5-(BOC-AMINO)-1-PENTANOL

Product Name: 5-(BOC-AMINO)-1-PENTANOL
CAS No.: 75178-90-4
Chemical Name: 5-(BOC-AMINO)-1-PENTANOL
Synonyms: DK889;5-Boc-Ava-ol;BOC-APE(5)-OL;Boc-NH-Pen-OH;BOC-NH-(CH2)5-OH;BOC-5-AMINOPENTANOL;N-BOC-5-AMINOPENTANOL;5-(Boc-amino)-pentanol;5-(Boc-amino)pentan-1-ol;5-(BOC-AMINO)-1-PENTANOL
CBNumber: CB6233161
Molecular Formula: C10H21NO3
Formula Weight: 203.28
MOL File: 75178-90-4.mol

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5-(BOC-AMINO)-1-PENTANOL Property

Boiling point:: 318.4±25.0 °C(Predicted)
Density: 1.00 g/mL at 20 °C(lit.)
refractive index: n20/D 1.45
Flash point:: >109°C
storage temp.: 2-8°C
solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form: Oil
pka: 12.88±0.46(Predicted)
color: Pale Yellow
Water Solubility: Difficult to mix in water.
Sensitive: Moisture Sensitive
BRN: 3603659
CAS DataBase Reference: 75178-90-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 23-24/25
WGK Germany: 3
F: 10-21
Hazard Note: Irritant
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2869
Product name: 5-(tert-Butoxycarbonylamino)-1-pentanol
Purity: >97.0%(GC)
Packaging: 5g
Price: $150
Updated: 2025/07/31

TCI Chemical

Product number: B2869
Product name: 5-(tert-Butoxycarbonylamino)-1-pentanol
Purity: >97.0%(GC)
Packaging: 25g
Price: $501
Updated: 2025/07/31

TRC

Product number: B621025
Product name: 5-(t-Boc-amino)-1-pentanol
Packaging: 10g
Price: $210
Updated: 2021/12/16

TRC

Product number: B621025
Product name: 5-(t-Boc-amino)-1-pentanol
Packaging: 1g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB10493
Product name: 5-(BOC-amino)-1-pentanol
Packaging: 1g
Price: $80
Updated: 2021/12/16

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5-(BOC-AMINO)-1-PENTANOL Chemical Properties,Usage,Production

Description

5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Pale Yellow Oil

Uses

Linker (anthraquinone-oligopeptide)

Uses

5-(Boc-amino)-1-pentanol may also be used as non-limiting linkers.

Synthesis Reference(s)

Synthetic Communications, 20, p. 773, 1990 DOI: 10.1080/00397919008052321

reaction suitability

reagent type: cross-linking reagent

Synthesis

2508-29-4

24424-99-5

75178-90-4

The general procedure for the synthesis of 5-(N-tert-butoxycarbonylamino)-1-pentanol from 5-amino-1-pentanol and di-tert-butyl dicarbonate is as follows: 1. 5-amino-1-pentanol (15.0 g, 145.4 mmol) was dissolved in water (140 mL) and saturated aqueous NaHCO3 solution (1.4 mL) in a 1.0 L single-necked round-bottomed flask. 2. To the above solution was slowly added a solution of di-tert-butyl dicarbonate (33.3 g, 152.7 mmol) in THF (280 mL). 3. The reaction mixture was stirred overnight at room temperature, keeping the flask open to the atmosphere. 4. Upon completion of the reaction, the reaction mixture was diluted with saturated aqueous NaHCO3 solution (90 mL) and extracted with EtOAc (400 mL). 5. The organic layer was separated, dried over anhydrous Na2SO4, filtered and the solvent evaporated to give 28.9 g (98% yield) of 5-(N-tert-butoxycarbonylamino)-1-pentanol as a clear colorless oil. 6. The purity of the product was confirmed by NMR analysis and no further purification was carried out. Note: 5-(N-Boc-amino)-1-pentanol is also available from TCI America (Portland, OR).

References

[1] Synthesis, 1990, p. 366 - 368
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 7892 - 7901
[3] Tetrahedron Letters, 1992, vol. 33, # 20, p. 2833 - 2836
[4] Carbohydrate Research, 1999, vol. 322, # 3-4, p. 201 - 208
[5] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1376 - 1392

5-(BOC-AMINO)-1-PENTANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(BOC-AMINO)-1-PENTANOL Suppliers

Americas 1 Canada 1 China 103 Europe 3 France 1 Germany 3 India 10 Japan 3 Switzerland 1 United Kingdom 6 United States 13 Global 145

Accela ChemBio Inc.

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View Lastest Price from 5-(BOC-AMINO)-1-PENTANOL manufacturers

Career Henan Chemical Co

Product: 5-(BOC-AMINO)-1-PENTANOL 75178-90-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

75178-90-4, 5-(BOC-AMINO)-1-PENTANOLRelated Search:

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N-TU-BUTOXYCARBONYL-5-AMINO-1-PENTANOL

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1-(tert-Butoxycarbonylamino)-5-pentanol

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N-(tert-Butoxycarbonyl)-5-aminopentanol

N-(5-Hydroxypentyl)carbaMic Acid 1,1-DiMethylethyl Ester

N-Boc-5-aminopentanol tert-Butyl N-(5-Hydroxypentyl)carbamate N-(5-Hydroxypentyl)carbamic Acid tert-Butyl Ester

tert-Butyl (5-hydroxypent-1-yl)carbamate, 5-Hydroxypentylamine, N-BOC protected

5-Aminopentan-1-ol,N-BOCprotected95%

5-(<i>tert</i>-Butoxycarbonylamino)-1-pentanol

N-(tert-butyloxycarbonyl)-5-aminopentanol

tert-Butyl (5-hydroxypentyl)

5-(Boc-amino)-1-pentanol≥ 97% (HPLC)

5-Boc-Ava-ol

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5-AMINOPENTAN-1-OL, N-BOC PROTECTED

5-(BOC-AMINO)-1-PENTANOL

5-(TERT-BUTOXYCARBONYLAMINO)-1-PENTANOL

5-(T-BOC-AMINO)-1-PENTANOL

BOC-NH-(CH2)5-OH

BOC-5-AMINOPENTANOL

BOC-APE(5)-OL

5-(Boc-Amino)-1-Pentanoll

5-Aminopentan-1-ol, N-BOC protected 95%

N-BOC-5-AMINO-1-PENTANOL

Boc-NH-Pen-OH

N-t-Butyloxycarbonyl-5-hydroxy-pentylamine

5-(tert-Butoxycarbonylamino)-1-pentanol &gt

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tert-butyl 3-allyl-3-hydroxyazetidine-64-carboxylate

DK889

75178-90-4

CH33CO2CNHCH25OH

CH33COCONHCH25OH

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