(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol

Uses

Product Name: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
CAS No.: 14347-78-5
Chemical Name: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Synonyms: (R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL;(R)-(-)-SOLKETAL;R-Glycerol;ane-4-methanoL;R-(-)-Sollketal;(R)-(-) -acetone;R-GLYCEROL ACETONIDE;L-Glycerol-acetonide;(R)-(-)-2,2-Dimethyl-1;Glycerol Formal Impurity 8
CBNumber: CB6184467
Molecular Formula: C6H12O3
Formula Weight: 132.16
MOL File: 14347-78-5.mol

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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Property

alpha: -13.7 º (neat)
Boiling point:: 72-73 °C/8 mmHg (lit.)
Density: 1.062 g/mL at 25 °C (lit.)
refractive index: n20/D 1.434
Flash point:: 176 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
pka: 14.20±0.10(Predicted)
color: Clear colorless to light yellow
Specific Gravity: 1.062
optical activity: [α]20/D 13.7°, neat
Water Solubility: miscible
Merck: 14,5213
BRN: 80117
Stability:: Stable. Incompatible with strong oxidizing agents.
InChI: 1S/C6H12O3/c1-6(2)8-4-5(3-7)9-6/h5,7H,3-4H2,1-2H3/t5-/m1/s1
InChIKey: RNVYQYLELCKWAN-RXMQYKEDSA-N
SMILES: CC1(C)OC[C@@H](CO)O1
CAS DataBase Reference: 14347-78-5(CAS DataBase Reference)
NIST Chemistry Reference: D-Acetone glycerol(14347-78-5)

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Safety

Safety Statements: 23-24/25
WGK Germany: 3
RTECS: JI0400000
F: 10
HS Code: 29329990
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 241806
Product name: (R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity: 98%
Packaging: 1g
Price: $36.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 241806
Product name: (R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity: 98%
Packaging: 5g
Price: $75.9
Updated: 2025/07/31

TCI Chemical

Product number: D1705
Product name: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity: >97.0%(GC)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: D1705
Product name: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity: >97.0%(GC)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: D1705
Product name: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity: >97.0%(GC)
Packaging: 25g
Price: $137
Updated: 2025/07/31

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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Chemical Properties,Usage,Production

Uses

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol is a MEK inhibitor with antitumor activity.

Chemical Properties

colourless liquid

Uses

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol may be used to prepare:

(R)-2,2-Dimethyl-4-benzoxymethyl-1,3-dioxolane.
((S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate)-1,3-dioxolane.
(S)-Glyceraldehyde acetonide.
Tetraoxaspiroundecanes, diglycerides, glyceryl phosphates, and spiropyrans.

Uses

A MEK inhibitor

Synthesis

Using anhydrous zinc chloride as the catalyst, the condensation reaction of D-mannitol with acetone to synthesize the diisopropylidene condensate was carried out under the optimal reaction conditions, with a yield of up to 65%. Subsequently, (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol was obtained via chain cleavage by NaIO₄ oxidation and reduction with NaBH₄.

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Preparation Products And Raw materials

Raw materials

L(+)-Diethyl L-tartrate p-Toluenesulfonic acid Ethanol 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Acetone Tetrabutylammonium bromide Sodium borohydride Tetrahydrofuran (2S,3S)(-)-Dihydroxybutane-1,4-dioic acid diethyl ester Ethyl acetate Acetic acid Sodium periodate

Preparation Products

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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Suppliers

Americas 1 Austria 1 Belgium 4 Canada 2 China 271 China Hong Kong 1 Europe 2 France 2 Germany 9 India 12 Ireland 1 Japan 7 Slovakia 2 South Korea 2 Switzerland 8 The Netherlands 1 United Kingdom 15 United States 47 Global 388

Suzhou Highfine Biotech Co., Ltd

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J & K SCIENTIFIC LTD.

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View Lastest Price from (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 14347-78-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-(-)-Solketal 14347-78-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R) - (-) -2, 2-Dimethyl-1, 3-Dioxolane-4-Methanol 14347-78-5
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

14347-78-5, (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanolRelated Search:

Hydroxyacetone Glycerol Dimethyl ether Dimethyl carbonate Dimethyl fumarate Dacthal Methanol Dimethyl sulfoxide 1,3-Dioxan-5-ol N,N-Dimethylformamide Dimethyl disulfide Diacetone Alcohol Dimethyl sulfate ETHANE Nitroglycerin Diacetonefructose 2,2-Dimethyl-1,3-dioxolane-4-methanol 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE

L-ALPHA,BETA-ISOPROPYLIDENEGLYCEROL

L-2,3-O-ISOPROPYLIDENE-SN-GLYCEROL

L-(-)-1,2-ISOPROPYLIDENEGLYCEROL

2,3-ISOPROPYLIDENE-SN-GLYCEROL

2,3-O-ISOPROPYLIDENE-L-GLYCEROL

(-)-2,3-O-ISOPROPYLIDENE-SN-GLYCEROL

R-GLYCEROL ACETONIDE

R-(-)-2,3-O-ISOPROPYLIDENEGLYCEROL

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, 95+%

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, L-α,β-Isopropylideneglycerol

2,3-Isopropylidene-sn-glycerol, L-α,β-Isopropylideneglycerol, L-2,3-O-isopropylidene-sn-glycerol

(2R)-1-O,2-O-Isopropylideneglycerol

(4R)-2,2-Dimethyl-1,3-dioxolane-4α-methanol

(4R)-2,2-Dimethyl-4-hydroxymethyl-1,3-dioxolane

(-)-2,3-O-ISOPROPYLIDENE-SN-GLYCE

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol,98%

R-(-)-Sollketal

(R)-(-)-2,2-Dimethyl-1,3-dioxlane-4-methanol

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98%

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol (R)-(-)-Sollketal

(R)-2,3-ISOPROPYLIDENE GLYCEROL

R-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-METHANOL

((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANOL

R-(-)-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANOL

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL

(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL

(R)-(-)-2,2-DIMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE

(R)-2,2-DIMETHYL 4-HYDROXYMETHYL-1,3-DIOXOLANE

(R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL

(R)-(-)-SOLKETAL

(R)-2,2-dimethyl-1,3-dioxalone-4-methanol

L-Glycerol-acetonide

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-MET HANOL, 98% (99% EE/GLC)

(R)-(-)-1,2-Isopropylideneglycerol

Glycerol acetonide((R)-1,2-O-Isopropylideneglycerol)

R-Glycerol

1,3-Dioxolane-4-methanol, 2,2-dimethyl-, (4R)-

(R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL (GLYCEROL ACETONIDE)

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL ((R)-(-)-SOLKETAL)

L-a,b-Isopropylideneglycerol

SOLKETAL A.K.A. (R)-O-ISOPROPYLIDENE GLYCEROL

ISOPROPYLIDENEGLYCEROL 23RO

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL 97+%

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol (-)-2,3-O-Isopropylidene-sn-glycerol

[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol

ane-4-methanoL

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, 98%, ee: 98%

(R)-(-)-1,2-O-Isopropylideneglycerol 97%

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol&gt

(R) - (-) - Glycerol Acetone

(R)-(-)-2,2-Dimethyl-1

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 2,3-Isopropylidene-sn-glycerol

L-α,β-Isopropylideneglycerol

R-(-)-Glycerol Acetone Acetal

(R)-2,2-Dimethyl-1,3-dioxolane-4-methanol / (R)-1,2-Isopropylideneglycerol

R-(-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methnaol

(R)-(-) -acetone

Glycerol Formal Impurity 8