ChemicalBook > CAS DataBase List > Ethyl cellulose

Ethyl cellulose

Product Name
Ethyl cellulose
CAS No.
9004-57-3
Chemical Name
Ethyl cellulose
Synonyms
ets;g50;t100;g200;ethocel;spt50cps;nixone/c;aquacoat;ethocele7;ethoceln7
CBNumber
CB6165620
Molecular Formula
C23H24N6O4
Formula Weight
448.47446
MOL File
9004-57-3.mol
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Ethyl cellulose Property

Melting point:
240-255 °C
Density 
1.14 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.47(lit.)
storage temp. 
2-8°C
solubility 
esters, aromatic hydrocarbons, alcohols and ketones: soluble
form 
powder
color 
White to slightly yellow
Specific Gravity
1.14
Water Solubility 
insoluble
Merck 
14,3781
EPA Substance Registry System
Ethyl cellulose (9004-57-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
FJ5950500
3
Autoignition Temperature
698 °F
TSCA 
Yes
HS Code 
39129000
Hazardous Substances Data
9004-57-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46080
Product name
Ethyl cellulose
Purity
48.0-49.5% (w/w) ethoxyl basis
Packaging
250 g
Price
$116
Updated
2021/03/22
Sigma-Aldrich
Product number
200646
Product name
Ethyl cellulose
Purity
viscosity 4 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Packaging
250g
Price
$155
Updated
2020/08/18
Sigma-Aldrich
Product number
Y0001633
Product name
Ethyl cellulose
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
46070
Product name
Ethyl cellulose
Purity
48.0-49.5% (w/w) ethoxyl basis
Packaging
250 g
Price
$182
Updated
2021/03/22
Sigma-Aldrich
Product number
46070
Product name
Ethyl cellulose
Purity
48.0-49.5% (w/w) ethoxyl basis
Packaging
1 kg
Price
$373
Updated
2021/03/22
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Ethyl cellulose Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellowish powder

Chemical Properties

Ethylcellulose is a tasteless, free-flowing, white to light tan-colored powder.

Uses

ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose.

Uses

Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates.

Uses

In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder).

Uses

Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit.

Production Methods

Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical:
RONa + C2H5Cl→ROC2H5+NaCl
The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three.

Preparation

Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl.
Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures.

brand name

Aquacoat ECD (FMC);Ethocel (Dow Chemical).

Pharmaceutical Applications

Ethylcellulose is widely used in oral and topical pharmaceutical formulations.
The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former.
Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression.
High-viscosity grades of ethylcellulose are used in drug microencapsulation.
Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area.
In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution.
Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances.
In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions.
Ethylcellulose is additionally used in cosmetics and food products.

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys.
Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material.
As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg

storage

Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters.
Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range.
Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents.

Incompatibilities

Incompatible with paraffin wax and microcrystalline wax.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethyl cellulose Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl cellulose Suppliers

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View Lastest Price from Ethyl cellulose manufacturers

Hebei Crovell Biotech Co Ltd
Product
Ethyl cellulose 9004-57-3
Price
US $40.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2021-06-29
Shijiazhuang tongyang Import and Export Co., LTD
Product
Ethyl cellulose 9004-57-3
Price
US $10.00/KG
Min. Order
1g
Purity
99
Supply Ability
100kg/kg
Release date
2021-08-11
Hebei Yanxi Chemical Co., Ltd.
Product
Ethyl cellulose;EC 9004-57-3
Price
US $2.80/Kg/Bag
Min. Order
1T
Purity
99%
Supply Ability
900tons/month
Release date
2020-07-13

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