1-METHYLURIC ACID

Product Name: 1-METHYLURIC ACID
CAS No.: 708-79-2
Chemical Name: 1-METHYLURIC ACID
Synonyms: 1-U;1MUA;1-METHYLURIC ACID;1-Methyluric acid ,98%;Theophylline Impurity 17;1-METHYLURIC ACID USP/EP/BP;1-METHYL-2,6,8-TRIHYDROXYPURINE;1-Methyl-1H-purine-2,6,8(3H,7H,9H)-trione;1-methyl-7,9-dihydro-3H-purine-2,6,8-trione;7,9-dihydro-1-methyl-1H-purine-2,6,8(3H)-trione
CBNumber: CB6107257
Molecular Formula: C6H6N4O3
Formula Weight: 182.14
MOL File: 708-79-2.mol

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1-METHYLURIC ACID Property

Melting point:: >325°C
Boiling point:: 315.51°C (rough estimate)
Density: 1.5283 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Refrigerator
solubility: Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
form: Solid
pka: 5.60±0.50(Predicted)
color: Pale Yellow to Pale Brown
Water Solubility: 1.585g/L(temperature not stated)
BRN: 195190

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Safety

WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6885
Product name: 1-Methyluric acid
Packaging: 50mg
Price: $146
Updated: 2023/01/07

Sigma-Aldrich

Product number: M6885
Product name: 1-Methyluric acid
Packaging: 100mg
Price: $259
Updated: 2023/01/07

Usbiological

Product number: 017570
Product name: 1-Methyluric Acid
Packaging: 10mg
Price: $340
Updated: 2021/12/16

Usbiological

Product number: 281677
Product name: 1-Methyluric acid
Packaging: 25mg
Price: $375
Updated: 2021/12/16

TRC

Product number: M338180
Product name: 1-Methyluric acid
Packaging: 25mg
Price: $135
Updated: 2021/12/16

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1-METHYLURIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

1-Methyluric acid, a metabolite of Theophylline, has been used:
for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
in turbidimetric assay of synthetic urine samples
as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay

Definition

ChEBI: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.

Biochem/physiol Actions

1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.

Purification Methods

Recrystallise it from H2O. Its solubility at 17.5o is 1g in 353mL of H2O. [Bergmann & Dikstein J Am Chem Soc 77 691 1955.] It has UV: max at 231 and 283nm (pH 3), and 217.5 and 292.5nm (pH >12) [Johnson Biochem J 5 133 1952]. [Beilstein 26 II 299, 26 III/IV 2621.]

1-METHYLURIC ACID Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid N,N-Dimethylformamide Palladium hydroxide Sodium acetate trihydrate Triethyl orthoformate Sodium Sodium nitrite Acetic acid Sodium hydroxide Ethyl cyanoacetate Thiourea Dimethyl sulfate

Preparation Products

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1-METHYLURIC ACID Suppliers

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708-79-2, 1-METHYLURIC ACIDRelated Search:

p-Toluic acid Methylcyclohexane Theanine Chlorotrimethylsilane Tetramethyl uric acid Uric acid 1-METHYLURIC ACID 1,3,7-TRIMETHYLURIC ACID TETRAMETHYLURIC ACID 1,3-Dimethyluric acid 9-METHYLURIC ACID 1,9-DIMETHYL-2,6,8-TRIHYDROXYPURINE [7-CD3]-1,3,7-Trimethyluric Acid 1-METHYLURIC ACID-D3 1,7-DIMETHYLURIC ACID 7-METHYLURIC ACID 3-METHYLURIC ACID

1-METHYLURIC ACID

1-METHYL-2,6,8-TRIHYDROXYPURINE

7,9-dihydro-1-methyl-1H-purine-2,6,8(3H)-trione

1-methyl-7,9-dihydro-3H-purine-2,6,8-trione

1-Methyluric acid ,98%

1-Methyluric acid,1-Methyl-2,6,8-trihydroxypurine

1MUA

1-U

1-Methyl-1H-purine-2,6,8(3H,7H,9H)-trione

Theophylline Impurity 17

1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-1-methyl-

1-METHYLURIC ACID USP/EP/BP

708-79-2

Biochemicals and Reagents

Building Blocks

BioChemical

Heterocyclic Building Blocks

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Purines

Bases & Related Reagents

Heterocycles

Metabolites & Impurities

Nucleotides

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

Purines