STATIL

Product Name: STATIL
CAS No.: 72702-95-5
Chemical Name: STATIL
Synonyms: STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil;3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL);2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
CBNumber: CB6193847
Molecular Formula: C17H12BrFN2O3
Formula Weight: 391.19
MOL File: 72702-95-5.mol

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STATIL Property

Melting point:: 184-186℃ (DEC.)
Density: 1.60
storage temp.: Store at RT
solubility: DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form: A crystalline solid
color: White to off-white

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 50mg
Price: $139
Updated: 2024/03/01

TRC

Product number: S684550
Product name: Statil
Packaging: 25mg
Price: $95
Updated: 2021/12/16

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STATIL Chemical Properties,Usage,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with K_i values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F_2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

STATIL Preparation Products And Raw materials

Raw materials

Preparation Products

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STATIL Suppliers

China 68 Europe 2 Germany 2 India 1 United Kingdom 2 United States 11 Global 86

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

3B Scientific Corporation

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Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Santa Cruz Biotechnology, Inc.

Tel: --
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Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

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View Lastest Price from STATIL manufacturers

Career Henan Chemical Co

Product: STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; 72702-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

72702-95-5, STATILRelated Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE (2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785 4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE

STATIL

[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID

Ponalrestat

3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid

ICI-128436

ICI-plc

MK-538

2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

Ponalrestat Statil

Ponalrestat (MK-538

ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1

72702-95-5

C17H12BrFN2O3

Inhibitors