3-METHYL-PYRIDINE-4-CARBOXAMIDE
- Product Name
- 3-METHYL-PYRIDINE-4-CARBOXAMIDE
- CAS No.
- 251101-36-7
- Chemical Name
- 3-METHYL-PYRIDINE-4-CARBOXAMIDE
- Synonyms
- 3-Methylisonicotinamide;3-METHYL-PYRIDINE-4-CARBOXAMIDE;4-Pyridinecarboxamide, 3-methyl-;4-Pyridinecarboxamide,3-methyl-(9CI);2-carbaMoyl-3-Methylpyridine-4-carboxylic acid
- CBNumber
- CB6185419
- Molecular Formula
- C7H8N2O
- Formula Weight
- 136.15
- MOL File
- 251101-36-7.mol
3-METHYL-PYRIDINE-4-CARBOXAMIDE Property
- Boiling point:
- 290.8±28.0 °C(Predicted)
- Density
- 1.157±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.98±0.50(Predicted)
- InChI
- InChI=1S/C7H8N2O/c1-5-4-9-3-2-6(5)7(8)10/h2-4H,1H3,(H2,8,10)
- InChIKey
- QMDMUIQZTHZWGH-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(C(N)=O)=C1C
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR950771
- Product name
- 3-Methylisonicotinamide
- Purity
- 95%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 4356CH
- Product name
- 3-Methylisonicotinamide
- Packaging
- 1g
- Price
- $327
- Updated
- 2021/12/16
- Product number
- CHM0010786
- Product name
- 3-METHYL-PYRIDINE-4-CARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- A583278
- Product name
- 3-Methylisonicotinamide
- Purity
- 97%
- Packaging
- 100mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- A583278
- Product name
- 3-Methylisonicotinamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $86
- Updated
- 2021/12/16
3-METHYL-PYRIDINE-4-CARBOXAMIDE Chemical Properties,Usage,Production
Synthesis
4021-12-9
251101-36-7
General procedure for the synthesis of 3-methylpyridine-4-carboxamide from 3-methyl-4-pyridinecarboxylic acid: 3-methyl-4-pyridinecarboxylic acid (0.5 g, 3.6 mmol) was dissolved in thionyl chloride (3 mL) and heated to reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed by evaporation under reduced pressure. The resulting chloride solid was added to ammonium hydroxide solution (30 mL, 25% aqueous solution) in batches under ice bath conditions. Subsequently, the reaction mixture was slowly warmed to room temperature and stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: methanol/dichloromethane, 40:1) to give a white solid product in 63% yield. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 8.50-8.48 (m, 1H), 8.46-8.44 (m, 1H), 7.42 (d, J = 5.0 Hz, 1H), 2.45 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 12, p. 3559 - 3572
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[3] Patent: US2014/18360, 2014, A1
[4] Chemistry - A European Journal, 2016, vol. 22, # 24, p. 8301 - 8308
3-METHYL-PYRIDINE-4-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-METHYL-PYRIDINE-4-CARBOXAMIDE Suppliers
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