Cyclobenzaprine hydrochloride

ChemicalBook > CAS DataBase List > Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride

Product Name: Cyclobenzaprine hydrochloride
CAS No.: 6202-23-9
Chemical Name: Cyclobenzaprine hydrochloride
Synonyms: CYCLOBENZAPRINE HCL;flexeril;Flexiba;Lisseril;flexiban;Cyclobezaprine HCl;MK130 hydrochloride;Nortriptyline EP Impurity E;Amitriptyline EP Impurity B;Cyclobenzaprine HCl (MK130)
CBNumber: CB6238272
Molecular Formula: C20H22ClN
Formula Weight: 311.85
MOL File: 6202-23-9.mol

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Cyclobenzaprine hydrochloride Property

Melting point:: 216-2180C
Flash point:: 9℃
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Completely soluble in water
solubility: ≥15.59 mg/mL in DMSO; ≥5.32 mg/mL in EtOH; ≥54.3 mg/mL in H2O
form: Solid
color: White to Almost white
λmax: 290nm(lit.)
Merck: 14,2713
InChIKey: VXEAYBOGHINOKW-UHFFFAOYSA-N
CAS DataBase Reference: 6202-23-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 36-45-36/37-16-7
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HP0875000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29214990
Toxicity: LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C4542
Product name: Cyclobenzaprine hydrochloride
Packaging: 1g
Price: $165
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2797
Product name: Cyclobenzaprine Hydrochloride
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 400MG
Price: $280
Updated: 2024/03/01

Sigma-Aldrich

Product number: C-060
Product name: Cyclobenzaprine hydrochloride solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $38.1
Updated: 2024/03/01

TCI Chemical

Product number: C3157
Product name: Cyclobenzaprine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: C3157
Product name: Cyclobenzaprine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $104
Updated: 2024/03/01

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Cyclobenzaprine hydrochloride Chemical Properties,Usage,Production

Description

Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (K_is = 25, 60, and 6 nM for M₁, M₂, and M₃, respectively), serotonin 5-HT₂ receptors (K_is = 56 and 330 nM for 5-HT_2C and 5-HT_2B, respectively), and histamine H₁ receptor (IC₅₀ = 20 nM).

Chemical Properties

Crystalline Solid

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

Uses

Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.

Uses

Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).

Definition

ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

General Description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of?noradrenaline. It is used to treat neck,?back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

References

[1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
[2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
[3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.

Cyclobenzaprine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclobenzaprine hydrochloride manufacturers

Guangzhou Tengyue Chemical Co., Ltd.

Product: Cyclobenzaprine hydrochloride 6202-23-9
Price: US $90.00/kg
Min. Order: 1kg
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2024-03-22

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Product: Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl 6202-23-9
Price: US $10.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 1000kg
Release date: 2021-06-29

Career Henan Chemical Co

Product: Cyclobenzaprine hydrochloride 6202-23-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-08

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6202-23-9

6202-32-9

C20H21NClH

C20H22ClN

C20H21NHCl

Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.

Intermediates & Fine Chemicals