4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE

Product Name: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE
CAS No.: 94741-69-2
Chemical Name: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE
Synonyms: BUTTPARK 60\40-60;4-amino-2-chloropyrimidine-5-nitrile;4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR&;4-AMINO-2-CHLORO-5-PYRIMIDINECARBONITRILE;4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE;5-PyriMidinecarbonitrile, 4-aMino-2-chloro-;4-Amino-2-chloropyrimidine-5-carbonitrile ,97%;4-Amino-2-chloropyrimidine-5-carbonitrile , Tech.
CBNumber: CB6175946
Molecular Formula: C5H3ClN4
Formula Weight: 154.56
MOL File: 94741-69-2.mol

More

Less

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE Property

Melting point:: 200 °C (dec.) (lit.)
Boiling point:: 435.0±30.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMF, DMSO, Methanol, Water
pka: -0.68±0.10(Predicted)
form: Powder or Flakes
color: Brown
InChI: InChI=1S/C5H3ClN4/c6-5-9-2-3(1-7)4(8)10-5/h2H,(H2,8,9,10)
InChIKey: WDHFCSOENXEMRC-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C#N)C(N)=N1
CAS DataBase Reference: 94741-69-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41-43
Safety Statements: 26-36/37/39
RIDADR: UN3439
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 597600
Product name: 4-Amino-2-chloropyrimidine-5-carbonitrile
Purity: 97%
Packaging: 1g
Price: $102
Updated: 2023/01/07

TRC

Product number: A604030
Product name: 4-Amino-2-chloropyrimidine-5-carbonitrile
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0022766
Product name: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE
Purity: 95.00%
Packaging: 1G
Price: $166.95
Updated: 2021/12/16

Matrix Scientific

Product number: 044959
Product name: 4-Amino-2-chloro-5-pyrimidinecarbonitrile
Purity: >95%
Packaging: 500mg
Price: $244
Updated: 2021/12/16

Matrix Scientific

Product number: 044959
Product name: 4-Amino-2-chloro-5-pyrimidinecarbonitrile
Purity: >95%
Packaging: 1g
Price: $304
Updated: 2021/12/16

More

Less

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

White to yellow to brown solid

Uses

4-Amino-2-chloropyrimidine-5-carbonitrile is a potential substituent in the synthesis of anti-anxiety, anti-depressant and anti-psychotic agents.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1305, 1987 DOI: 10.1002/jhet.5570240514

Synthesis

3177-24-0

1393179-35-5

94741-69-2

2,4-Dichloropyrimidine-5-carbonitrile (E-1) (2.0 g, 11.5 mmol) was used as a feedstock and dissolved in 1,4-dioxane (20 mL) at 0 °C. Subsequently, ammonium hydroxide solution (28-30%, 4.4 mL, 34.5 mmol) was slowly added dropwise and the reaction mixture was kept at 0 °C during the dropwise addition. After the dropwise addition was completed, the reaction mixture was gradually warmed from 0 °C to room temperature with continuous stirring for 2 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and partitioned with ethyl acetate (200 mL) and water (50 mL). The organic layer was separated and washed with brine and subsequently dried over anhydrous sodium sulfate. The dried organic phase was filtered, mixed with silica gel and concentrated under vacuum. The residue was purified by silica gel column chromatography using a 0-100% ethyl acetate/hexane gradient elution to afford the target product 2-amino-4-chloropyrimidine-5-carbonitrile (E-2) (917 mg) and a mixture of (E-2) and 4-amino-2-chloropyrimidine-5-carbonitrile (E-3). Further purification by a second column chromatography allowed the isolation of additional (E-3) from the above mixture.

References

[1] Patent: US2013/53362, 2013, A1. Location in patent: Paragraph 0723; 0724; 0725
[2] Patent: WO2015/168079, 2015, A1. Location in patent: Paragraph 00607; 00608

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Ethanol Sodium Chloroform Hydrochloric acid Methanol Magnesium Cyanamide Ethoxymethylenemalononitrile

Preparation Products

More

Less

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE Suppliers

Belgium 1 China 115 Germany 5 India 7 Switzerland 2 United Kingdom 15 United States 29 Global 174

Key Organics Ltd.

Tel: --
Fax: --
Email: enquiries@keyorganics.net
Country: United Kingdom
ProdList: 851
Advantage: 58

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Biosynth Carbosynth

Tel: --
Fax: --
Email: ales@carbosynth.com
Country: United Kingdom
ProdList: 2598
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Key Organics Limited/Bionet Research

Tel: --
Fax: --
Email: enquiries@keyorganics.ltd.uk
Country: United Kingdom
ProdList: 6663
Advantage: 50

Molekula Ltd

Tel: --
Fax: --
Email: info@molekula.com
Country: United Kingdom
ProdList: 4060
Advantage: 50

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Butt Park Ltd.

Tel: --
Fax: --
Email: 113707.50@compuserve.com
Country: United Kingdom
ProdList: 6078
Advantage: 30

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-amino-2-chloropyrimidine-5-carbonitrile 94741-69-2
Price: US $3.00-9.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 50kg
Release date: 2025-07-28

Henan Aochuang Chemical Co.,Ltd.

Product: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE 94741-69-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMino-2-chloro-5-pyriMidinecarbonitrile 94741-69-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

94741-69-2, 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILERelated Search:

4-Amino-2-chloropyrimidine 2-Chloropyrimidine 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 3-Amino-6-chloropyridine-2-carbonitrile 4-Cyanocinnamic acid 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE AURORA KA-6205 4-Pyrimidinamine, 5-methyl- (9CI) 5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI) 4-Amino-2-chloro-5-methylpyrimidine 2-Chloro-5-methylpyrimidine 5-CYANOPYRIMIDINE 4-AMINOPYRIMIDINE-5-CARBONITRILE

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE

4-AMINO-2-CHLORO-5-PYRIMIDINECARBONITRILE

BUTTPARK 60\40-60

4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR&

4-Amino-2-chloropyrimidine-5-carbonitrile , Tech.

4-Amino-2-chloropyrimidine-5-carbonitrile ,97%

5-PyriMidinecarbonitrile, 4-aMino-2-chloro-

4-amino-2-chloropyrimidine-5-nitrile

94741-69-2

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

Heterocycle-Pyrimidine series

Building Blocks

C4 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Pyrimidine

Heterocyclic Compounds