ChemicalBook > CAS DataBase List > Dabigatran

Dabigatran

Product Name
Dabigatran
CAS No.
211914-51-1
Chemical Name
Dabigatran
Synonyms
BIB-953;CS-1864;BIBR 953;BIBR 953ZW;Dabigatran;Dabiga group;Dabigatran API;Dabigatran base;Dabigatran (Acid);Dabigatran(BIB-953
CBNumber
CB61458206
Molecular Formula
C25H25N7O3
Formula Weight
471.51
MOL File
211914-51-1.mol
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Dabigatran Property

Melting point:
268-272°C
Boiling point:
797.1±70.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Acid
form 
Solid
pka
4.17±0.10(Predicted)
color 
White to Brown
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Safety

Hazardous Substances Data
211914-51-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17133
Product name
Dabigatran
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17133
Product name
Dabigatran
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17133
Product name
Dabigatran
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
17133
Product name
Dabigatran
Purity
≥95%
Packaging
50mg
Price
$606
Updated
2024/03/01
TRC
Product number
D100090
Product name
Dabigatran
Packaging
50mg
Price
$525
Updated
2021/12/16
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Dabigatran Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

BIBR 953 (Dabigatran, Pradaxa) is potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-b ta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.

Biological Activity

bibr 953 is a potent, reversible, and direct inhibitor of thrombin with ic50 value of 9.3nm [1].bibr 953 shows a favorable selectivity profile and strong activity in vitro with a ki value of 4.5nm. it also exhibits the best activity profile in vivo following administration to rats. bibr 953 is designed to be converted into an orally active prodrug bibr 1048 due to its highly polar, zwitterionic nature and poor oral absorption. bibr 953 inhibits thrombin in a competitive fashion. this inhibition is rapid and reversible. bibr 953 inhibits both clot-bound and free thrombin. bibr 953 is demonstrated to have an anticoagulant efficacy both in vitro and ex vivo. since thrombin can affect cell behavior and response in various tissue types via par signaling, bibr 953 is found to be beneficial in many diseases including inflammation, infection, fibrosis and cancer.

target

thrombin

References

[1] hauel nh, nar h, priepke h, ries u, stassen jm, wienen w. structure-based design of novel potent nonpeptide thrombin inhibitors. j med chem. 2002 apr 25;45(9):1757-66.
[2] van ryn j, goss a, hauel n, wienen w, priepke h, nar h, clemens a. the discovery of dabigatran etexilate. front pharmacol. 2013 feb 12;4:12.

Dabigatran Preparation Products And Raw materials

Raw materials

Preparation Products

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Dabigatran Suppliers

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View Lastest Price from Dabigatran manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Dabigatran 211914-51-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-19
Henan Fengda Chemical Co., Ltd
Product
Dabigatran 211914-51-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
dabigatran 211914-51-1
Price
US $1.21/IU
Min. Order
100g
Purity
99%
Supply Ability
30kgs
Release date
2021-12-09

211914-51-1, DabigatranRelated Search:

Rivaroxaban Dabigatran etexilate Dabigatran Etexilate Mesylate 4-methoxy-N-methyl-3-nitrobenzamide 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester N-(4-CYANO-PHENYL)-GLYCINE Chloroacetic anhydride 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Bortezomib Y27632 (hydrochloride) (+)-JQ1 Apixaban Dabigatran iMpurity K Dabigatran iMpurity D Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

  • 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Met
  • BIBR 953(Dabigatran)
  • N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benzo[d]iMidazol-5-yl]carbonyl]-N-pyridin-2-yl-beta-alanine
  • N-[(2-{[(4-carbaMiMidoylphenyl)aMino]Methyl}-1-Methyl-1HbenziMidazol- 5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine
  • BIBR 953 (Dabigatran, Pradaxa)
  • 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Methyl-benzoiMidazole-5-carbonyl]-pyridin-2-yl-aMino]
  • BIB-953
  • BIBR 953ZW
  • Dabigatran (BIBR 953)
  • N- (2-{ (4-carbaMiMidoylphenyl)aMino Methyl}-1-Met
  • BIBR 953
  • Dabigatran Impurity U
  • Dabigatran etexilate-1
  • BIBR953;BIBR 953;BIBR-953
  • CS-1864
  • Dabigatran(BIB-953
  • BIBR 953;BIBR 953ZW;BIBR953;BIB-953
  • β-Alanine,N-[[2-[[[4-(aMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-
  • 3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
  • 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid Dabigatran (BIBR 953)
  • Dabigatran Impurity b
  • Dabigatran (Acid)
  • 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic
  • Dabigatran3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
  • 3-[[2-[[(4-carbamimidoylphenyl)amino]methyl]-1-methyl-benzoimidazole-5-carbonyl]-pyridin-2-yl-amino]propanoic acid
  • 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
  • ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
  • Dabigatran Etexilate Mesilate
  • Dabigatran
  • Dabigatran Ester Impurity B
  • b-Alanine,N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
  • N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine
  • Dabigatran USP/EP/BP
  • Dabigatran base
  • Dabiga group
  • N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-ben...
  • Dabigatran etexilate impurity189
  • Dabigatran etexilate impurity1513
  • DabigatranQ: What is Dabigatran Q: What is the CAS Number of Dabigatran Q: What is the storage condition of Dabigatran Q: What are the applications of Dabigatran
  • Dabigatran API
  • Dabigatran Standard
  • Dabigatran AKSci B955
  • 3-[2-[[(4-Carbamimidoylphenyl)amino]methyl]-1-methyl-N-(2-pyridyl)benzimidazole-5-carboxamido]propanoic Acid
  • Desethyl Dabigatran Etexilate Impurity D
  • 211914-51-1
  • C25H25N7O3
  • Inhibitor
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • benzimidazol
  • Dabigatran impurity
  • Aromatics
  • Bases & Related Reagents
  • Heterocycles
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