ChemicalBook > CAS DataBase List > Sodium ethoxide

Sodium ethoxide

Product Name
Sodium ethoxide
CAS No.
141-52-6
Chemical Name
Sodium ethoxide
Synonyms
NaOEt;SODIUM ETHANOLATE;EtONa;SODIUM ETHYLATE;NE-21;ethoxysodium;Sodium ethoxide solution;Sodium ethoxide-ethanol solution;JACS-141-52-6;causticalcohol
CBNumber
CB6100652
Molecular Formula
C2H5NaO
Formula Weight
68.05
MOL File
141-52-6.mol
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Sodium ethoxide Property

Melting point:
260 °C
Boiling point:
91°C
Density 
0.868 g/mL at 25 °C
vapor density 
1.6 (vs air)
vapor pressure 
<0.1 mm Hg ( 20 °C)
refractive index 
n20/D 1.386
Flash point:
48 °F
storage temp. 
Store at +15°C to +25°C.
solubility 
Soluble in ethanol and methanol.
form 
Liquid
Specific Gravity
0.868
color 
Yellow to brown
PH
13 (5g/l, H2O, 20℃)
Water Solubility 
Miscible
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Merck 
14,8539
BRN 
3593646
Exposure limits
ACGIH: STEL 1000 ppm
OSHA: TWA 1000 ppm(1900 mg/m3)
NIOSH: IDLH 3300 ppm; TWA 1000 ppm(1900 mg/m3)
Stability:
Reacts violently with acids, water. Incompatible with chlorinated solvents, moisture. Absorbs carbon dioxide from the air. Highly flammable.
CAS DataBase Reference
141-52-6(CAS DataBase Reference)
EPA Substance Registry System
Ethanol, sodium salt (141-52-6)
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Safety

Hazard Codes 
F,C,Xi,N
Risk Statements 
11-14-34-36/37/38-68/20/21/22-51/53-20/21/22
Safety Statements 
8-16-26-43-45-36/37/39-36-61
RIDADR 
UN 3274 3/PG 2
WGK Germany 
1
F 
3-8-10-23
Autoignition Temperature
30 - 50 °C
TSCA 
Yes
HazardClass 
4.2
PackingGroup 
II
HS Code 
29051900
Hazardous Substances Data
141-52-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 598 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H251Self-heating; may catch fire

H314Causes severe skin burns and eye damage

H371May cause damage to organs

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18199
Product name
Sodium ethoxide
Purity
(20% solution in ethanol) for synthesis
Packaging
100ML
Price
$38
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18199
Product name
Sodium ethoxide
Purity
(20% solution in ethanol) for synthesis
Packaging
1L
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18199
Product name
Sodium ethoxide
Purity
(20% solution in ethanol) for synthesis
Packaging
50KG
Price
$1940
Updated
2024/03/01
Sigma-Aldrich
Product number
156248
Product name
Sodium ethoxide
Purity
95%
Packaging
5g
Price
$51.9
Updated
2024/03/01
Sigma-Aldrich
Product number
156248
Product name
Sodium ethoxide
Purity
95%
Packaging
100g
Price
$69.9
Updated
2024/03/01
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Sodium ethoxide Chemical Properties,Usage,Production

Chemical Properties

White powder, sometimes having brownish tinge; readily hydrolyzes to alcohol and sodium hydroxide.

Physical properties

White or yellowish powder; hygroscopic; darkens and decomposes on exposure to air; decomposes in water forming sodium hydroxide and ethanol; dissolves in absolute ethanol.

Uses

Sodium ethoxide is used in organic synthesis for condensation reactions. It also is a catalyst in many organic reactions.

Uses

Sodium ethoxide, 21% w/w in ethanol is used as a strong base in organic synthesis. It finds application in various chemical reactions such as condensation, esterification, alkoxylation and etherifcation. It is actively involved in Claisen condensation, Stobbe reaction and Wolf-kishner reduction. It is an important starting material for the synthesis of ethyl ester and diethyl ester of malonic acid. In Williamson ether synthesis, it reacts with ethyl bromide to form diethyl ether.

Definition

ChEBI: An organic monosodium salt that has ethoxide as the counterion.

Preparation

Sodium ethoxide is prepared by reacting sodium with absolute ethanol:
2Na + 2C2H5OH → 2C2H5ONa + H2
Sodium in small quantities is added to absolute alcohol at 10°C. The temperature is raised to warming (to about 38°C). The mixture is cooled again and sodium and absolute alcohol are added gradually followed by careful warming. The process is repeated to obtain a sufficient yield of the p

General Description

Sodium ethoxide is an alkoxide salt mainly used as a strong base in organic reactions such as deprotonation, dehydration and dehalogenation.

Hazard

As for caustic soda, ethanol. Sodium hydroxide is formed when sodium ethylate is exposed to moisture.

Flammability and Explosibility

Highly flammable

Purification Methods

It is a hygroscopic powder which should be stored under N2 in a cool place. A likely impurity is EtOH which can be removed by warming at 60-80o under high vacuum. It is hydrolysed by H2O to yield NaOH and EtOH. Other impurities, if kept in air for long periods are NaOH and Na2CO3. In this case the powder cannot be used if these impurities affect the reactivity, and a fresh sample should be acquired [IR: Seubold J Org Chem 21 156 1956]. [Beilstein 1 H 311, 1 IV 1289.]

Sodium ethoxide Preparation Products And Raw materials

Raw materials

Ethanol Solid sodium hydroxide Cyclohexane DL-1-Phenethylalcohol Sodium Dehydrolyzing agent weak Sodium hydroxide

Preparation Products

Diethyl dipropylmalonate Ethametsulfuron-methyl Dimethyl ethylmalonate Triamterene Diethyl isoamylmalonate 2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER ETHYL ISONICOTINOYLACETATE 2-Methoxy-3-methylpyrazine 2-HYDRAZINO-6-METHYLPYRIMIDIN-4-OL 2-ETHOXY-MALONIC ACID DIETHYL ESTER 2-METHYLUNDECANAL 2,4-DIETHOXYPYRIMIDINE 2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid 3-CARBETHOXY-2-PIPERIDONE HYDROXYLAMINE 2,4,6-TRIAMINO-5-NITROPYRIMIDINE Polysorbate 20 Methyltriethoxysilane P-AMINO-DL-PHENYLALANINE Diethyl butylmalonate UNICONAZOLE Gliclazide Cyclobutanemethanol 3-Furoic acid polysorbate 40 nony phenyl polyoxyethylene (50～150) ether DIETHYL 2-(2-CYANOETHYL)MALONATE 2-Amino-4,6-dihydroxypyrimidine 4-TERT-BUTYL-2,6-DIMETHYL BENZYL ACETATE Tween 80 NAFRONYL Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI) 4-(4-FLUOROBENZYLOXY)BENZALDEHYDE TRIETHYL 1,1,2-ETHANETRICARBOXYLATE 2-(2-MORPHOLIN-4-YLETHOXY)ANILINE 3-Aminopyrrolidine Ethyl 3-methyl-3-phenylglycidate 2-Ethoxythiazole FEMA 2310 N4-Methylcytosine
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View Lastest Price from Sodium ethoxide manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
SODIUM ETHOXIDE 141-52-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-08
Hebei Mojin Biotechnology Co., Ltd
Product
Sodium ethoxide 141-52-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07
Hebei Fengqiang Trading Co., LTD
Product
Sodium ethoxide 141-52-6
Price
US $100.00/drum
Min. Order
1drum
Purity
99
Supply Ability
5000
Release date
2023-08-28

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