2-Fluoro-4-iodo-5-picoline
- Product Name
- 2-Fluoro-4-iodo-5-picoline
- CAS No.
- 153034-94-7
- Chemical Name
- 2-Fluoro-4-iodo-5-picoline
- Synonyms
- 2-Fluoro-4-iodo-5-methylpyridine;6-Fluoro-4-iodo-b-picoline;6-Fluoro-4-iodo-3-picoline;2-FLUORO-4-IODO-5-PICOLINE;Pyridine, 2-fluoro-4-iodo-5-methyl-;2-Fluoro-4-iodo-5-methylpyridine,95%;2-Fluoro-4-iodo-5-methylpyridine, 98%;2-Fluoro-4-iodo-5-methylpyridine≥ 99% (GC);2-Fluoro-4-iodo-5-picoline ISO 9001：2015 REACH;2-FLUORO-4-IODO-5-PICOLINE (2-FLUORO-4-IODO-5-METHYLPYRIDINE)
- CBNumber
- CB5752355
- Molecular Formula
- C6H5FIN
- Formula Weight
- 237.01
- MOL File
- 153034-94-7.mol
2-Fluoro-4-iodo-5-picoline Property
- Melting point:
- 40-45℃
- Boiling point:
- <50 C
- Density
- 1.892±0.06 g/cm3(Predicted)
- Flash point:
- >110°C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- pka
- -1.53±0.18(Predicted)
- form
- Solid
- color
- Off-white
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H5FIN/c1-4-3-9-6(7)2-5(4)8/h2-3H,1H3
- InChIKey
- BVKQLNXPPQEELX-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(C)C(I)=C1
- CAS DataBase Reference
- 153034-94-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-22
- Safety Statements
- 26-36-36/39
- WGK Germany
- 3
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 731404
- Product name
- 2-Fluoro-4-iodo-5-methylpyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $31.1
- Updated
- 2023/01/07
- Product number
- F1035
- Product name
- 2-Fluoro-4-iodo-5-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- F1035
- Product name
- 2-Fluoro-4-iodo-5-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $139
- Updated
- 2025/07/31
- Product number
- F591978
- Product name
- 2-Fluoro-4-iodo-5-methylpyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F591978
- Product name
- 2-Fluoro-4-iodo-5-methylpyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
2-Fluoro-4-iodo-5-picoline Chemical Properties,Usage,Production
Chemical Properties
crystals
Synthesis
2369-19-9
153034-94-7
The general procedure for the synthesis of 2-fluoro-4-iodo-5-methylpyridine from 2-fluoro-5-methylpyridine was as follows: diisopropylamine (92 mL) was added to tetrahydrofuran (THF, 1.2 L) under nitrogen protection and the mixture was cooled to -18 °C. A hexane solution of 2.69 M n-butyllithium (224 mL) was slowly added dropwise to this solution. After the dropwise addition was completed, the temperature of the reaction system was raised to -5 °C within 20 min under stirring and subsequently cooled to -73 °C. At this temperature, a THF solution (240 mL) of 2-fluoro-5-methylpyridine (61 g) was slowly added dropwise and the reaction was stirred at -75 °C for 3.5 hours. Subsequently, a THF solution (24 mL) of iodine (139 g) was added dropwise to the reaction solution and stirring was continued at -75 °C for 1 hour and 55 minutes. After the reaction was completed, water (220 mL) was added at the same temperature and stirred for 5 minutes. After returning the reaction system to room temperature, water (1.2 L) was added. Next, an aqueous solution (300 mL) of sodium thiosulfate pentahydrate (136 g) was added and stirred for 10 minutes. The mixture was extracted with methyl tert-butyl ether (MTBE, 1.2 L) and the organic layer was washed with saturated brine (500 mL). The combined aqueous layers were then extracted with MTBE (1 L). All organic layers were combined and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. To the residue n-heptane was added, cooled and filtered to collect the precipitated solid. The solids were washed with n-heptane and the filtrate was cooled and filtered again to collect the precipitate. The process was repeated 5 times to finally obtain 2-fluoro-4-iodo-5-methylpyridine (109.69 g). The product was characterized by 1H-NMR (400 MHz, CDCl3) and ESI-MS to confirm the correct structure.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 18, p. 4603 - 4606
[2] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[3] Patent: US2016/46623, 2016, A1. Location in patent: Paragraph 0166-0168
2-Fluoro-4-iodo-5-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-iodo-5-picoline manufacturers
- Product
- 2-Fluoro-4-iodo-5-picoline 153034-94-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-Fluoro-4-iodo-5-picoline 153034-94-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
- Product
- 2-Fluoro-4-iodo-5-picoline 153034-94-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-19