ChemicalBook > CAS DataBase List > 3-BROMO-5-NITROBENZALDEHYDE
3-BROMO-5-NITROBENZALDEHYDE
- Product Name
- 3-BROMO-5-NITROBENZALDEHYDE
- CAS No.
- 355134-13-3
- Chemical Name
- 3-BROMO-5-NITROBENZALDEHYDE
- Synonyms
- 3-BROMO-5-NITROBENZALDEHYDE;3-Nitro-5-bromo-benzaldehyde;3-Bromo-5-formylnitrobenzene;3-Fluoro-5-nitrobenzaldehyde;Benzaldehyde,3-bromo-5-nitro-;3-Bromo-5-nitrobenzaldehyde 95%;3-BroMo-5-nitrobenzaldehyde, 97+%
- CBNumber
- CB61471016
- Molecular Formula
- C7H4BrNO3
- Formula Weight
- 230.02
- MOL File
- 355134-13-3.mol
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3-BROMO-5-NITROBENZALDEHYDE Property
- Melting point:
- 101-106 °C
- Boiling point:
- 306.9±27.0 °C(Predicted)
- Density
- 1.781
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Powder
- color
- Pale brown
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HS Code
- 2913000090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 702986
- Product name
- 3-Bromo-5-nitrobenzaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $69.5
- Updated
- 2023/01/07
Sigma-Aldrich
- Product number
- 702986
- Product name
- 3-Bromo-5-nitrobenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $125
- Updated
- 2023/01/07
TCI Chemical
- Product number
- B4982
- Product name
- 3-Bromo-5-nitrobenzaldehyde
- Packaging
- 1G
- Price
- $73
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B4982
- Product name
- 3-Bromo-5-nitrobenzaldehyde
- Packaging
- 5G
- Price
- $219
- Updated
- 2025/07/31
TRC
- Product number
- B699445
- Product name
- 3-Bromo-5-nitrobenzaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
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3-BROMO-5-NITROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Fluoro-5-nitrobenzaldehyde is used as a reactant in the design and synthesis of selective activators of cardiac myosin.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 5867, 2007 DOI: 10.1021/jo070477u
Synthesis
99-61-6
355134-13-3
General procedure for the synthesis of 3-bromo-5-nitrobenzaldehyde from m-nitrobenzaldehyde: 3-nitrobenzaldehyde (1.0 g, 6.6 mmol) was dissolved in concentrated sulfuric acid (4.0 mL) at room temperature, followed by batchwise addition of N-bromosuccinimide (1.4 g, 7.9 mmol). The reaction mixture was heated to 65 °C and maintained at this temperature for 1 hour. After completion of the reaction, it was cooled to room temperature and the reaction solution was slowly poured into ice water, the solid was precipitated and collected by filtration. The crude product was dried with anhydrous sodium sulfate and purified by recrystallization through a solvent mixture of ethyl acetate/petroleum ether (1:10, v/v) to finally obtain 3-bromo-5-nitrobenzaldehyde (1.3 g, 82% yield) as white crystals. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 10.09 (s, 1H), 8.79-8.55 (m, 2H), 8.51 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 12, p. 5235 - 5244
[2] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5867 - 5869
[3] European Journal of Medicinal Chemistry, 2016, vol. 116, p. 46 - 58
[4] Journal of the American Chemical Society, 2007, vol. 129, # 15, p. 4512 - 4513
[5] Patent: WO2009/153313, 2009, A1. Location in patent: Page/Page column 185
3-BROMO-5-NITROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-NITROBENZALDEHYDE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 3-Bromo-5-nitrobenzaldehyde 355134-13-3
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-08
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3-BROMO-5-NITROBENZALDEHYDE 355134-13-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
Career Henan Chemical Co
- Product
- 3-BROMO-5-NITROBENZALDEHYDE 355134-13-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25
355134-13-3, 3-BROMO-5-NITROBENZALDEHYDERelated Search:
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