ChemicalBook > CAS DataBase List > 2-Thiouracil

2-Thiouracil

Product Name
2-Thiouracil
CAS No.
141-90-2
Chemical Name
2-Thiouracil
Synonyms
TU;2-thioxo-2,3-dihydropyriMidin-4(1H)-one;Thiouracil;2-TU;Nobilen;DERACIL;Thiouraci;tiouracyl;THIURACIL;NSC 19473
CBNumber
CB5769908
Molecular Formula
C4H4N2OS
Formula Weight
128.15
MOL File
141-90-2.mol
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2-Thiouracil Property

Melting point:
>300 °C (lit.)
Density 
1.368 (estimate)
refractive index 
1.7000 (estimate)
storage temp. 
Store below +30°C.
solubility 
7.9g/l
pka
pKa 7.46 (Uncertain)
form 
Fine Crystalline Powder
color 
White to cream
Water Solubility 
0.5 g/L
λmax
271nm(H2O)(lit.)
Merck 
14,9366
BRN 
112227
InChIKey
ZEMGGZBWXRYJHK-UHFFFAOYSA-N
CAS DataBase Reference
141-90-2(CAS DataBase Reference)
IARC
2B (Vol. Sup 7, 79) 2001
NIST Chemistry Reference
2-Thiouracil(141-90-2)
EPA Substance Registry System
Thiouracil (141-90-2)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
40-45-20/21/22
Safety Statements 
36/37-53-45
WGK Germany 
3
RTECS 
YR1575000
TSCA 
Yes
HS Code 
29335995
Hazardous Substances Data
141-90-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T7750
Product name
2-Thiouracil
Purity
≥99%
Packaging
25g
Price
$61.3
Updated
2024/03/01
Sigma-Aldrich
Product number
T7750
Product name
2-Thiouracil
Purity
≥99%
Packaging
1kg
Price
$483
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21120
Product name
2-Thiouracil
Purity
for synthesis
Packaging
100G
Price
$67.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21120
Product name
2-Thiouracil
Purity
for synthesis
Packaging
500G
Price
$300
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21120
Product name
2-Thiouracil
Purity
for synthesis
Packaging
1KG
Price
$530
Updated
2024/03/01
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2-Thiouracil Chemical Properties,Usage,Production

Chemical Properties

white to cream fine crystalline powder

Uses

Reagent used in the preparation of Antithyroid agents.

Uses

antiviral, thyroid depressant

Uses

2-Thiouracil has been used in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)

Definition

ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.

Biochem/physiol Actions

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag).

Safety Profile

Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES.

Purification Methods

Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]

2-Thiouracil Preparation Products And Raw materials

Raw materials

Sodium Methoxide Thiourea

Preparation Products

PYRIMIDIN-4-OL 4-CHLORO-N-METHYLPYRIMIDIN-2-AMINE N-(4-AMINOPYRIMIDIN-2-YL)-N-METHYLAMINE 5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE Pyrimidine, 4-bromo- (8CI,9CI) 4-THIOURACIL 4-Hydroxypyrimidine 4-Pyrimidinol BENZYL-(2-METHYLSULFANYL-PYRIMIDIN-4-YL)-AMINE 4-Chloro-2-(methylsulfonyl)pyrimidine 5-BROMO-4-CHLORO-2-METHANESULFONYL-PYRIMIDINE 2-Methylthio-4-pyrimidinol 4-Chloro-2-methylthiopyrimidine
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2-Thiouracil Suppliers

Belgium 2 Canada 4 China 390 Europe 3 France 2 Germany 11 India 30 Japan 5 Slovakia 1 South Korea 2 Switzerland 6 The Netherlands 1 United Kingdom 16 United States 63 Global 536
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View Lastest Price from 2-Thiouracil manufacturers

Hebei Dangtong Import and export Co LTD
Product
2-Thiouracil 141-90-2
Price
US $268.00-250.00/kilograms
Min. Order
1kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-27
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
2-Thiouracil 141-90-2
Price
US $20.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
200000kg
Release date
2024-04-25
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
2-Thiouracil 141-90-2
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-05-14

141-90-2, 2-ThiouracilRelated Search:

Pyrimidine 2-(2-Aminoethyl)isothiourea dihydrobromide 1-PHENYL-2-THIOUREA N-Aminothiourea CHLOROPHOSPHONAZO III Tizoxanide-d4 Tiotropium D3 iodide 5,6-DIMETHYL-2-THIOURACIL 5-ETHYL-2-THIOURACIL 6-AMINO-2-THIOURACIL,4-Amino-2-thiouracil Malathion 5,6-DIAMINO-2-THIOURACIL,4,5-DIAMINO-2-THIOURACIL 6-AMINO-2-THIOURACIL MONOHYDRATE,6-AMINO-2-THIOURACIL HYDRATE 5-METHYL-2-THIOURACIL 5-PROPYL-2-THIOURACIL 6-FORMYL-2-THIOURACIL,6-FORMYL-2-THIOURACIL H2O 6-BENZYL-2-THIOURACIL 6-N-PROPYL-2-THIOURACIL,6-PROPYL-2-THIOURACIL,4-PROPYL-2-THIOURACIL

  • 2-Thiouracil Vetec(TM) reagent grade, 99%
  • 2-ThiouraCll
  • 4-HYDROXY-2-MERCAPTOPYRIMIDINE
  • 4-HYDROXY-2-THIOPYRIMIDINE
  • 2-MERCAPTO-4-PYRIMIDONE
  • 2-MERCAPTO-4-HYDROXYPYRIMIDINE
  • 2-thio-uraci
  • 2-TU
  • 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-
  • 4(1H)-Pyrimidinone,2,3-dihydro-2-thioxo-
  • 4-hydroxy-2(1h)-pyrimidinethione
  • 4-Hydroxy-2-pyrimidinethiol
  • 4-Pyrimidinol, 2-mercapto-
  • 6-Hydroxy-2-mercaptopyrimidine
  • 6-Thiouracil
  • Antagothyroid
  • Antagothyroil
  • nci-c01490
  • Nobilen
  • Thiouraci
  • Thiouracil
  • tiouracyl
  • TU
  • NSC 290412
  • NSC 290413
  • NSC 290414
  • 2-Mercapto-4-hydroxypyrimidine 2-Mercapto-4-pyrimidone
  • 2-THIOURACIL
  • 2,3-dihydro-2-thioxo-4(1h)-pyrimidinone
  • DERACIL
  • 2,3-dihydro-2-thioxo-4(1h)-pyrimidinon
  • Thiourea pyriMidine
  • 2-Thiouracil, TU
  • 2-thioxo-2,3-dihydropyriMidin-4(1H)-one
  • 2-mercapto-4(1h)-pyrimidinone
  • 2-mercapto-4-pyrimidino
  • 2-Mercapto-4-pyrimidinol
  • 2-Mercaptopyrimid-4-one
  • 2-Sulfanyl-4-pyrimidinol
  • 2-Thio-1,3-pyrimidin-4-one
  • 2-thio-2,4-(1h,3h)-pyrimidinedione
  • 2-thio-4-oxo-1,3-pyrimidine
  • 2-thio-4-oxypyrimidine
  • 2-thio-6-oxypyrimidine
  • Uracil, 2-thio-
  • 4-HYDROXY-2-MERCAPTOPYRIMIDINE / 2-THIOURACIL
  • 2-THIO-URACYLE
  • THIURACIL
  • 2-THIOURACIL VETRANAL, 250 MG
  • 2-ThiouracilForSynthesis
  • 2-Thiouracil, 98+%
  • 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo- (9CI)
  • 2-HYDROXY-2-MERCAPTOPYRIMIDINE
  • 2-THIOURACIL extrapure
  • 2-Sulfanylidene-1H-pyrimidin-4-one
  • 2-Thiouracil ,99%
  • 2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one
  • 2-sulfanylidene-1,2,3,4-tetrahydropyriMidin-4-one