Amprolium
- Product Name
- Amprolium
- CAS No.
- 121-25-5
- Chemical Name
- Amprolium
- Synonyms
- AMPROLIUM;Amprolium HCI;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.;1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride
- CBNumber
- CB6127743
- Molecular Formula
- C14H19N4.Cl
- Formula Weight
- 278.79
- MOL File
- 121-25-5.mol
Amprolium Property
- Melting point:
- 246-248 °C (decomp)
- storage temp.
- 0-6°C
- solubility
- Soluble in DMSO
- color
- Crystals from methanol + ethanol
- Stability:
- Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
- InChI
- InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
- InChIKey
- LCTXBFGHZLGBNU-UHFFFAOYSA-M
- SMILES
- C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
- CAS DataBase Reference
- 121-25-5(CAS DataBase Reference)
- EPA Substance Registry System
- Amprolium (121-25-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR2345
- Product name
- Amprolium
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500MG
- Price
- $200
- Updated
- 2024/03/01
- Product number
- A634413
- Product name
- Amprolium
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A634413
- Product name
- Amprolium
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 18478
- Product name
- Amprolium
- Packaging
- 25mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- CD31004266
- Product name
- Amprolium
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
Amprolium Chemical Properties,Usage,Production
Description
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Chemical Properties
solid
Originator
Neoprol ,SIMB
Uses
Coccidiostat (for poultry).
Uses
Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.
Definition
ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.
Manufacturing Process
1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).
brand name
Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).
Therapeutic Function
Coccidiostatic
Contact allergens
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Side effects
Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.
Safety Profile
When heated to decomposition emits toxic fumes of Cl-.
Amprolium Preparation Products And Raw materials
Raw materials
Preparation Products
Amprolium Suppliers
View Lastest Price from Amprolium manufacturers
- Product
- amprolium hydrochloride 121-25-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 5 ton
- Release date
- 2023-07-06
- Product
- Amprolium 121-25-5
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-08-11
- Product
- Amprolium 121-25-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20