3-METHYL-PYRIDINE-4-CARBOXAMIDE

Product Name: 3-METHYL-PYRIDINE-4-CARBOXAMIDE
CAS No.: 251101-36-7
Chemical Name: 3-METHYL-PYRIDINE-4-CARBOXAMIDE
Synonyms: 3-Methylisonicotinamide;3-METHYL-PYRIDINE-4-CARBOXAMIDE;4-Pyridinecarboxamide, 3-methyl-;4-Pyridinecarboxamide,3-methyl-(9CI);2-carbaMoyl-3-Methylpyridine-4-carboxylic acid
CBNumber: CB6185419
Molecular Formula: C7H8N2O
Formula Weight: 136.15
MOL File: 251101-36-7.mol

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3-METHYL-PYRIDINE-4-CARBOXAMIDE Property

Boiling point:: 290.8±28.0 °C(Predicted)
Density: 1.157±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.98±0.50(Predicted)
InChI: InChI=1S/C7H8N2O/c1-5-4-9-3-2-6(5)7(8)10/h2-4H,1H3,(H2,8,10)
InChIKey: QMDMUIQZTHZWGH-UHFFFAOYSA-N
SMILES: C1=NC=CC(C(N)=O)=C1C

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR950771
Product name: 3-Methylisonicotinamide
Purity: 95%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 4356CH
Product name: 3-Methylisonicotinamide
Packaging: 1g
Price: $327
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010786
Product name: 3-METHYL-PYRIDINE-4-CARBOXAMIDE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Ambeed

Product number: A583278
Product name: 3-Methylisonicotinamide
Purity: 97%
Packaging: 100mg
Price: $59
Updated: 2021/12/16

Ambeed

Product number: A583278
Product name: 3-Methylisonicotinamide
Purity: 97%
Packaging: 250mg
Price: $86
Updated: 2021/12/16

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3-METHYL-PYRIDINE-4-CARBOXAMIDE Chemical Properties,Usage,Production

Synthesis

4021-12-9

251101-36-7

General procedure for the synthesis of 3-methylpyridine-4-carboxamide from 3-methyl-4-pyridinecarboxylic acid: 3-methyl-4-pyridinecarboxylic acid (0.5 g, 3.6 mmol) was dissolved in thionyl chloride (3 mL) and heated to reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed by evaporation under reduced pressure. The resulting chloride solid was added to ammonium hydroxide solution (30 mL, 25% aqueous solution) in batches under ice bath conditions. Subsequently, the reaction mixture was slowly warmed to room temperature and stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: methanol/dichloromethane, 40:1) to give a white solid product in 63% yield. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 8.50-8.48 (m, 1H), 8.46-8.44 (m, 1H), 7.42 (d, J = 5.0 Hz, 1H), 2.45 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 12, p. 3559 - 3572
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[3] Patent: US2014/18360, 2014, A1
[4] Chemistry - A European Journal, 2016, vol. 22, # 24, p. 8301 - 8308

3-METHYL-PYRIDINE-4-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-METHYL-PYRIDINE-4-CARBOXAMIDE Suppliers

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251101-36-7, 3-METHYL-PYRIDINE-4-CARBOXAMIDERelated Search:

3,4-PYRIDINEDICARBOXIMIDE Sorafenib 3-Methylpicolinamide 4-Methyl-3-pyridinecarboxamide 2-Carboxamide-6-(hydroxymethyl)pyridine N-Methyl-4-chloropyridine-2-carboxamide 2-Hydroxy-6-(trifluoromethyl)nicotinamide 5-METHYLNICOTINAMIDE 4-(Trifluoromethyl)pyridine-3-carboxamide oxime 4-Chloro-N-methylpyridine-2-carboxamide Hydrochloride 4-carbamoylpyridine-3-carboxylate 4-Chloro-6-methyl-2-(4-methylbenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 4-CHLORO-6-METHYL-2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE-1,3-DIONE 4-Chloro-6-methyl-2-[3-(trifluoromethyl)Benzyl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 1,2,3,4-TETRAHYDRO-ACRIDINE-9-CARBOXYLIC ACID AMIDE 4-chloro-2-(2-chloro-6-fluoroBenzyl)-6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione 3,4-PYRIDINEDICARBOXAMIDE SB 222200

3-METHYL-PYRIDINE-4-CARBOXAMIDE

2-carbaMoyl-3-Methylpyridine-4-carboxylic acid

4-Pyridinecarboxamide,3-methyl-(9CI)

3-Methylisonicotinamide

4-Pyridinecarboxamide, 3-methyl-

251101-36-7

Pyridines

PYRIDINE

AMIDE