D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
- Product Name
- D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
- CAS No.
- 114676-59-4
- Chemical Name
- D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
- Synonyms
- Cis-D-Hyp-OMe.HC;Cis-D-Hyp-OMe.HCl;D-Proline, 4-Hydroxy;Cis-4-Hydroxy-D-proline Methyl ester HCl;(4R)-4-Hydroxy-D-proline methyl ester HCl;Methyl cis-4-Hydroxy-D-proline Hydrochloride;Methyl 4-hydroxypyrrolidine-2-carboxylate HCl;D-Proline, 4-hydroxy-, methyl ester (hydrochloride);Cis-4-hydroxy-proline Methyl ester hydrochloride -D-;D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1
- CBNumber
- CB61872286
- Molecular Formula
- C6H11NO3.ClH
- Formula Weight
- 181.618
- MOL File
- 114676-59-4.mol
D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Property
- Melting point:
- 121-123℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White
- optical activity
- 10.30(C=1.00g/100ml MEOH)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M323390
- Product name
- (2R,4R)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Z3901
- Product name
- (2R,4R)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- OR17883
- Product name
- Methyl(2R,4R)-4-hydroxypyrrolidine-2-carboxylatehydrochloride
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H29-5-X1
- Product name
- Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
- Packaging
- 1g
- Price
- $23
- Updated
- 2021/12/16
- Product number
- CS-M0680
- Product name
- (2R,4R)-methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
- Packaging
- 25g
- Price
- $112
- Updated
- 2021/12/16
D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Chemical Properties,Usage,Production
Uses
D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
Synthesis
67-56-1
2584-71-6
114676-59-4
To a stirred solution of cis-4-hydroxy-D-proline (10.0 g, 76.3 mmol, 1 eq.) in methanol (300 mL) was slowly added thionyl chloride (10.0 mL, excess) over 1.5 min at 0 °C. The reaction mixture was gradually warmed to 23 °C and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride as a white solid (15.9 g, 100% yield).
IC 50
Non-cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Preparation Products And Raw materials
Raw materials
Preparation Products
D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- manufacturers
- Product
- D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- 114676-59-4
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-01
- Product
- D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- 114676-59-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07