2-Methyl-1H-imidazole-4-carboxylic acid
- Product Name
- 2-Methyl-1H-imidazole-4-carboxylic acid
- CAS No.
- 1457-58-5
- Chemical Name
- 2-Methyl-1H-imidazole-4-carboxylic acid
- Synonyms
- 2-methyl-1H-imidazole-5-carboxylic acid;2-Methyl-4-carboxyiMidazole;2-Methyl-1H-imidazole-4-car;2-Methyl-1H-imidazol-4-carbonsure;2-MethyliMidazole-4-carboxylic acid;2-Methyl-4-iMidazolecarboxylic Acid;2-methyl-1H-imidazole-5-carboxylicaci;2-Methyl-1H-imidazol-5-carboxylic acid;2-Methyl-1H-imidazol-4-carboxylic acid;2-Methyl-1H-imidazole-4-carboxylic acid
- CBNumber
- CB5905773
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 1457-58-5.mol
2-Methyl-1H-imidazole-4-carboxylic acid Property
- Boiling point:
- 475.8±18.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.76±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H6N2O2/c1-3-6-2-4(7-3)5(8)9/h2H,1H3,(H,6,7)(H,8,9)
- InChIKey
- DTUIYOVMTFYCBZ-UHFFFAOYSA-N
- SMILES
- C1(C)NC(C(O)=O)=CN=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M313010
- Product name
- 2-Methyl-1H-imidazole-5-carboxylicAcid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CHM0149672
- Product name
- 2-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $852.55
- Updated
- 2021/12/16
- Product number
- CHM0149672
- Product name
- 2-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
- Product number
- W3181
- Product name
- 2-Methyl-1H-imidazole-4-carboxylicacid
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 134953
- Product name
- 2-Methyl-1H-imidazole-4-carboxylicacid
- Purity
- 95%+
- Packaging
- 5g
- Price
- $1462
- Updated
- 2021/12/16
2-Methyl-1H-imidazole-4-carboxylic acid Chemical Properties,Usage,Production
Uses
2-Methyl-1H-imidazole-4-carboxylic acid can be used as an intermediate for the preparation of heteroaryl oxadiazole derivative useful for the treatment of hyperproliferative and angiogenesis disorders.
Synthesis
35034-22-1
1457-58-5
General procedure for the synthesis of 2-methyl-1H-imidazole-5-carboxylic acid from 2-methyl-1H-imidazole-5-carboxaldehyde: To a solution of 2-methyl-1H-imidazole-5-carboxaldehyde (10 g, 91 mmol) in acetonitrile (ACN, 60 mL) was added sulfamic acid (11 g, 120 mmol) at 0 °C and the reaction solution was stirred for 5 min. Subsequently, 2-methyl-2-butene (13 mL, 120 mmol) was added. An aqueous solution of sodium chlorite (11 g, 120 mmol) was slowly added dropwise to the reaction mixture, and after completion of the dropwise addition, the reaction system was brought to room temperature and stirring was continued for 4 hours. After completion of the reaction, acetonitrile (MeCN) was removed by distillation under reduced pressure. The reaction was quenched with 1.5 N hydrochloric acid (HCl) and subsequently extracted with ethyl acetate (EtOAc, 250 mL x 3). The organic phases were combined, washed with brine (200 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 2-methyl-1H-imidazole-5-carboxylic acid (9.0 g, 71 mmol, 79% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.94 (brs, 1H), 9.61 (s, 1H), 7.88 (s, 1H), 1.91 (s, 3H).
References
[1] Patent: WO2014/144037, 2014, A1. Location in patent: Page/Page column 185
[2] Journal of the American Chemical Society, 2002, vol. 124, # 38, p. 11272 - 11273
2-Methyl-1H-imidazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-1H-imidazole-4-carboxylic acid manufacturers
- Product
- 2-Methyl-1H-imidazole-4-carboxylic acid 1457-58-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Methyl-1H-imidazole-4-carboxylic acid 1457-58-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-09