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2-CHLORO-4-PHENYLPYRIMIDINE

Product Name
2-CHLORO-4-PHENYLPYRIMIDINE
CAS No.
13036-50-5
Chemical Name
2-CHLORO-4-PHENYLPYRIMIDINE
Synonyms
2-CHLORO-4-PHENYLPYRIMIDINE;2-chloro-4-phenyl-pyrimidin;2-Chloro-6-phenylpyrimidine;2-Chloro-4-phenylpyrimidine95%;Pyrimidine, 2-chloro-4-phenyl-
CBNumber
CB6141833
Molecular Formula
C10H7ClN2
Formula Weight
190.63
MOL File
13036-50-5.mol
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2-CHLORO-4-PHENYLPYRIMIDINE Property

Melting point:
86 °C
Boiling point:
368.3±11.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
-1.38±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C350765
Product name
2-Chloro-4-phenylpyrimidine
Packaging
250mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR9304
Product name
2-Chloro-4-phenylpyrimidine
Purity
95%
Packaging
1g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-J6
Product name
2-Chloro-4-phenylpyrimidine
Purity
95%
Packaging
1g
Price
$112
Updated
2021/12/16
Apolloscientific
Product number
OR9304
Product name
2-Chloro-4-phenylpyrimidine
Purity
95%
Packaging
5g
Price
$165
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-J6
Product name
2-Chloro-4-phenylpyrimidine
Purity
95%
Packaging
5G
Price
$264
Updated
2021/12/16
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2-CHLORO-4-PHENYLPYRIMIDINE Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 4137, 1988 DOI: 10.1021/jo00252a057

Synthesis

3934-20-1

98-80-6

13036-50-5

General procedure for the synthesis of 2-chloro-4-phenylpyrimidines from 2,4-dichloropyrimidines and phenylboronic acid: first, 2,4-dichloropyrimidines (5 g, 33.57 mmol) were dissolved in acetonitrile (60 ml), followed by the addition of water (15 ml). Next, phenylboronic acid (4.09 g, 33.57 mmol) and sodium carbonate (14.23 g, 134.28 mmol) were added to this solution. Degassing was carried out by blowing nitrogen into the reaction mixture for 10 minutes. After that, tetrakis(triphenylphosphine)palladium (354 mg, 0.34 mmol) was added. The reaction mixture was stirred under nitrogen protection at 90 °C for 18 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was collected. The solvent was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography with the eluent being a 10-15% ethyl acetate/petroleum ether solvent mixture, resulting in the target compound 2-chloro-4-phenylpyrimidine as a colorless solid (2.98 g, 47% yield). Mass spectrum (LRMS) [M + H]+ m/z: 191.1; 1H NMR (400 MHz, CDCl3) δ 8.62 (d, J = 5.3 Hz, 1H), 8.16-7.99 (m, 2H), 7.63 (d, J = 5.3 Hz, 1H), 7.50 (qdd, J = 6.0,3.2,1.4 Hz, 3H).

References

[1] Journal of Organometallic Chemistry, 2018, vol. 862, p. 76 - 85
[2] Patent: CN103819455, 2016, B. Location in patent: Paragraph 0067; 0084; 0085
[3] Patent: KR2015/34146, 2015, A. Location in patent: Paragraph 0059; 0076; 0077
[4] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[5] Patent: WO2011/93609, 2011, A1. Location in patent: Page/Page column 19

2-CHLORO-4-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

2-PHENYLMALONDIALDEHYDE p-Toluenesulfonic acid Ethanol Sodium sulfate Phosphorus oxitrichloride N,N-Dimethylaniline Diethyl ether Benzene Hydrochloric acid Sodium bicarbonate Dichloromethane Sodium hydroxide Dimethylamine Magnesium sulfate UREA HYDROCHLORIDE Sodium carbonate

Preparation Products

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2-CHLORO-4-PHENYLPYRIMIDINE Suppliers

Belgium 1 China 69 Germany 2 India 2 The Netherlands 1 United Kingdom 1 United States 14 Global 90
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
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View Lastest Price from 2-CHLORO-4-PHENYLPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4-phenylpyriMidine 13036-50-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
2-CHLORO-4-PHENYLPYRIMIDINE 13036-50-5
Price
US $6.68/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

13036-50-5, 2-CHLORO-4-PHENYLPYRIMIDINERelated Search:

2-CHLORO-4-PHENYLPYRIMIDINE Ethyl 2-chloro-4-phenylpyrimidine-5-carboxylate ,97%,ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4-(3-Bromophenyl)-2-chloropyrimidine 2-AMINO-4-CHLORO-6-PHENYLPYRIMIDINE 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBONYL CHLORIDE 2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE 4-PHENYLIMIDAZOLE 2-CHLORO-6-METHYL-4-PHENYL-QUINAZOLINE 2,4-dichloro-6-phenylpyrimidine 2,6-DICHLORO-4-PHENYL-QUINAZOLINE 2-chloro-5-methyl-4-phenylpyrimidine 2-Chloro-4-(4-fluoro-phenyl)-pyrimidine 2-CHLORO-4-PHENYLQUINAZOLINE 6-BROMO-2-CHLORO-4-PHENYLQUINAZOLINE 2-Chloro-4,6-diphenylpyrimidine 4-CHLORO-6-PHENYLPYRIMIDINE 5-CHLORO-2-PHENYLPYRIMIDINE 6-AMINO-2-(4-BROMOPHENYL)-5-CHLOROPYRIMIDINE-4-CARBOXYLIC ACID

  • 2-chloro-4-phenyl-pyrimidin
  • 2-CHLORO-4-PHENYLPYRIMIDINE
  • Pyrimidine, 2-chloro-4-phenyl-
  • 2-Chloro-4-phenylpyrimidine95%
  • 2-Chloro-6-phenylpyrimidine
  • 13036-50-5
  • Amines
  • blocks
  • APIs & Intermediate
  • Pyrimidine
  • pharmacetical