ChemicalBook > CAS DataBase List > FMOC-D-Valine

FMOC-D-Valine

Product Name
FMOC-D-Valine
CAS No.
84624-17-9
Chemical Name
FMOC-D-Valine
Synonyms
FMOC-D-VAL-OH;FMOC-D-VAL;(R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid;FMOC-D-VALINE;FMco-D-Val-OH;N-FMOC-D-VALINE;FMOC-D-VALINE 98%;(R)-N-Fmoc-valine;Fmoc-D-Val-OH,98%;Fmoc-D-Val-OH 98%
CBNumber
CB6133511
Molecular Formula
C20H21NO4
Formula Weight
339.39
MOL File
84624-17-9.mol
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FMOC-D-Valine Property

Melting point:
143-144 °C(lit.)
alpha 
17 º (c=1, DMF)
Boiling point:
551.8±33.0 °C(Predicted)
Density 
1.229±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.90±0.10(Predicted)
color 
White
optical activity
Consistent with structure
Water Solubility 
Solubility in methanol (almost transparency). Slightly soluble in water.
BRN 
6489548
CAS DataBase Reference
84624-17-9(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2924 29 70
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem?
Packaging
5G
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem?
Packaging
25g
Price
$416
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1000
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1000
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$3370
Updated
2025/07/31
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FMOC-D-Valine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

640-68-6

28920-43-6

84624-17-9

General procedure for the synthesis of Fmoc-D-valine from D-valine and chloroformic acid-9-fluorenylmethyl ester: A 500 mL three-necked flask was taken, and D-valine (4.5 g, 38.9 mmol), dioxane (40 mL), and 10% aqueous sodium carbonate (100 mL) were added sequentially. The reaction system was placed in an ice bath and mechanical stirring was initiated. A dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.8 mmol) was prepared in a dropping funnel and slowly added dropwise to the reaction vial. After the dropwise addition was completed, it was gradually brought to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added to the reaction mixture and extracted three times with 50 mL of ether and the organic phase was discarded. The aqueous phase was cooled in an ice bath, and the pH was adjusted to 1 by slowly adding 1 M dilute hydrochloric acid, followed by extracting the aqueous phase with 50 mL ethyl acetate three times, combining the organic phases and drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the organic phase was concentrated under reduced pressure to give the white solid product Fmoc-D-valine (12.6 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0172; 0173; 0174
[2] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531

FMOC-D-Valine Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-D-Valine Suppliers

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View Lastest Price from FMOC-D-Valine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
FMOC-D-Valine 84624-17-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2023-01-05
Hebei Fengjia New Material Co., Ltd
Product
FMOC-D-Valine 84624-17-9
Price
US $120.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000000
Release date
2024-08-15
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-D-Val-OH 84624-17-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-11

84624-17-9, FMOC-D-ValineRelated Search:

L-Valine Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate Valine Glycine Fmoc-Aib-OH D-Valine Fmoc-Lys(Boc)-OH Fmoc-D-Ile-OH Fmoc-Phe-OH 1,1'-Carbonyldiimidazole L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-D-glutamic acid gamma-tert-butyl ester Fmoc-OSu FMOC-L-Valine Fmoc Carbonyl iron powder NICKEL CARBONYL

  • Fmoc-D-Val-OH >=98.0% (HPLC)
  • (R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid
  • Fmoc-D-valine≥ 99% (HPLC)
  • N-FMOC-D-VALINE
  • 2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-methylbutanoic acid
  • (R)-2-(Fmoc-amino)-3-methylbutyric Acid
  • (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-VALINE
  • N-9-FLUORENYLMETHYLOXYCARBONYL-D-VALINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-VALINE
  • N-ALPHA-FMOC-D-VALINE
  • FMOC-D-VAL-OH
  • FMOC-D-VAL
  • FMOC-D-VALINE
  • 9-FLUORENYLMETHOXYCARBONYL-D-VALINE
  • FMOC-D-VALINE 98%
  • FLUORENYLMETHOXYCARBONYL-D-VALINE(FMOC-D-VAL-OH)
  • FMOC-D-VALINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-D-valine, Fmoc-D-valine
  • Nα-(9-Fluorenylmethyloxycarbonyl)-D-valine ,99%
  • 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylbutanoic acid
  • Fmoc-D-valine ,99%
  • FMco-D-Val-OH
  • N-Fmoc-D-valine Fmoc-D-Val-OH
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Val-OH
  • FMoc-D-Val-OH ,99%
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine&gt
  • D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • FMOC-D-Valine USP/EP/BP
  • (R)-N-Fmoc-valine
  • Fmoc-D-Val-OH,98%
  • Valine Impurity 2 (Fmoc-D-Val-OH)
  • Ensitrelvir Impurity 39
  • Fmoc-<sc>D</sc>-Val-OH
  • N-(9-fluorene methoxycarbonyl)- D-valine
  • Fmoc-D-Val-OH 98%
  • D-Valine, N-FMOC protected
  • 84624-17-9
  • 4624-17-9
  • Valine
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acid Derivatives
  • Valine [Val, V]
  • Fmoc-Amino Acids and Derivatives
  • Amino Acids (N-Protected)
  • Biochemistry
  • Fmoc-Amino Acids
  • Fmoc-Amino acid series
  • Fluorenes, Flurenones
  • Amino Acid Derivatives
  • Amino Acids