SIGUAZODAN

Product Name: SIGUAZODAN
CAS No.: 115344-47-3
Chemical Name: SIGUAZODAN
Synonyms: SKF 94836;SIGUAZODAN;SK AND F-94836;Siguazodan (SKF 94836);SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor;N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine;N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE;Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-;4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one;Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
CBNumber: CB6229034
Molecular Formula: C14H16N6O
Formula Weight: 284.32
MOL File: 115344-47-3.mol

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SIGUAZODAN Property

Melting point:: 268-268.9 °C(lit.)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >5 mg/mL, freely soluble
form: solid
pka: 13.71±0.60(Predicted)
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris

Product number: 1148
Product name: Siguazodan
Purity: ≥99%(HPLC)
Packaging: 10
Price: $122
Updated: 2021/12/16

Tocris

Product number: 1148
Product name: Siguazodan
Purity: ≥99%(HPLC)
Packaging: 50
Price: $510
Updated: 2021/12/16

TRC

Product number: S497058
Product name: Siguazodan
Packaging: 5mg
Price: $330
Updated: 2021/12/16

Usbiological

Product number: 256668
Product name: Siguazodan
Packaging: 10mg
Price: $423
Updated: 2021/12/16

ChemScene

Product number: CS-0014736
Product name: Siguazodan
Purity: >99.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

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SIGUAZODAN Chemical Properties,Usage,Production

Uses

Siguazodan is a selective phosphodiesterase PDE III inhibitor and a potent inotropic agent.

Definition

ChEBI: 1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine is a pyridazinone.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE3 (IC 50 = 117 nM).

SIGUAZODAN Preparation Products And Raw materials

Raw materials

Preparation Products

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SIGUAZODAN Suppliers

China 38 Germany 2 Switzerland 1 United Kingdom 4 United States 11 USA 1 Global 57

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115344-47-3, SIGUAZODANRelated Search:

ZARDAVERINE RO 20-1724 AG 1295 S- (+)-Rolipram ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE SIGUAZODAN (R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Dicyandiamide N-CYANO-N',N'-DIMETHYLGUANIDINE

SIGUAZODAN

SK AND F-94836

SKF 94836

N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE

N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine

Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine

Siguazodan (SKF 94836)

[4R,(-)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one

[4S,(+)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one

4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one

Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-

SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor

115344-47-3

C14H16N6O

Cell Biology

Cell Signaling and Neuroscience

BioChemical

G Proteins and Cyclic Nucleotides

Phosphodiesterase Inhibitors

Cyclic Nucleotide Metabolism

Cyclic Nucleotide related