2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Product Name: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
CAS No.: 302964-24-5
Chemical Name: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Synonyms: EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth
CBNumber: CB61090897
Molecular Formula: C11H10ClN3OS
Formula Weight: 267.73
MOL File: 302964-24-5.mol

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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Property

Melting point:: 208.0 to 212.0 °C
Boiling point:: 362.0±37.0 °C(Predicted)
Density: 1.474±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Sparingly)
form: powder to crystal
pka: 11.09±0.70(Predicted)
color: White to Light yellow
InChI: InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)
InChIKey: VVOXTERFTAJMAA-UHFFFAOYSA-N
SMILES: S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N
CAS DataBase Reference: 302964-24-5(CAS DataBase Reference)

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Safety

HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2773
Product name: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $41
Updated: 2024/03/01

TCI Chemical

Product number: A2773
Product name: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2024/03/01

TRC

Product number: A603910
Product name: 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide
Packaging: 10g
Price: $1455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029530
Product name: 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $846.5
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-5-X5
Product name: 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Purity: 98%
Packaging: 100g
Price: $1149
Updated: 2021/12/16

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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemical Properties,Usage,Production

Uses

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib (D193600), a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs.

Synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Suppliers

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Carbosynth

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Melrob Ltd (part of Nordmann)

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View Lastest Price from 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2-amino-N-(2-chloro-6-methyl-phenyl)thiazole-5-carboxamide 302964-24-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide 302964-24-5
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 302964-24-5
Price: US $6.00-0.20/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

302964-24-5, 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamideRelated Search:

Dacomitinib (PF299804) Methyl 2-aminothiazole-5-carboxylate ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Dasatinib monohydrate (E)-3-Ethoxyacryloyl chloride N,N-Dimethylformamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib ALTRENOGEST Epichlorohydrin N-Methylformamide Glycine N-Deshydroxyethyl Dasatinib Dasatinib Impurity 33 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98%

Dasatinib IMpurity 2

2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carboxiMide)

2-Amino-5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazole, 2-Amino-5-[(6-chloro-o-tolyl)carbamoyl]-1,3-thiazole

5-ThiazolecarboxaMide,2-aMino-N-(2-chloro-6-Methylphenyl)

Dasatinib Int N-2

2-AMino-N-(2-chloro-6-Meth

2-AMino-N-(2-chloro-6-Methylphenyl)-5-thiazolecarboxaMide

2-Amino-<i>N</i>-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Intermediate of Dasatinib)

2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE

EOS-61515

The dimer impurity

Dasatinib Impurity 27

2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carb

2-aMino-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide

dasatinib interMediate

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide &gt

2-Amino-N-(2-chL

Dasatinib Aminothiazole Impurity

2- Amino-N - (2-chloro-6-methylphenyl) thiazole-5-carboxylamide

Dasatinib Impurity L

2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazol-5-carboxamide

2-Amino-N - (2-chloro-6-methylphenyl) -5-thiazolamide

Dasatinib EP Impurity-A

302964-24-5

392064-08-5

Dasatinib

API intermediates