Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride
- Product Name
- Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride
- CAS No.
- 27083-27-8
- Chemical Name
- Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride
- Synonyms
- enebicyanog;PolyhexaMethylene biguanidine hydrochloride (PHMB);POLY(BIGUANIDE-1,5-DIYLHEXAMETHYLENEHYDROCHLORIDE);1,6-hexanediamine,polymerwithn,n’’’-1,6-hexanediylbis{n’-cyanoguanidine},hydrochloride;2-[6-[[Amino-(cyanoamino)methylidene]amino]hexyl]-1-cyano-guanidine hexane-1,6-diamine polymer hydrochloride;y(hexamethyL;uanide-hexamethyL;enediamine) HydrochL;enebicyanoguanide-hexamethyL;PolyhexaMethylene biguanide (PHMB)
- CBNumber
- CB6229135
- Molecular Formula
- C16H34N10
- Formula Weight
- 366.52
- MOL File
- 27083-27-8.mol
Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride Property
- solubility
- soluble in DMSO, Methanol, Water
- form
- Solid
- color
- White
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C10H18N8.C6H16N2/c11-7-17-9(13)15-5-3-1-2-4-6-16-10(14)18-8-12;7-5-3-1-2-4-6-8/h1-6H2,(H3,13,15,17)(H3,14,16,18);1-8H2
- InChIKey
- ZOLRUJSKYUSXCW-UHFFFAOYSA-N
- SMILES
- C(CCN)CCCN.N(C(=N)NC#N)CCCCCCNC(=N)NC#N
- CAS DataBase Reference
- 27083-27-8(CAS DataBase Reference)
- EPA Substance Registry System
- 1,6-Hexanediamine, polymer with N,N'''-1,6-hexanediylbis[N'-cyanoguanidine], hydrochloride (27083-27-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P284Wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P689200
- Product name
- Poly(hexamethylenebicyanoguanide-hexamethylenediamine)Hydrochloride(TechnicalGrade)
- Packaging
- 100g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 72063
- Product name
- Poly(hexamethylenebicyanoguanide-hexamethylenediamine)HCl(TechnicalGrade)
- Packaging
- 25g
- Price
- $650
- Updated
- 2021/12/16
Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride Chemical Properties,Usage,Production
Uses
Poly(hexamethylenebicyanoguanide-hexamethylenediamine) Hydrochloride is used in the stabilization of fabric linings in shoes. Biguanide solution used in cleaning contact lenses.
Application
Polyhexamethylene biguanide hydrochloride has a broad-spectrum antibacterial, Gram-positive bacteria, Gram-negative bacteria, fungi and yeast, etc. have a killing effect. It is commonly used in women's lotion, sanitary wipes sterilization and anti-mold agent, fruit and vegetable, aquatic products disinfectant, sewage treatment flocculation disinfectant, etc.
Application
In addition to its use as a biocide, PHMB is a preservative in cosmetics and is considered safe when used at concentrations of ≤ 0.1% (approximately 1 mg/mL; 3.5 mM), according to the Scientific Committee on Consumer Safety. Moreover, PHMB can be found in medicinal (e.g., perioperative cleansing products, wound care dressings), industrial (e.g., swimming pool disinfectants, leather preservatives, agricultural and food handling cleaners), and consumer products (e.g., wet wipes, contact lens cleaning solution). It is used as an ophthalmic agent in the 0.02–0.08% concentration range. In other applications, such as swimming pool disinfection and shampoos, PHMB may be present at concentrations ranging from 0.03% to 4%. Therefore, exposure levels are generally expected to remain below 0.02%.
Mechanism of action
Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride (PHMB), a synthetic polymer, is a cationic biocide used as a disinfectant because of its broad-spectrum antibacterial activity. PHMB interacts with the negatively charged head group of phospholipids, resulting in increased permeability, fluidity, and loss of integrity, ultimately causing mortality of microorganisms. PHMB can exhibit a biocidal effect by penetrating the cytoplasm and binding to DNA and RNA; hence, it significantly impacts cell biological systems such as cell growth and division, as well as nucleic acid replication and repair. Interestingly, in mammalian cells, PHMB is trapped within endosomes and excluded from the nucleus, suggesting that PHMB selectively binds and condenses bacterial chromosomes to exhibit antibacterial activity.
Side effects
While most literature reports minimal skin irritations and few side effects, it is notable that a hospital disinfectant containing 0.2% PHMB has been reported to trigger severe anaphylaxis. Furthermore, some patients with keratitis treated with 0.2% PHMB experienced ocular toxicity, including conjunctival inflammation and epithelial defects. Stability studies on ophthalmic formulations of PHMB revealed that PHMB was physicochemically stable throughout the study for up to 2 months.
Metabolism
It is unclear how Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride (PHMB) is metabolized in vivo; however, most rodent studies involving exposure to PHMB through dietary and drinking water intake in the range of 20–2000 ppm or 20–4000 mg/kg suggest that the primary excretion routes are feces and urine. In rats exposed to PHMB through their diet, the substances 3,3-dicyano-1,1-hexamethylene-diguanidine and 1-(6-aminohexyl)? 3-cyanoguanidine were detected in the urine.
Toxicity evaluation
Cytotoxicity to Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride (PHMB) has been shown in several human-derived cell lines, such as human dermal keratinocytes, dermal fibroblasts and osteoblasts, and lung adenocarcinoma cells. Toxicological studies have revealed that PHMB induces a severe inflammatory response and can trigger cytotoxicity through endoplasmic reticulum stress. The liver and kidneys are the target organs for PHMB, but they also affect the lungs. PHMB can alter the cell membrane structure and permeability, which can have significant consequences when interacting with neurons within the nervous system.
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View Lastest Price from Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride manufacturers
- Product
- PHMB 27083-27-8
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 20%;99%
- Supply Ability
- 10 TONS
- Release date
- 2021-06-21
- Product
- Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride 27083-27-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-10
- Product
- Polyhexamethylene biguanide 27083-27-8
- Price
- US $5.90-3.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-07-01