2-Aminobenzimidazole Property

Melting point:

226-230 °C (lit.)

Boiling point:

235.67°C (rough estimate)

Density 

1.1873 (rough estimate)

refractive index 

1.5341 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

<1g/l slightly soluble

pka

11.41±0.10(Predicted)

form 

Crystalline Powder, Crystals or Flakes

color 

Yellow to beige or light brown

Water Solubility 

Soluble in water (Slightly).

BRN 

116525

InChIKey

JWYUFVNJZUSCSM-UHFFFAOYSA-N

CAS DataBase Reference

934-32-7(CAS DataBase Reference)

NIST Chemistry Reference

2-Aminobenzimidazole(934-32-7)

EPA Substance Registry System

2-Aminobenzimidazole (934-32-7)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-43

Safety Statements 

26-36/37/39-22

WGK Germany 

3

RTECS 

DD5775000

TSCA 

Yes

HS Code 

29339990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

2-Aminobenzimidazole Chemical Properties,Usage,Production

Chemical Properties

Light yellow to cream or beige powder or flakes. N,N'-o-Phenyleneguanidine [934-32-7], 2-aminobenzimidazole, C7H7N3, Mr 133.15, mp 231 – 232 ℃(decomp.), obtained by cyclization of o-phenylenediamine with cyanogen chloride or cyanamide, is the nucleus for a number of compounds of economic interest.

Uses

2-Aminobenzimidazole was used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.

Preparation

Synthesis of 2-aminobenzimidazole: Cyanogen bromide (3.5 g., 0.034 mole) was added in small portions, with shaking, to a suspension of o-phenylenediamine (4.2 g. , 0.34 mole) in water (40 ml), the exothermic reaction mixture was cooled to room temperature and it was stirred for 36hrs. The solution was filtered after standing overnight. Sodium hydroxide (1.4 g., 0.034 mole) in 30 ml of water was then added and the solution was evaporated. The solid thus obtained was filtered and recrystalized from water. Yield 85%, m.p. 228 - 230°C

Definition

ChEBI: 2-aminobenzimidazole is a member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group. It has a role as a marine xenobiotic metabolite.

General Description

Plates (in water); white powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Aminobenzimidazole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-Aminobenzimidazole emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for 2-Aminobenzimidazole are not available; however, 2-Aminobenzimidazole is probably combustible.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic NO,. See also AROUTIC AMINES.