2-(Trifluormethoxy)phenylboronic acid

Product Name: 2-(Trifluormethoxy)phenylboronic acid
CAS No.: 175676-65-0
Chemical Name: 2-(Trifluormethoxy)phenylboronic acid
Synonyms: AKOS BRN-0449;RARECHEM AH PB 0077;2-(Trifluoromethoxy)Phenylboro;2-(Trifluoromethoxy)phenylboronic;TrifluoroMethoxy)phenylboronic ac;2-(Trifluormethoxy)phenylboronicaci;2-(TRIFLUORMETHOXY)PHENYLBORONIC ACID;2-(TrifluoroMethxoy)phenylboronic acid;O-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;2-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
CBNumber: CB6191126
Molecular Formula: C7H6BF3O3
Formula Weight: 205.93
MOL File: 175676-65-0.mol

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2-(Trifluormethoxy)phenylboronic acid Property

Melting point:: 118-120°C
Boiling point:: 267.2±50.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
Flash point:: 110℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Powder or Crystalline Powder
pka: 8.14±0.53(Predicted)
color: White to pale brown
BRN: 8766167
InChIKey: AIJCNTOYZPKURP-UHFFFAOYSA-N
CAS DataBase Reference: 175676-65-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22-22
Safety Statements: 26-36/37/39-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: MOISTURE SENSITIVE, KEEP COLD
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 683787
Product name: 2-(Trifluoromethoxy)phenylboronic acid
Packaging: 1g
Price: $33.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 683787
Product name: 2-(Trifluoromethoxy)phenylboronic acid
Packaging: 5g
Price: $76.4
Updated: 2023/06/20

TCI Chemical

Product number: T2413
Product name: 2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: T2413
Product name: 2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $53
Updated: 2025/07/31

TRC

Product number: T790855
Product name: 2-(Trifluoromethoxy)phenylboronic acid
Packaging: 100g
Price: $1090
Updated: 2021/12/16

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2-(Trifluormethoxy)phenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

2-(Trifluoromethoxy)phenylboronic Acid is a reagent that is used for the preparation of ERβ receptor that is selective towards 4-hydroxybiphenyls.

Uses

suzuki reaction

General Description

May contain varying amounts of anhydride.

Synthesis

64115-88-4

175676-65-0

The general procedure for the synthesis of 2-(trifluoromethoxy)phenylboronic acid from 1-bromo-2-(trifluoromethoxy)benzene was as follows: n-butyllithium (5.9 mL, 9.5 mmol) was slowly added dropwise to a solution of 1-bromo-2-(trifluoromethoxy)benzene (2 g, 8.2 mmol) in tetrahydrofuran (28 mL) at -78 °C and the reaction was stirred for 45 min. Subsequently, triisopropyl borate (2.58 mL, 11.1 mmol) was slowly added dropwise to the reaction mixture and the reaction system was slowly warmed to room temperature over 16 hours. Upon completion of the reaction, the reaction was quenched with water, the pH was adjusted to alkaline with 2 N NaOH solution and subsequently extracted with ethyl acetate. The aqueous phase was acidified to pH acidic with 2 N HCl solution, stirred for 1 h at room temperature and again extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the target product 2-(trifluoromethoxy)phenylboronic acid (1.10 g, 65% yield) as a white solid. The product was confirmed by NMR hydrogen spectroscopy (CDCl3): δ 7.96 (dd, J = 7.2, 1.6 Hz, 1H), 7.53 (ddd, J = 9.1, 7.3, 1.8 Hz, 1H), 7.38 (td, J = 7.3, 0.7 Hz, 1H), 7.28 (d, J = 8.2 Hz, 1H), 5.25 (br s, 2H). Mass spectrometry analysis showed the molecular ion peak m/e 206.9 (M + 1)+.

References

[1] Patent: WO2004/92140, 2004, A1. Location in patent: Page 38
[2] Patent: WO2005/97136, 2005, A1. Location in patent: Page/Page column 30

2-(Trifluormethoxy)phenylboronic acid Preparation Products And Raw materials

Raw materials

Nitrogen 2-(Trifluoromethoxy)bromobenzene Tetrahydrofuran Triisopropyl borate n-Butyllithium

Preparation Products

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2-(Trifluormethoxy)phenylboronic acid Suppliers

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View Lastest Price from 2-(Trifluormethoxy)phenylboronic acid manufacturers

Career Henan Chemical Co

Product: 2-(Trifluormethoxy)phenylboronic acid 175676-65-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg; 5kg; 100kg
Release date: 2019-07-03

175676-65-0, 2-(Trifluormethoxy)phenylboronic acidRelated Search:

p-Anisaldehyde 4-Trifluoromethylphenylboronic acid 4-(Trifluoromethoxy)benzaldehyde 4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide 4'-(Trifluoromethoxy)acetophenone 4-Methoxybenzoyl chloride 4-(Trifluoromethoxy)chlorobenzene (Trifluoromethoxy)benzene Phenylboronic acid 2,3,4-Trimethoxybenzaldehyde 2-(Trifluoromethoxy)aniline Anisole Ethyl 2-(Chlorosulfonyl)acetate Folic acid p-Trifluoromethoxy phenol (4-METHOXYPHENYL)-BORANE 4-(Trifluoromethoxy)aniline

AKOS BRN-0449

2-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID

2-(TRIFLUORMETHOXY)PHENYLBORONIC ACID

2-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID

RARECHEM AH PB 0077

O-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID

2-(Trifluoromethoxy)Phenylboro

2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)

2-(Trifluoromethoxy)benzeneboronic acid ,98%

2-(Trifluoromethoxy)phenylboronic

2-(TrifluoroMethxoy)phenylboronic acid

B-[2-(Trifluoromethoxy)phenyl]boronic acid

TrifluoroMethoxy)phenylboronic ac

Boronic acid, B-[2-(trifluoromethoxy)phenyl]-

2-(Trifluormethoxy)phenylboronicaci

2-Trifluoromethoxyphenylboronic acid - [T5420]

175676-65-0

175676-0

96451-33-9

F3COC6H4BOH2

C7H9O3B

New Products for Chemical Synthesis May/June 2007

Potassium Trifluoroborate

Boronate Ester

Substituted Boronic Acids

Boronic Acid

Aryl

Organoborons

B (Classes of Boron Compounds)

Boronic Acids

Boronic Acids and Derivatives

blocks

BoronicAcids

FluoroCompounds

Boronic Acid series