ChemicalBook > CAS DataBase List > N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
- Product Name
- N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
- CAS No.
- 1715-30-6
- Chemical Name
- N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
- Synonyms
- QR-711;WIN-21904;Bisguadine;Sterwin 904;Compound-904;Bisguanidine;Alexidine Dihydrochloride extrapure, 96%;1,1'-Hexamethylenebis[5-(2-ethylhex-1-yl)]biguanide dihydrochloride;1,1'-Hexamethylenebis(5-(2-ethylhex-1-yl))biguanide dihydrochloride;N,N''-Bis(2-ethylhexyl)-3,12-diiMino-2,4,11,13-tetraazatetradecanediiMidaMide
- CBNumber
- CB5902570
- Molecular Formula
- C26H58Cl2N10
- Formula Weight
- 581.71172
- MOL File
- 1715-30-6.mol
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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Property
- Melting point:
- 220.6-223.4°C
- storage temp.
- -20°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to off-white
- Stability:
- Hygroscopic
- EPA Substance Registry System
- 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride (1715-30-6)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- A8986
- Product name
- Alexidine dihydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 10mg
- Price
- $84.1
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- A8986
- Product name
- Alexidine dihydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 50mg
- Price
- $340
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13876
- Product name
- Alexidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13876
- Product name
- Alexidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $63
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13876
- Product name
- Alexidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $100
- Updated
- 2024/03/01
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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Powder with Light Yellow Cast
Uses
Has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
Uses
Alexidine dihydrochloride has been used:
- as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms
- as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8+ T cells
- as a PTPMT1 inhibitor to study its antiviral effect on ?human cytomegalovirus?(HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells
Biological Activity
selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (ptpmt1) (ic50 = 1.08 μm in vitro). stimulates increased insulin secretion by β-cells in rat pancreatic islets. displays antitcancer properties in fadu cells.
Biochem/physiol Actions
Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.
storage
Desiccate at -20°C
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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