5-(BOC-AMINO)-1-PENTANOL
- Product Name
- 5-(BOC-AMINO)-1-PENTANOL
- CAS No.
- 75178-90-4
- Chemical Name
- 5-(BOC-AMINO)-1-PENTANOL
- Synonyms
- DK889;5-Boc-Ava-ol;BOC-APE(5)-OL;Boc-NH-Pen-OH;BOC-NH-(CH2)5-OH;BOC-5-AMINOPENTANOL;N-BOC-5-AMINOPENTANOL;5-(Boc-amino)-pentanol;5-(Boc-amino)pentan-1-ol;5-(BOC-AMINO)-1-PENTANOL
- CBNumber
- CB6233161
- Molecular Formula
- C10H21NO3
- Formula Weight
- 203.28
- MOL File
- 75178-90-4.mol
5-(BOC-AMINO)-1-PENTANOL Property
- Boiling point:
- 318.4±25.0 °C(Predicted)
- Density
- 1.00 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.45
- Flash point:
- >109°C
- storage temp.
- 2-8°C
- solubility
- Chloroform, Dichloromethane, Ethyl Acetate, Methanol
- form
- Oil
- pka
- 12.88±0.46(Predicted)
- color
- Pale Yellow
- Water Solubility
- Difficult to mix in water.
- Sensitive
- Moisture Sensitive
- BRN
- 3603659
- CAS DataBase Reference
- 75178-90-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- B2869
- Product name
- 5-(tert-Butoxycarbonylamino)-1-pentanol
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- B2869
- Product name
- 5-(tert-Butoxycarbonylamino)-1-pentanol
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $501
- Updated
- 2025/07/31
- Product number
- B621025
- Product name
- 5-(t-Boc-amino)-1-pentanol
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- B621025
- Product name
- 5-(t-Boc-amino)-1-pentanol
- Packaging
- 10g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 12962
- Product name
- 5-(Boc-amino)-1-pentanol
- Purity
- ≥ 97% (Assay)
- Packaging
- 1ML
- Price
- $30
- Updated
- 2021/12/16
5-(BOC-AMINO)-1-PENTANOL Chemical Properties,Usage,Production
Description
5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
Pale Yellow Oil
Uses
Linker (anthraquinone-oligopeptide)
Uses
5-(Boc-amino)-1-pentanol may also be used as non-limiting linkers.
Synthesis Reference(s)
Synthetic Communications, 20, p. 773, 1990 DOI: 10.1080/00397919008052321
reaction suitability
reagent type: cross-linking reagent
Synthesis
2508-29-4
24424-99-5
75178-90-4
The general procedure for the synthesis of 5-(N-tert-butoxycarbonylamino)-1-pentanol from 5-amino-1-pentanol and di-tert-butyl dicarbonate is as follows: 1. 5-amino-1-pentanol (15.0 g, 145.4 mmol) was dissolved in water (140 mL) and saturated aqueous NaHCO3 solution (1.4 mL) in a 1.0 L single-necked round-bottomed flask. 2. To the above solution was slowly added a solution of di-tert-butyl dicarbonate (33.3 g, 152.7 mmol) in THF (280 mL). 3. The reaction mixture was stirred overnight at room temperature, keeping the flask open to the atmosphere. 4. Upon completion of the reaction, the reaction mixture was diluted with saturated aqueous NaHCO3 solution (90 mL) and extracted with EtOAc (400 mL). 5. The organic layer was separated, dried over anhydrous Na2SO4, filtered and the solvent evaporated to give 28.9 g (98% yield) of 5-(N-tert-butoxycarbonylamino)-1-pentanol as a clear colorless oil. 6. The purity of the product was confirmed by NMR analysis and no further purification was carried out. Note: 5-(N-Boc-amino)-1-pentanol is also available from TCI America (Portland, OR).
References
[1] Synthesis, 1990, p. 366 - 368
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 7892 - 7901
[3] Tetrahedron Letters, 1992, vol. 33, # 20, p. 2833 - 2836
[4] Carbohydrate Research, 1999, vol. 322, # 3-4, p. 201 - 208
[5] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1376 - 1392
5-(BOC-AMINO)-1-PENTANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(BOC-AMINO)-1-PENTANOL manufacturers
- Product
- 5-(BOC-AMINO)-1-PENTANOL 75178-90-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09