1H-Imidazole-4-carboxylic acid
- Product Name
- 1H-Imidazole-4-carboxylic acid
- CAS No.
- 1072-84-0
- Chemical Name
- 1H-Imidazole-4-carboxylic acid
- Synonyms
- 4-IMIDAZOLECARBOXYLIC ACID;1H-Imidazole-2-propanoic acid;NSC32340;NSC 32340;1H-IMidazole-4;5-Imidazolic acid;4-carboxyimidazole;4-hydroxy imizodale;RARECHEM AL BE 0762;1H-Imidazol-4-carbonsure
- CBNumber
- CB5769195
- Molecular Formula
- C4H4N2O2
- Formula Weight
- 112.09
- MOL File
- 1072-84-0.mol
1H-Imidazole-4-carboxylic acid Property
- Melting point:
- 294-295 °C (lit.)
- Boiling point:
- 495.0±18.0 °C(Predicted)
- Density
- 1.524±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Aqueous Acid (sparingly)
- form
- Liquid
- pka
- 2.69±0.10(Predicted)
- color
- Clear colorless
- InChI
- InChI=1S/C4H4N2O2/c7-4(8)3-1-5-2-6-3/h1-2H,(H,5,6)(H,7,8)
- InChIKey
- NKWCGTOZTHZDHB-UHFFFAOYSA-N
- SMILES
- C1NC(C(O)=O)=CN=1
- CAS DataBase Reference
- 1072-84-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- NI4001000
- HazardClass
- IRRITANT
- HS Code
- 29332900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 425842
- Product name
- 4-Imidazolecarboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- 425842
- Product name
- 4-Imidazolecarboxylic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $193
- Updated
- 2025/07/31
- Product number
- I0607
- Product name
- 4-Imidazolecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- I0607
- Product name
- 4-Imidazolecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- I350230
- Product name
- Imidazole-4-carboxylicAcid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
1H-Imidazole-4-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Gray or tan powder
Uses
4-Imidazolecarboxylic acid (ICA) was used in the synthesis of triphenymethyl-protected 4-imidazole carboxylic acid (trityl-ImCOOH) which is employed to functionalize poly(propylene imine) dendrimers.
It may be used in the following studies:
- In the synthesis of lanthanide sulfate–carboxylates, [Ln(HIMC)(SO4)(H2O)] (Ln = Dy and Eu, HIMC = 4-imidazolecarboxylic acid) by in situ decarboxylation in the presence of Cu(II) ions.
- As an internal standard to obtain calibration curve by plotting the peak area ratios of histamine (HA) and several metabolites isolated from C3H/HeNCrj mice hair relative to ICA.
- In the synthesis of tetranuclear manganese carboxylate complexes possessing imidazole-based N/O chelating ligands.
General Description
4-Imidazolecarboxylic acid (1H-imidazole-4-carboxylic acid, H2imc) is an imidazole derivative that contains an imidazole group and a carboxylate group. It has been widely utilized to generate different types of coordination polymers. The anion of 4-imidazolecarboxylic acid has been reported to stabilize binuclear hydroxo complexes of trivalent lanthanides in the pH range 7-10.
Synthesis
23785-21-9
1072-84-0
1. ethyl imidazole-4-carboxylate was mixed with potassium hydroxide solution at a mass ratio of 1:2.2, and the reaction was carried out at 30 °C. 2. After the reaction was completed, sulfuric acid solution was added slowly to adjust the pH of the reaction mixture to 1. 3. The crude product was purified by recrystallization to obtain 1H-imidazole-4-carboxylic acid.
References
[1] Patent: CN105693619, 2016, A. Location in patent: Paragraph 0010; 0088; 0089
[2] Patent: CN105622518, 2016, A. Location in patent: Paragraph 0083; 0094; 0095; 0096; 0097
[3] Patent: CN105622515, 2016, A. Location in patent: Paragraph 0074; 0075
1H-Imidazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Imidazole-4-carboxylic acid Suppliers
- Tel
- --
- Fax
- --
- pavel.hradil@scalelab.cz
- Country
- Czech Republic
- ProdList
- 7
- Advantage
- 58
View Lastest Price from 1H-Imidazole-4-carboxylic acid manufacturers
- Product
- 1H-Imidazole-4-carboxylic acid 1072-84-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 1H-Imidazole-4-carboxylic acid 1072-84-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 1H-Imidazole-4-carboxylic acid 1072-84-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09