Dabigatran

Product Name: Dabigatran
CAS No.: 211914-51-1
Chemical Name: Dabigatran
Synonyms: BIB-953;CS-1864;BIBR 953;BIBR 953ZW;Dabigatran;Dabiga group;Dabigatran API;Dabigatran base;Dabigatran (Acid);Dabigatran(BIB-953
CBNumber: CB61458206
Molecular Formula: C25H25N7O3
Formula Weight: 471.51
MOL File: 211914-51-1.mol

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Dabigatran Property

Melting point:: 268-272°C
Boiling point:: 797.1±70.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Aqueous Acid
form: Solid
pka: 4.17±0.10(Predicted)
color: White to Brown

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Safety

Hazardous Substances Data: 211914-51-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17133
Product name: Dabigatran
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17133
Product name: Dabigatran
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 17133
Product name: Dabigatran
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 17133
Product name: Dabigatran
Purity: ≥95%
Packaging: 50mg
Price: $606
Updated: 2024/03/01

TRC

Product number: D100090
Product name: Dabigatran
Packaging: 50mg
Price: $525
Updated: 2021/12/16

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Dabigatran Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

BIBR 953 (Dabigatran, Pradaxa) is potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-b ta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.

Biological Activity

bibr 953 is a potent, reversible, and direct inhibitor of thrombin with ic50 value of 9.3nm [1].bibr 953 shows a favorable selectivity profile and strong activity in vitro with a ki value of 4.5nm. it also exhibits the best activity profile in vivo following administration to rats. bibr 953 is designed to be converted into an orally active prodrug bibr 1048 due to its highly polar, zwitterionic nature and poor oral absorption. bibr 953 inhibits thrombin in a competitive fashion. this inhibition is rapid and reversible. bibr 953 inhibits both clot-bound and free thrombin. bibr 953 is demonstrated to have an anticoagulant efficacy both in vitro and ex vivo. since thrombin can affect cell behavior and response in various tissue types via par signaling, bibr 953 is found to be beneficial in many diseases including inflammation, infection, fibrosis and cancer.

target

thrombin

References

[1] hauel nh, nar h, priepke h, ries u, stassen jm, wienen w. structure-based design of novel potent nonpeptide thrombin inhibitors. j med chem. 2002 apr 25;45(9):1757-66.
[2] van ryn j, goss a, hauel n, wienen w, priepke h, nar h, clemens a. the discovery of dabigatran etexilate. front pharmacol. 2013 feb 12;4:12.

Dabigatran Preparation Products And Raw materials

Raw materials

Preparation Products

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Dabigatran Suppliers

Canada 1 China 234 Europe 1 India 28 Japan 1 United Kingdom 1 United States 19 Global 285

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23680
Advantage: 75

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View Lastest Price from Dabigatran manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Dabigatran 211914-51-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-19

Henan Fengda Chemical Co., Ltd

Product: Dabigatran 211914-51-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: dabigatran 211914-51-1
Price: US $1.21/IU
Min. Order: 100g
Purity: 99%
Supply Ability: 30kgs
Release date: 2021-12-09

211914-51-1, DabigatranRelated Search:

Rivaroxaban Dabigatran etexilate Dabigatran Etexilate Mesylate 4-methoxy-N-methyl-3-nitrobenzamide 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester N-(4-CYANO-PHENYL)-GLYCINE Chloroacetic anhydride 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Bortezomib Y27632 (hydrochloride) (+)-JQ1 Apixaban Dabigatran iMpurity K Dabigatran iMpurity D Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Met

BIBR 953(Dabigatran)

N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benzo[d]iMidazol-5-yl]carbonyl]-N-pyridin-2-yl-beta-alanine

N-[(2-{[(4-carbaMiMidoylphenyl)aMino]Methyl}-1-Methyl-1HbenziMidazol- 5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine

BIBR 953 (Dabigatran, Pradaxa)

3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Methyl-benzoiMidazole-5-carbonyl]-pyridin-2-yl-aMino]

BIB-953

BIBR 953ZW

Dabigatran (BIBR 953)

N- (2-{ (4-carbaMiMidoylphenyl)aMino Methyl}-1-Met

BIBR 953

Dabigatran Impurity U

Dabigatran etexilate-1

BIBR953;BIBR 953;BIBR-953

CS-1864

Dabigatran(BIB-953

BIBR 953;BIBR 953ZW;BIBR953;BIB-953

β-Alanine,N-[[2-[[[4-(aMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-

3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid

3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid Dabigatran (BIBR 953)

Dabigatran Impurity b

Dabigatran (Acid)

3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic

Dabigatran3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid

3-[[2-[[(4-carbamimidoylphenyl)amino]methyl]-1-methyl-benzoimidazole-5-carbonyl]-pyridin-2-yl-amino]propanoic acid

3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid

ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate

Dabigatran Etexilate Mesilate

Dabigatran

Dabigatran Ester Impurity B

b-Alanine,N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine

Dabigatran USP/EP/BP

Dabigatran base

Dabiga group

N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-ben...

Dabigatran etexilate impurity189

Dabigatran etexilate impurity1513

DabigatranQ: What is Dabigatran Q: What is the CAS Number of Dabigatran Q: What is the storage condition of Dabigatran Q: What are the applications of Dabigatran

Dabigatran API

Dabigatran Standard

Dabigatran AKSci B955

3-[2-[[(4-Carbamimidoylphenyl)amino]methyl]-1-methyl-N-(2-pyridyl)benzimidazole-5-carboxamido]propanoic Acid

Desethyl Dabigatran Etexilate Impurity D

211914-51-1

C25H25N7O3

Inhibitor

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

benzimidazol

Dabigatran impurity

Aromatics

Bases & Related Reagents

Heterocycles

Inhibitors

Other APIs