ChemicalBook > CAS DataBase List > 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Product Name
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
CAS No.
199666-03-0
Chemical Name
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Synonyms
CS-1828;R061-8048;Ro 61-8048, >=98%;Ro 61-8048 >=98% (HPLC);KMO Inhibitor I, Ro 61-8048;KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem;3,4-Dimethoxy-N-4-(3-nitro-phenyl)-thiazol-2-yl-benzenesulfomide;3,4-diMethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonaMide;3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide;Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-
CBNumber
CB61458468
Molecular Formula
C17H15N3O6S2
Formula Weight
421.45
MOL File
199666-03-0.mol
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3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Property

Melting point:
185℃
Boiling point:
627.4±65.0 °C(Predicted)
Density 
1.471±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
DMSO: ≥15mg/mL
pka
6.29±0.10(Predicted)
form 
Yellow solid
color 
faint yellow to yellow
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0233
Product name
Ro 61-8048
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
420360-M
Product name
KMO Inhibitor I, Ro 61-8048
Packaging
10mg-m
Price
$135
Updated
2021/12/16
Sigma-Aldrich
Product number
420360-M
Product name
KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
Packaging
10mg
Price
$135
Updated
2021/12/16
Cayman Chemical
Product number
15199
Product name
Ro 61-8048
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15199
Product name
Ro 61-8048
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
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3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Chemical Properties,Usage,Production

Uses

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.

Definition

ChEBI: Ro 61-8048 is a C-nitro compound.

Biological Activity

Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.

Biochem/physiol Actions

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.

storage

+4°C

3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Suppliers

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View Lastest Price from 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide manufacturers

Career Henan Chemical Co
Product
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide 199666-03-0
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98%
Supply Ability
10kg
Release date
2019-09-04

199666-03-0, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamideRelated Search:

(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide AZD6738 SGC707 MS023 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Enasidenib Epacadostat (INCB024360) indoleaMine-2,3-dioxygenase inhibitor INCB024360 LLY-507 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide DBeQ Ro 3306 Bisindoylmaleimide X RO495 3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)-N-(2-hydroxyethoxy)-5-((3-oxoMorpholino)Methyl)benzaMide ROC-325 RO2959 Hydrochloride

  • Ro 61-8048, >=98%
  • RO61-80483,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)Benzenesulfonamide
  • 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide RO61-8048
  • RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
  • KMO Inhibitor I, Ro 61-8048
  • 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
  • 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
  • 3,4-diMethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonaMide
  • CS-1828
  • KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
  • R061-8048
  • 3,4-Dimethoxy-N-4-(3-nitro-phenyl)-thiazol-2-yl-benzenesulfomide
  • Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-
  • Ro 61-8048 >=98% (HPLC)
  • NMDA,Ro 61 8048,inhibit,Ro 61-8048,dystonia,Inhibitor,hydroxylase,Ro 618048,kynurenine
  • 3,4-dimethoxy 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
  • 199666-03-0
  • C17H15N3O6S2
  • Inhibitors