Potassium 3-methoxy-3-oxopropanoate
- Product Name
- Potassium 3-methoxy-3-oxopropanoate
- CAS No.
- 38330-80-2
- Chemical Name
- Potassium 3-methoxy-3-oxopropanoate
- Synonyms
- METHYL POTASSIUM MALONATE;POTASSIUM MONOMETHYL MALONATE;MONOMETHYL MONOPOTASSIUM MALONATE;POTASSIUM METHYL MALONATE;MONO-METHYL MALONATE POTASSIUM SALT;KMM;Potassium 3-methoxy-;Potassiummonomethylmallonate;Methyl potassium malonate 98%;Monomethyl Potassium Malonate
- CBNumber
- CB6123891
- Molecular Formula
- C4H5KO4
- Formula Weight
- 156.18
- MOL File
- 38330-80-2.mol
Potassium 3-methoxy-3-oxopropanoate Property
- Melting point:
- 200 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in methanol.
- form
- Crystalline Powder
- color
- White
- PH
- pH(50g/l, 25℃) : 5.5～8.0
- BRN
- 3633585
- InChI
- InChI=1S/C4H6O4.K/c1-8-4(7)2-3(5)6;/h2H2,1H3,(H,5,6);/q;+1/p-1
- InChIKey
- WWTULTKUWBKVGV-UHFFFAOYSA-M
- SMILES
- C(=O)(OC)CC([O-])=O.[K+]
- CAS DataBase Reference
- 38330-80-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H304May be fatal if swallowed and enters airways
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331Do NOT induce vomiting.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 63405
- Product name
- Methyl potassium malonate
- Purity
- ≥99.0% (NT)
- Packaging
- 250g
- Price
- $142.8
- Updated
- 2025/07/31
- Product number
- 63405
- Product name
- Methyl potassium malonate
- Purity
- ≥99.0% (NT)
- Packaging
- 50g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- M2149
- Product name
- Monomethyl Potassium Malonate
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- M2149
- Product name
- Monomethyl Potassium Malonate
- Purity
- >98.0%(T)
- Packaging
- 250g
- Price
- $241
- Updated
- 2025/07/31
- Product number
- 278997
- Product name
- Hydrogen methyl malonate potassium salt
- Packaging
- 50g
- Price
- $342
- Updated
- 2021/12/16
Potassium 3-methoxy-3-oxopropanoate Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
Methyl potassium malonate is a protein advanced glycosylation inhibitor.
Uses
Methyl potassium malonate can be used in the total synthesis of (±)-vincorine, an akuammiline alkaloid which can find applications in biology. It can also be used to synthesize a key keto proline ester intermediate to prepare acutumine.
Synthesis
108-59-8
38330-80-2
The general procedure for the synthesis of monomethyl malonate potassium salt from dimethyl malonate was as follows: referring to the literature method, dimethyl malonate (40.0 mmol), water (40.0 mmol), and ethanol (45 mL) were added to a 250 mL two-necked round-bottomed flask, and the mixture was stirred and mixed. The mixture was reacted in an oil bath at 40°C for 2 hours. Subsequently, a solution of potassium tert-butoxide (40.0 mmol) in ethanol (45 mL) was slowly added dropwise over 30 minutes. After the dropwise addition, the reaction was continued with stirring in a 40°C oil bath until the feedstock was completely consumed (the progress of the reaction was monitored by GC analysis). Upon completion of the reaction, the ethanol solvent was slowly evaporated using a rotary evaporator, followed by the addition of 20 mL of diethyl ether. The resulting solid product was collected by filtration and washed sequentially with a 1:1 mixture of ether and ethanol (5 mL × 2) and pure ether (10 mL × 3). The washed solid was transferred to a round-bottomed flask and dried under vacuum at 50 °C for 10 h. The final potassium salt of monomethyl malonate was obtained in 85% yield.
References
[1] Tetrahedron, 2012, vol. 68, # 9, p. 2113 - 2120
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 19, p. 4470 - 4474
[3] Patent: CN106467492, 2017, A. Location in patent: Paragraph 0129; 0130; 0131
[4] Journal of Physical Chemistry, 1987, vol. 91, # 19, p. 5129 - 5134
[5] Patent: US6172257, 2001, B2
Potassium 3-methoxy-3-oxopropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Potassium 3-methoxy-3-oxopropanoate Suppliers
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- 800-4238616
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View Lastest Price from Potassium 3-methoxy-3-oxopropanoate manufacturers
- Product
- Potassium 3-methoxy-3-oxopropanoate 38330-80-2
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000
- Release date
- 2024-08-15
- Product
- Potassium 3-methoxy-3-oxopropanoate 38330-80-2
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- Potassium 3-methoxy-3-oxopropanoate 38330-80-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29