2-(6-Aminopurin-9-yl)ethanol
- Product Name
- 2-(6-Aminopurin-9-yl)ethanol
- CAS No.
- 707-99-3
- Chemical Name
- 2-(6-Aminopurin-9-yl)ethanol
- Synonyms
- Adefovir Impurity 5 CRS;6-AMINO-9H-PURIN-9-ETHANOL;9-(2-hydroxyethyl) adenine;Tenofovir Ethanol Impurity;9-(2-Hydroxyethyl)adenine>2-(6-AMINOPURIN-9-YL)ETHANOL;9H-Purine-9-ethanol, 6-amino-;2-(6-azanylpurin-9-yl)ethanol;Tenofovirdisoproxil Impurity 39;6-Amino-9-(2-hydroxyethyl)purine
- CBNumber
- CB5947254
- Molecular Formula
- C7H9N5O
- Formula Weight
- 179.18
- MOL File
- 707-99-3.mol
2-(6-Aminopurin-9-yl)ethanol Property
- Melting point:
- 240.0 to 244.0 °C
- Boiling point:
- 473.2±55.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
- pka
- 14.35±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 10g/L at 20℃
- λmax
- 261nm(H2O)(lit.)
- InChIKey
- VAQOTZQDXZDBJK-UHFFFAOYSA-N
Safety
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H1290
- Product name
- 9-(2-Hydroxyethyl)adenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- H1290
- Product name
- 9-(2-Hydroxyethyl)adenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $212
- Updated
- 2025/07/31
- Product number
- A628908
- Product name
- 2-(6-Aminopurin-9-yl)ethanol
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A628908
- Product name
- 2-(6-Aminopurin-9-yl)ethanol
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- NUC0001078
- Product name
- 9-(2-HYDROXYETHYL)ADENINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $834.74
- Updated
- 2021/12/16
2-(6-Aminopurin-9-yl)ethanol Chemical Properties,Usage,Production
Uses
2-(6-Aminopurin-9-yl)ethanol is a useful intermediate in the preparation of aryloxyalkyl derivatives of adenine with antiviral activity.
Synthesis
96-49-1
66224-66-6
707-99-3
Example 5 Preparation of 9-(2-hydroxyethyl)adenine (5) A mechanical stirrer, condenser tube, thermometer and heating jacket were assembled on a 12L three-necked round bottom flask. After the system was replaced by nitrogen, adenine (504 g), vinyl carbonate (343 g), N,N-dimethylformamide (DMF, 3.7 L) and sodium hydroxide (7.80 g) were added sequentially. Stirring was turned on and the mixture was heated to reflux (about 80 min to reach reflux, reactor internal temperature 145°C) and the reflux reaction was maintained for 2 hours. The heating jacket was removed and the yellow reaction solution was allowed to cool naturally to below 100°C. The mixture was then cooled to 5 °C in an ice bath and diluted with the addition of toluene (3.8 L). The temperature of the reaction system was kept below 10 °C and the stirring was continued for 2 hours and then filtered. The filter cake was washed sequentially with toluene (2 x 0.5 L) and pre-cooled ethanol (1.5 L), and finally dried under reduced pressure conditions (-30 inches Hg) at 50 °C for 14 h to constant weight. The resulting product 5 was characterized for purity and structure by HPLC and 1H-NMR (DMSO-d6).
References
[1] Patent: CN106699814, 2017, A. Location in patent: Paragraph 0020-0021
[2] Molecules, 2012, vol. 17, # 11, p. 13290 - 13306
[3] Patent: US2003/225277, 2003, A1. Location in patent: Page 10-11
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1767 - 1770
[5] Patent: CN104387421, 2016, B. Location in patent: Paragraph 0026-0028
2-(6-Aminopurin-9-yl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(6-Aminopurin-9-yl)ethanol manufacturers
- Product
- Tenofovir impurity 39 707-99-3
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-02-13
- Product
- 2-(6-Aminopurin-9-yl)ethanol 707-99-3
- Price
- US $30.00-28.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.0% up
- Supply Ability
- 50 tons per month
- Release date
- 2022-10-21
- Product
- 2-(6-Aminopurin-9-yl)ethanol 707-99-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2019-09-04