Oxazole-4-carbaldehyde

Uses

Product Name: Oxazole-4-carbaldehyde
CAS No.: 118994-84-6
Chemical Name: Oxazole-4-carbaldehyde
Synonyms: 4-FORMYLOXAZOLE;4-Formyl-1,3-oxazole;oxazol-4-carbaldehyde;OXAZOLE-4-CARBALDEHYDE;4-OXAZOLECARBOXALDEHYDE;Oxazole-4-carboxaldehyde;4-Oxazolecarboxaldehyde>1,3-oxazole-4-carbaldehyde;4-Oxazolecarboxaldehyde 97%;1,3-Oxazole-4-carboxaldehyde
CBNumber: CB6194334
Molecular Formula: C4H3NO2
Formula Weight: 97.07
MOL File: 118994-84-6.mol

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Oxazole-4-carbaldehyde Property

Melting point:: 57-61 °C
Boiling point:: 184.7±13.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -1.49±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C4H3NO2/c6-1-4-2-7-3-5-4/h1-3H
InChIKey: JBWIIXBEPINWPB-UHFFFAOYSA-N
SMILES: O1C=C(C=O)N=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-43
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 697915
Product name: 4-Oxazolecarboxaldehyde
Purity: 97%
Packaging: 250mg
Price: $205
Updated: 2025/07/31

Sigma-Aldrich

Product number: 697915
Product name: 4-Oxazolecarboxaldehyde
Purity: 97%
Packaging: 1g
Price: $308
Updated: 2025/07/31

TCI Chemical

Product number: O0453
Product name: 4-Oxazolecarboxaldehyde
Purity: >98.0%(GC)
Packaging: 200mg
Price: $91
Updated: 2021/12/16

TCI Chemical

Product number: O0453
Product name: 4-Oxazolecarboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $312
Updated: 2021/12/16

TRC

Product number: O990188
Product name: Oxazole-4-carbaldehyde
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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Oxazole-4-carbaldehyde Chemical Properties,Usage,Production

Uses

Oxazole-4-carboxaldehyde is mainly used in laboratory organic synthesis and in chemical and pharmaceutical research and development processes.

Synthesis

155742-48-6

118994-84-6

The general procedure for the synthesis of oxazole-4-carbaldehyde from 4-oxazolemethanol was as follows: a solution of anhydrous dichloromethane (200 mL) with dimethylsulfoxide (DMSO, 19.3 mL, 272 mmol) was added slowly and dropwise to a solution of anhydrous dichloromethane (200 mL) with oxalyl chloride (17.3 mL, 204 mmol) at -63 °C. The reaction mixture was stirred at -63 °C for 15 min before adding an anhydrous dichloromethane (200 mL) solution of 4-oxazole methanol (13.5 g, 204 mmol) with a controlled dropwise addition time of 15 min. Stirring was continued at -63 °C for 60 min, followed by the addition of triethylamine (Et3N, 53.1 mL, 381 mmol). The reaction mixture was gradually warmed up to room temperature. Upon completion of the reaction, the mixture was combined with 10% aqueous citric acid solution and extracted with dichloromethane (4 times) and ethyl acetate (2 times). The organic phases were combined, washed with a small amount of saturated aqueous sodium bicarbonate solution and extracted again with dichloromethane (3 times) and ethyl acetate (3 times). All organic phases were combined, dried with magnesium sulfate (MgSO4), filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: ether/petroleum ether, ratio tapered from 1:1 to 2:1, to 4:1 and finally 1:0) to give oxazole-4-carbaldehyde (11.9 g, 86% yield). Thin layer chromatography (TLC) showed an Rf value of 0.65 (Expander: methanol/dichloromethane, 1:9).

References

[1] Patent: WO2006/21402, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: WO2005/105802, 2005, A1. Location in patent: Page/Page column 109-110

Oxazole-4-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxazole-4-carbaldehyde Suppliers

Americas 1 China 121 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 18 Global 147

HBCChem, Inc.

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View Lastest Price from Oxazole-4-carbaldehyde manufacturers

Honest Joy Holdings Limited

Product: 4-Oxazolecarboxaldehyde 118994-84-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 100 tons
Release date: 2022-01-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: Oxazole-4-carbaldehyde 118994-84-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Oxazole-4-carbaldehyde 118994-84-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-21

118994-84-6, Oxazole-4-carbaldehydeRelated Search:

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4-FORMYLOXAZOLE

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118994-84-6

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