2-Thiouracil

Product Name: 2-Thiouracil
CAS No.: 141-90-2
Chemical Name: 2-Thiouracil
Synonyms: TU;2-thioxo-2,3-dihydropyriMidin-4(1H)-one;Thiouracil;2-TU;Nobilen;DERACIL;Thiouraci;tiouracyl;THIURACIL;NSC 19473
CBNumber: CB5769908
Molecular Formula: C4H4N2OS
Formula Weight: 128.15
MOL File: 141-90-2.mol

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2-Thiouracil Property

Melting point:: >300 °C (lit.)
Density: 1.368 (estimate)
refractive index: 1.7000 (estimate)
storage temp.: Store below +30°C.
solubility: 7.9g/l
pka: pKa 7.46 (Uncertain)
form: Fine Crystalline Powder
color: White to cream
Water Solubility: 0.5 g/L
λmax: 271nm(H2O)(lit.)
Merck: 14,9366
BRN: 112227
InChIKey: ZEMGGZBWXRYJHK-UHFFFAOYSA-N
CAS DataBase Reference: 141-90-2(CAS DataBase Reference)
IARC: 2B (Vol. Sup 7, 79) 2001
NIST Chemistry Reference: 2-Thiouracil(141-90-2)
EPA Substance Registry System: Thiouracil (141-90-2)

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Safety

Hazard Codes: Xn,T
Risk Statements: 40-45-20/21/22
Safety Statements: 36/37-53-45
WGK Germany: 3
RTECS: YR1575000
TSCA: Yes
HS Code: 29335995
Hazardous Substances Data: 141-90-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H351Suspected of causing cancer
Precautionary statements: P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T7750
Product name: 2-Thiouracil
Purity: ≥99%
Packaging: 25g
Price: $61.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: T7750
Product name: 2-Thiouracil
Purity: ≥99%
Packaging: 1kg
Price: $483
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.21120
Product name: 2-Thiouracil
Purity: for synthesis
Packaging: 100G
Price: $67.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.21120
Product name: 2-Thiouracil
Purity: for synthesis
Packaging: 500G
Price: $300
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.21120
Product name: 2-Thiouracil
Purity: for synthesis
Packaging: 1KG
Price: $530
Updated: 2024/03/01

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2-Thiouracil Chemical Properties,Usage,Production

Chemical Properties

white to cream fine crystalline powder

Uses

Reagent used in the preparation of Antithyroid agents.

Uses

antiviral, thyroid depressant

Uses

2-Thiouracil has been used in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)

Definition

ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.

Biochem/physiol Actions

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag).

Safety Profile

Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES.

Purification Methods

Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]

2-Thiouracil Preparation Products And Raw materials

Raw materials

Sodium Methoxide Thiourea

Preparation Products

PYRIMIDIN-4-OL 4-CHLORO-N-METHYLPYRIMIDIN-2-AMINE N-(4-AMINOPYRIMIDIN-2-YL)-N-METHYLAMINE 5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 4-Bromopyrimidine 4-THIOURACIL 4-Hydroxypyrimidine 4-Pyrimidinol BENZYL-(2-METHYLSULFANYL-PYRIMIDIN-4-YL)-AMINE 4-Chloro-2-(methylsulfonyl)pyrimidine 5-BROMO-4-CHLORO-2-METHANESULFONYL-PYRIMIDINE 2-Methylthio-4-pyrimidinol 4-Chloro-2-methylthiopyrimidine

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2-Thiouracil Suppliers

Belgium 2 Canada 4 China 409 Europe 3 France 2 Germany 11 India 30 Japan 5 Slovakia 1 South Korea 2 Switzerland 6 The Netherlands 1 United Kingdom 16 United States 64 Global 556

TCI Chemicals (India) Pvt. Ltd.

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View Lastest Price from 2-Thiouracil manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: 2-Thiouracil 141-90-2
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20Ton
Release date: 2024-11-13

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Thiouracil 141-90-2
Price: US $99.00-66.00/kg
Min. Order: 0.0010000000474974513kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Hebei Dangtong Import and export Co LTD

Product: 2-Thiouracil 141-90-2
Price: US $268.00-250.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-02-27

141-90-2, 2-ThiouracilRelated Search:

Pyrimidine 2-(2-Aminoethyl)isothiourea dihydrobromide 1-PHENYL-2-THIOUREA N-Aminothiourea CHLOROPHOSPHONAZO III Tizoxanide-d4 Tiotropium D3 iodide 5,6-DIMETHYL-2-THIOURACIL 5-ETHYL-2-THIOURACIL 6-AMINO-2-THIOURACIL,4-Amino-2-thiouracil Malathion 5,6-DIAMINO-2-THIOURACIL,4,5-DIAMINO-2-THIOURACIL 6-AMINO-2-THIOURACIL MONOHYDRATE,6-AMINO-2-THIOURACIL HYDRATE 5-METHYL-2-THIOURACIL 5-PROPYL-2-THIOURACIL 6-FORMYL-2-THIOURACIL,6-FORMYL-2-THIOURACIL H2O 6-BENZYL-2-THIOURACIL 6-N-PROPYL-2-THIOURACIL,6-PROPYL-2-THIOURACIL,4-PROPYL-2-THIOURACIL

2-Thiouracil Vetec(TM) reagent grade, 99%

2-ThiouraCll

4-HYDROXY-2-MERCAPTOPYRIMIDINE

4-HYDROXY-2-THIOPYRIMIDINE

2-MERCAPTO-4-PYRIMIDONE

2-MERCAPTO-4-HYDROXYPYRIMIDINE

2-thio-uraci

2-TU

4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-

4(1H)-Pyrimidinone,2,3-dihydro-2-thioxo-

4-hydroxy-2(1h)-pyrimidinethione

4-Hydroxy-2-pyrimidinethiol

4-Pyrimidinol, 2-mercapto-

6-Hydroxy-2-mercaptopyrimidine

6-Thiouracil

Antagothyroid

Antagothyroil

nci-c01490

Nobilen

Thiouraci

Thiouracil

tiouracyl

TU

NSC 290412

NSC 290413

NSC 290414

2-Mercapto-4-hydroxypyrimidine 2-Mercapto-4-pyrimidone

2-THIOURACIL

2,3-dihydro-2-thioxo-4(1h)-pyrimidinone

DERACIL

2,3-dihydro-2-thioxo-4(1h)-pyrimidinon

Thiourea pyriMidine

2-Thiouracil, TU

2-thioxo-2,3-dihydropyriMidin-4(1H)-one

2-mercapto-4(1h)-pyrimidinone

2-mercapto-4-pyrimidino

2-Mercapto-4-pyrimidinol

2-Mercaptopyrimid-4-one

2-Sulfanyl-4-pyrimidinol

2-Thio-1,3-pyrimidin-4-one

2-thio-2,4-(1h,3h)-pyrimidinedione

2-thio-4-oxo-1,3-pyrimidine

2-thio-4-oxypyrimidine

2-thio-6-oxypyrimidine

Uracil, 2-thio-

4-HYDROXY-2-MERCAPTOPYRIMIDINE / 2-THIOURACIL

2-THIO-URACYLE

THIURACIL

2-THIOURACIL VETRANAL, 250 MG

2-ThiouracilForSynthesis

2-Thiouracil, 98+%

4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo- (9CI)

2-HYDROXY-2-MERCAPTOPYRIMIDINE

2-THIOURACIL extrapure

2-Sulfanylidene-1H-pyrimidin-4-one

2-Thiouracil ,99%

2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one

2-sulfanylidene-1,2,3,4-tetrahydropyriMidin-4-one