2-CHLORO-4-PHENYLPYRIMIDINE
- Product Name
- 2-CHLORO-4-PHENYLPYRIMIDINE
- CAS No.
- 13036-50-5
- Chemical Name
- 2-CHLORO-4-PHENYLPYRIMIDINE
- Synonyms
- 2-CHLORO-4-PHENYLPYRIMIDINE;2-chloro-4-phenyl-pyrimidin;2-Chloro-6-phenylpyrimidine;2-Chloro-4-phenylpyrimidine95%;Pyrimidine, 2-chloro-4-phenyl-
- CBNumber
- CB6141833
- Molecular Formula
- C10H7ClN2
- Formula Weight
- 190.63
- MOL File
- 13036-50-5.mol
2-CHLORO-4-PHENYLPYRIMIDINE Property
- Melting point:
- 86 °C
- Boiling point:
- 368.3±11.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- -1.38±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C350765
- Product name
- 2-Chloro-4-phenylpyrimidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H32-5-J6
- Product name
- 2-Chloro-4-phenylpyrimidine
- Purity
- 95%
- Packaging
- 10g
- Price
- $463
- Updated
- 2021/12/16
- Product number
- Z9498
- Product name
- 2-Chloro-4-phenylpyrimidine
- Packaging
- 10g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- 188023
- Product name
- 2-Chloro-4-phenylpyrimidine
- Packaging
- 10g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- HCH0019243
- Product name
- 2-CHLORO-4-PHENYLPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $708.48
- Updated
- 2021/12/16
2-CHLORO-4-PHENYLPYRIMIDINE Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 4137, 1988 DOI: 10.1021/jo00252a057
Synthesis
3934-20-1
98-80-6
13036-50-5
General procedure for the synthesis of 2-chloro-4-phenylpyrimidines from 2,4-dichloropyrimidines and phenylboronic acid: first, 2,4-dichloropyrimidines (5 g, 33.57 mmol) were dissolved in acetonitrile (60 ml), followed by the addition of water (15 ml). Next, phenylboronic acid (4.09 g, 33.57 mmol) and sodium carbonate (14.23 g, 134.28 mmol) were added to this solution. Degassing was carried out by blowing nitrogen into the reaction mixture for 10 minutes. After that, tetrakis(triphenylphosphine)palladium (354 mg, 0.34 mmol) was added. The reaction mixture was stirred under nitrogen protection at 90 °C for 18 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was collected. The solvent was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography with the eluent being a 10-15% ethyl acetate/petroleum ether solvent mixture, resulting in the target compound 2-chloro-4-phenylpyrimidine as a colorless solid (2.98 g, 47% yield). Mass spectrum (LRMS) [M + H]+ m/z: 191.1; 1H NMR (400 MHz, CDCl3) δ 8.62 (d, J = 5.3 Hz, 1H), 8.16-7.99 (m, 2H), 7.63 (d, J = 5.3 Hz, 1H), 7.50 (qdd, J = 6.0,3.2,1.4 Hz, 3H).
References
[1] Journal of Organometallic Chemistry, 2018, vol. 862, p. 76 - 85
[2] Patent: CN103819455, 2016, B. Location in patent: Paragraph 0067; 0084; 0085
[3] Patent: KR2015/34146, 2015, A. Location in patent: Paragraph 0059; 0076; 0077
[4] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[5] Patent: WO2011/93609, 2011, A1. Location in patent: Page/Page column 19
2-CHLORO-4-PHENYLPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-4-PHENYLPYRIMIDINE manufacturers
- Product
- 2-Chloro-4-phenylpyriMidine 13036-50-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2-CHLORO-4-PHENYLPYRIMIDINE 13036-50-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08