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PROCYCLIDINE HYDROCHLORIDE

Product Name
PROCYCLIDINE HYDROCHLORIDE
CAS No.
1508-76-5
Chemical Name
PROCYCLIDINE HYDROCHLORIDE
Synonyms
kemadrin;PROCYCLIDINE HCL;D00782;Osnervan;Arpicolin;Kemadrin (tn);kemadrinhydrochloride;PROCYCLIDINE HYDROCHLORIDE;(±)-Procyclidine hydrochlorid;Procyclidine hydrochloride (usp)
CBNumber
CB6229812
Molecular Formula
C19H30ClNO
Formula Weight
323.9
MOL File
1508-76-5.mol
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PROCYCLIDINE HYDROCHLORIDE Property

Melting point:
159-164 °C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
UY1926000
HS Code 
2933997500
Toxicity
mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P3794
Product name
Procyclidine hydrochloride
Packaging
1g
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
1567004
Product name
Procyclidine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$174.4
Updated
2024/03/01
Sigma-Aldrich
Product number
P3794
Product name
Procyclidine hydrochloride
Packaging
5g
Price
$629
Updated
2024/03/01
Usbiological
Product number
019991
Product name
Procyclidine Hydrochloride
Packaging
10mg
Price
$460
Updated
2021/12/16
TRC
Product number
P755840
Product name
Procyclidine hydrochloride
Packaging
5g
Price
$480
Updated
2021/12/16
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PROCYCLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.

brand name

Kemadrin (Monarch).

General Description

Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.

Biochem/physiol Actions

Procyclidine is a synthetic anti-cholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against Parkinson′s disease and schizophrenia. Procyclidine acts as a muscarinic receptor antagonist. It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

Clinical Use


Control of extrapyramidal symptoms
Acute dystonias

Metabolism

When given orally about one fifth of the dose is known to be metabolised in the liver, principally by cytochrome P450 and then conjugated with glucuronic acid. Metabolites have been found in the urine.

PROCYCLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROCYCLIDINE HYDROCHLORIDE Suppliers

Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Whyte Chemicals
Tel
--
Fax
--
Email
sales@whytechemicals.co.uk
Country
United Kingdom
ProdList
3748
Advantage
50
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
Eurolabs Limited
Tel
--
Fax
--
Country
United Kingdom
ProdList
6309
Advantage
46

1508-76-5, PROCYCLIDINE HYDROCHLORIDERelated Search:


  • a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride
  • alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanomonohydrochloride
  • kemadrin
  • kemadrinhydrochloride
  • PROCYCLIDINE HCL
  • PROCYCLIDINE HYDROCHLORIDE
  • ALPHA-CYCLOHEXYL-ALPHA-PHENYL-1-PYRROLIDINEPROPANOL HYDROCHLORIDE
  • α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol
  • D00782
  • Kemadrin (tn)
  • Procyclidine hydrochloride (usp)
  • Procyclidine Hydrochloride (200 mg)
  • Arpicolin
  • Osnervan
  • α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol Hydrochloride
  • α-Cyclohexyl-α-phenyl-1-pyrrolidinopropanol
  • 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, hydrochloride
  • (±)-Procyclidine hydrochlorid
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  • Soman,Tricyclamol,inhibit,mAChR,Procyclidine,Parkinson's disease,Ionotropic glutamate receptors,anticholinergic,Inhibitor,(±)-Procyclidine,Muscarinic acetylcholine receptor,NMDA,Procyclidine hydrochloride,muscarinic receptor,epilepsy,iGluR
  • -(1,2-Propanediyl)bis[1-(4-morpholinylmethyl)-2,6-piperazinedione
  • Procyclidine hydrochloride in methanol
  • 1508-76-5
  • C19H29NOHCl
  • KEMADRIN
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