PG 2
WGK Germany 
3
RTECS 
UX9625000
F 
19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29251900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
04260
Product name
N-Ethylmaleimide
Purity
purum p.a., ≥99.0% (HPLC)
Packaging
5G-F
Price
$90.2
Updated
2024/03/01
Sigma-Aldrich
Product number
04260
Product name
N-Ethylmaleimide
Purity
purum p.a., ≥99.0% (HPLC)
Packaging
25G-F
Price
$286
Updated
2024/03/01
Sigma-Aldrich
Product number
04259
Product name
N-Ethylmaleimide
Purity
BioUltra, ≥99.0% (HPLC)
Packaging
5g
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
04259
Product name
N-Ethylmaleimide
Purity
BioUltra, ≥99.0% (HPLC)
Packaging
25g
Price
$661
Updated
2024/03/01
Sigma-Aldrich
Product number
04260
Product name
N-Ethylmaleimide
Purity
purum p.a., ≥99.0% (HPLC)
Packaging
5G
Price
$86.7
Updated
2023/01/07
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N-Ethylmaleimide Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.

Uses

N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.

Uses

In cancer research (possible antimitotic activity.)

Definition

ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.

Hazard

Lachrymator when liquid, a strong irritant.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Safety Profile

Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.

N-Ethylmaleimide Preparation Products And Raw materials

Raw materials

Maleic anhydride Paraffin, liquid Ethylamine

Preparation Products

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View Lastest Price from N-Ethylmaleimide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Ethylmaleimide 128-53-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Ethylmaleimide 128-53-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
N-Ethylmaleimide 128-53-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-19

128-53-0, N-EthylmaleimideRelated Search:

O-Phthalimide Bismaleimide Succinimide Maleimide N-Benzylmaleimide N,N'-1,3-Phenylene bismaleimide N-Phenylmaleimide DIALIFOS N-Succinimidyl 3-maleimidopropionate 3-MALEIMIDOPROPIONIC ACID 4-MALEIMIDOBUTYRIC ACID 3-Maleimidopropionic acid GMBS N-PROPYLMALEIMIDE N-Succinimidyl 6-maleimidohexanoate N-Butylmaleimide 6-Maleimidocaproic acid 4-MALEIMIDO-TEMPO

  • usafb-121
  • 1-ETHYL-1H-PYRROLE-2,5-DIONE
  • NEM
  • N-ETHYLMALEIMIDE
  • 1-Ethyl-1H-pyrrole-2,5-dione~NEM
  • N-ETHYLMALEIMIDE SIGMAULTRA
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  • N-EthylmaleimideA.R.
  • N-Ethylmaleimide-D5
  • 1H-Pyrrole-2,5-dione, 1-ethyl-
  • 1-ETHYLPYRROLE-2,5-DIONE
  • N-Ethylmaleinimid
  • N-ETHYLMALEIMIDE extrapure
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  • N-Ethylmaleinimide
  • N-ETHYLMALEIMIDERESEARCH GRADE
  • NEMI
  • N-Ethylmaleimide, 98+%
  • N-EthylMaleiMide(NEMI)
  • N-EthylMaleiMide, 99+% 5GR
  • NSC 7638
  • N-Ethylmaleimide - CAS 128-53-0 - Calbiochem
  • 1-ethyl-1h-pyrrole-5-dione
  • 5-dione,1-ethyl-1H-Pyrrole-2
  • ethvlmaleimide
  • Ethylmaleimide
  • Maleic acid N-ethylimide
  • maleicacidn-ethylimide
  • Maleimide, N-ethyl-
  • n-ethvlmaleimide
  • n-ethyl-maleimid
  • USAF B-121
  • N-ETHYLMALEIMIDE BIOULTRA, >= 99.0%
  • N-ETHYLMALEIMIDE BIOXTRA
  • N-Ethylmaleimide≥ 99.5% (GC)
  • N-Ethylmaleimide, 99%, reagent grade
  • N-Ethylmaleimide&gt
  • N-Ethylm
  • N-Ethylmaleimide(NEMI),≥98%
  • N-Ethylmaleimide ISO 9001：2015 REACH
  • n-Ethylmaleimide, ≥99.0% (HPLC)
  • N-Ethylmaleimide ExiPlus, Multi-Compendial, 99%
  • N-ETHYL MALEIMIDE For Synthesis
  • N-ETHYLMALEMIDE
  • N-ETHYLMALEIMIDE NEM 1-Ethyl-1H-pyrrole-2,5-dione
  • NEMI/NEM
  • N-Ethyl Maleimide 99% (NEM) For Synthesis
  • 128-53-0
  • 204-892-4
  • C6D5H2NO2
  • N-Substituted Maleimides, Succinimides & Phthalimides
  • N-Substituted Maleimides
  • Life Science Chemical Reagents
  • N-Substituted Maleimides
  • N-Substituted Maleimides, Succinimides & Phthalimides
  • Amines
  • Heterocycles