Amprolium

ChemicalBook > CAS DataBase List > Amprolium

Product Name: Amprolium
CAS No.: 121-25-5
Chemical Name: Amprolium
Synonyms: AMPROLIUM;Amprolium HCI;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.;1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride
CBNumber: CB6127743
Molecular Formula: C14H19N4.Cl
Formula Weight: 278.79
MOL File: 121-25-5.mol

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Amprolium Property

Melting point:: 246-248 °C (decomp)
storage temp.: 0-6°C
solubility: Soluble in DMSO
color: Crystals from methanol + ethanol
Stability:: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChI: InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey: LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES: C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS DataBase Reference: 121-25-5(CAS DataBase Reference)
EPA Substance Registry System: Amprolium (121-25-5)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2345
Product name: Amprolium
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: $200
Updated: 2024/03/01

TRC

Product number: A634413
Product name: Amprolium
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A634413
Product name: Amprolium
Packaging: 5mg
Price: $60
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18478
Product name: Amprolium
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

Crysdot

Product number: CD31004266
Product name: Amprolium
Purity: 98+%
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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Amprolium Chemical Properties,Usage,Production

Description

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Chemical Properties

solid

Originator

Neoprol ,SIMB

Uses

Coccidiostat (for poultry).

Uses

Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.

Definition

ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.

Manufacturing Process

1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).

brand name

Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).

Therapeutic Function

Coccidiostatic

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Side effects

Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.

Safety Profile

When heated to decomposition emits toxic fumes of Cl-.

Amprolium Preparation Products And Raw materials

Raw materials

Preparation Products

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Amprolium Suppliers

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View Lastest Price from Amprolium manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Amprolium 121-25-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

shandong perfect biotechnology co.ltd

Product: amprolium hydrochloride 121-25-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 5 ton
Release date: 2023-07-06

Hebei Fengjia New Material Co., Ltd

Product: Amprolium 121-25-5
Price: US $120.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000
Release date: 2024-08-15

121-25-5, AmproliumRelated Search:

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AMPROLIUM

1-[[4-Amino-2-propyl-5-pyrimidinyl] methyl]-2-picolinium chloride hydrochloride

1-[2-Propyl-4-amino-5-pyrimidylmethyl]-2-methylpyridinium chloride hydrochloride

Pyridinium, 1-(4-amino-2-propyl-5-pyrimidinyl)methyl-2-methyl-, chloride

AMPROLIUM USP 26, BPV 98

(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.

1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride

1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride

1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride

Amprolium [INN:BAN]

AMproliuM, USP

[5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-yl]amine chloride

5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine chloride

5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride

(1R,2S,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalene-1,2-diol

Amprolium USP/EP/BP

1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride

amprolium/amprolium hydrochloride

Amprolium HCI

Venlafaxine Impurity 1-d6

121-25-5

C14H19CIN4HCl

C14H19ClN4

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