ChemicalBook > CAS DataBase List > Amprolium

Amprolium

Product Name
Amprolium
CAS No.
121-25-5
Chemical Name
Amprolium
Synonyms
AMPROLIUM;Amprolium HCI;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.;1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride
CBNumber
CB6127743
Molecular Formula
C14H19N4.Cl
Formula Weight
278.79
MOL File
121-25-5.mol
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Amprolium Property

Melting point:
246-248 °C (decomp)
storage temp. 
0-6°C
solubility 
Soluble in DMSO
color 
Crystals from methanol + ethanol
Stability:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChI
InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey
LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES
C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS DataBase Reference
121-25-5(CAS DataBase Reference)
EPA Substance Registry System
Amprolium (121-25-5)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2345
Product name
Amprolium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$200
Updated
2024/03/01
TRC
Product number
A634413
Product name
Amprolium
Packaging
2.5mg
Price
$45
Updated
2021/12/16
TRC
Product number
A634413
Product name
Amprolium
Packaging
5mg
Price
$60
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
18478
Product name
Amprolium
Packaging
25mg
Price
$1500
Updated
2021/12/16
Crysdot
Product number
CD31004266
Product name
Amprolium
Purity
98+%
Packaging
100mg
Price
$50
Updated
2021/12/16
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Amprolium Chemical Properties,Usage,Production

Description

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Chemical Properties

solid

Originator

Neoprol ,SIMB

Uses

Coccidiostat (for poultry).

Uses

Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.

Definition

ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.

Manufacturing Process

1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).

brand name

Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).

Therapeutic Function

Coccidiostatic

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Side effects

Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.

Safety Profile

When heated to decomposition emits toxic fumes of Cl-.

Amprolium Preparation Products And Raw materials

Raw materials

Preparation Products

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Amprolium Suppliers

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View Lastest Price from Amprolium manufacturers

shandong perfect biotechnology co.ltd
Product
amprolium hydrochloride 121-25-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
5 ton
Release date
2023-07-06
Hebei Fengqiang Trading Co., LTD
Product
Amprolium 121-25-5
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-08-11
Hebei Mojin Biotechnology Co., Ltd
Product
Amprolium 121-25-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20

121-25-5, AmproliumRelated Search:


  • AMPROLIUM
  • 1-[[4-Amino-2-propyl-5-pyrimidinyl] methyl]-2-picolinium chloride hydrochloride
  • 1-[2-Propyl-4-amino-5-pyrimidylmethyl]-2-methylpyridinium chloride hydrochloride
  • Pyridinium, 1-(4-amino-2-propyl-5-pyrimidinyl)methyl-2-methyl-, chloride
  • AMPROLIUM USP 26, BPV 98
  • (1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.
  • 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride
  • 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride
  • 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride
  • Amprolium [INN:BAN]
  • AMproliuM, USP
  • [5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-yl]amine chloride
  • 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine chloride
  • 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride
  • (1R,2S,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalene-1,2-diol
  • Amprolium USP/EP/BP
  • 1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride
  • amprolium/amprolium hydrochloride
  • Venlafaxine Impurity 1-d6
  • Amprolium HCI
  • 121-25-5
  • C14H19CIN4HCl
  • C14H19ClN4
  • APIs
  • API's