7-bromoindolin-2-one
Preparation- Product Name
- 7-bromoindolin-2-one
- CAS No.
- 320734-35-8
- Chemical Name
- 7-bromoindolin-2-one
- Synonyms
- 7-bromoindolin-2-one;7-BROMOOXINDOLE;7-CHLOROOXINDOLE;7-Bromo-2-oxindole;7-Bromo-2-indolinone;7-chloro-1H-indol-2-ol;7-BroMo-1,3-dihydro-indol-2-one;7-Chloro-1,3-dihydro-indol-2-one;7-bromo-2,3-dihydro-1H-indol-2-one;7-Bromo-1,3-dihydro-2H-indol-2-one
- CBNumber
- CB6106366
- Molecular Formula
- C8H6BrNO
- Formula Weight
- 212.04
- MOL File
- 320734-35-8.mol
7-bromoindolin-2-one Property
- Melting point:
- 194-200°C
- Boiling point:
- 358.8±42.0 °C(Predicted)
- Density
- 1.666±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 13.22±0.20(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C8H6BrNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11)
- InChIKey
- WSUWXWBRIBGIQT-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2Br)CC1=O
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B5097
- Product name
- 7-Bromooxindole
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $62
- Updated
- 2025/07/31
- Product number
- B5097
- Product name
- 7-Bromooxindole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $187
- Updated
- 2025/07/31
- Product number
- B687993
- Product name
- 7-Bromooxindole
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W000051
- Product name
- 7-Bromooxindole
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- FB140214
- Product name
- 7-Bromoindolin-2-one
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
7-bromoindolin-2-one Chemical Properties,Usage,Production
Preparation
STEP A: Preparation of 7-chloro-3-hydrazono-oxindole. A solution of 25.0 g of 7-chloro-isatin in 250 ml of ethanol is refluxed for 24 hours, cooled, and precipitate recovered by filtering and washed once with ethanol and twice with pentane to obtain 7-chloro-3-hydrazono oxindole, m.p. 217-219℃. (decomp.). STEP B: Preparation of 7-chloro-oxindole. To a solution of sodium ethoxide prepared by heating 5.5 g of sodium in 200 ml. of ethanol at 70°℃. is added 17 g of 7-chloro-3-hydrazono-oxindole over a period of 3.5 hours, and the resulting solution is heated at 70℃. for 24 hours. The solvent is evaporated in vacuo, the residue dissolved in water, acidified with 6 N-hydro chloric acid and the resulting precipitate recovered by filtering, washed three times with water, dried by suc tion and crystallized from methylene chloride/ether to obtain 7-chlorooxindole, 28-220℃.
Synthesis
20780-74-9
320734-35-8
GENERAL PROCEDURE: Titanium tetrachloride (0.7 mL, 6 mmol) was slowly added to a stirred suspension of zinc powder (0.78 g, 12 mmol) in freshly distilled anhydrous tetrahydrofuran (15 mL) at room temperature and under a dry nitrogen atmosphere. After addition, the mixture was refluxed for 2 hours. After the formed suspension of low-valent titanium reagent was cooled to room temperature, a solution of 7-bromoindigo red (2 mmol) in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred at room temperature for about 5 min under nitrogen protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% hydrochloric acid (15 mL) and subsequently extracted with chloroform (3 x 50 mL). The combined organic phases were washed with water (3 x 50 mL) and dried over anhydrous sodium sulfate. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate = 5:1) to give pure 7-bromoindolone.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242
[2] Tetrahedron Letters, 2000, vol. 41, # 47, p. 9089 - 9093
[3] Journal of Chemical Research, 2017, vol. 41, # 9, p. 537 - 540
[4] Patent: WO2017/199265, 2017, A1. Location in patent: Paragraph 000170
7-bromoindolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
7-bromoindolin-2-one Suppliers
- Tel
- 021-50795510 4000665055
- sy-c6@accelachem.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- 86-021-50318510
- Fax
- 021-58650104
- Country
- China
- ProdList
- 69
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 027- 51832457 94518350
- Fax
- E-Mail Inquiry
- Country
- China
- ProdList
- 746
- Advantage
- 62
- Tel
- 021-50718719 13918719472
- Fax
- 021-50718719
- Country
- China
- ProdList
- 979
- Advantage
- 58
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 4132
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2336
- Advantage
- 58
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 400-8706899
- Fax
- 400-8706899
- hysj_bj.com
- Country
- China
- ProdList
- 3583
- Advantage
- 55
- Tel
- 18136598690 18136597130
- Fax
- 86-0519-89617886
- Country
- China
- ProdList
- 235
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0519-0519-83812535
- sales@qinuochem.com
- Country
- China
- ProdList
- 287
- Advantage
- 60
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 027-67849912
- Fax
- 027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 9148
- Advantage
- 60
- Tel
- 027-65388397 18164111589
- Fax
- 027-65388397
- 3321478047@qq.com
- Country
- China
- ProdList
- 2007
- Advantage
- 55
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1853
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5001
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 025-66162170
- Fax
- 025-66162170
- Country
- China
- ProdList
- 7181
- Advantage
- 55
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10295
- Advantage
- 58
- Tel
- 19951936396
- 1815156226@qq.com
- Country
- China
- ProdList
- 2947
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 021-67121386, 800-988-0390
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 5391
- Advantage
- 58
View Lastest Price from 7-bromoindolin-2-one manufacturers
- Product
- 7-bromoindolin-2-one 320734-35-8
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 7-bromoindolin-2-one 320734-35-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 7-bromoindolin-2-one 320734-35-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09